5.7 Hyperalimentation and electrolyte requirements in very preterm infants: a randomised controlled parenteral nutrition study: Abstract 5.7 Table 1

2014 ◽  
Vol 99 (Suppl 1) ◽  
pp. A6.1-A6
Author(s):  
J Green ◽  
P McGowan
Keyword(s):  
Parenteral Nutrition ◽  
Preterm Infants ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Nutrition Study ◽  
Randomised Controlled

scholarly journals Early versus later initiation of parenteral nutrition for very preterm infants: a propensity score-matched observational study

2021 ◽  
pp. fetalneonatal-2021-322383
Author(s):  
Sabita Uthaya ◽  
Nicholas Longford ◽  
Cheryl Battersby ◽  
Kayleigh Oughham ◽  
Julia Lanoue ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Preterm Infants ◽  
Late Onset ◽  
Controlled Trial ◽  
Absolute Difference ◽  
Research Database ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled ◽  
The Impact

ObjectiveTo evaluate the impact of timing of initiation of parenteral nutrition (PN) after birth in very preterm infants.DesignPropensity-matched analysis of data from the UK National Neonatal Research Database.Patients65 033 babies <31 weeks gestation admitted to neonatal units in England and Wales between 2008 and 2019.InterventionsPN initiated in the first 2 days (early) versus after the second postnatal day (late). Babies who died in the first 2 days without receiving PN were analysed as ‘late’.Main outcome measuresThe main outcome measure was morbidity-free survival to discharge. The secondary outcomes were survival to discharge, growth and other core neonatal outcomes.FindingsNo difference was found in the primary outcome (absolute rate difference (ARD) between early and late 0.50%, 95% CI −0.45 to 1.45, p=0.29). The early group had higher rates of survival to discharge (ARD 3.3%, 95% CI 2.7 to 3.8, p<0.001), late-onset sepsis (ARD 0.84%, 95% CI 0.48 to 1.2, p<0.001), bronchopulmonary dysplasia (ARD 1.24%, 95% CI 0.30 to 2.17, p=0.01), treated retinopathy of prematurity (ARD 0.50%, 95% CI 0.17 to 0.84, p<0.001), surgical procedures (ARD 0.80%, 95% CI 0.20 to 1.40, p=0.01) and greater drop in weight z-score between birth and discharge (absolute difference 0.019, 95% CI 0.003 to 0.035, p=0.02). Of 4.9% of babies who died in the first 2 days, 3.4% were in the late group and not exposed to PN.ConclusionsResidual confounding and survival bias cannot be excluded and justify the need for a randomised controlled trial powered to detect differences in important functional outcomes.

Sign in / Sign up

Export Citation Format

Share Document