scholarly journals Unusual case of adult familial Menetrier disease in siblings

2019 ◽  
Vol 12 (10) ◽  
pp. e231175
Author(s):  
Emily Brownson ◽  
Adrian J Stanley ◽  
Prakash Konanahalli ◽  
John P Seenan
Keyword(s):  
Family History ◽  
Iron Deficiency ◽  
Gastric Mucosa ◽  
Iron Deficiency Anaemia ◽  
Unusual Case ◽  
Gastric Epithelium ◽  
Deficiency Anaemia ◽  
History Of ◽  
Mucosal Folds ◽  
Gastric Malignancy

Menetrier disease is a rare disease characterised by hyperplasia of the gastric epithelium and large gastric folds. We present a case of a 58-year-old woman who was referred with iron deficiency anaemia, with a family history of a sibling who had undergone gastrectomy for presumed gastric malignancy. Endoscopy showed prominent gastric mucosal folds and biopsies showed hyperplastic gastric mucosa, with prominent foveolar hyperplasia suggestive of Menetrier disease. Further information about her brother’s diagnosis was sought, and it was found that his pathology after gastrectomy showed diffuse glandular hyperplasia also in keeping with Menetrier disease. Adult familial Menetrier disease has so far been a rarity in the literature—review elicits five previous cases of this presentation in siblings.

scholarly journals The gastric mucosa in anaemia in Punjabis: Part I In iron-deficiency anaemia

Gut ◽  
1966 ◽  
Vol 7 (3) ◽  
pp. 234-238 ◽  
Author(s):  
B. Cowan ◽  
S. Joseph ◽  
V. K. Satija
Keyword(s):  
Iron Deficiency ◽  
Gastric Mucosa ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction in the Jervell and Lange-Nielsen Syndrome

2012 ◽  
Vol 23 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Annika Winbo ◽  
Olof Sandström ◽  
Richard Palmqvist ◽  
Annika Rydberg
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Clinical Symptoms ◽  
Gastrointestinal Symptoms ◽  
Gastrin Level ◽  
P Value ◽  
Faecal Calprotectin ◽  
Deficiency Anaemia ◽  
History Of ◽  
Record Review

AbstractAimWe investigated extra-cardiac clinical symptoms and signs in the rare Jervell and Lange-Nielsen Syndrome, characterised by impairedKCNQ1function, a gene essential for gastric acid secretion.MethodsAll Swedish Jervell and Lange-Nielsen cases with doubleKCNQ1mutations (14 cases) were investigated by medical record review, an interview, and were offered laboratory testing for iron-deficiency anaemia and gastrointestinal markers.ResultsA history of iron-deficiency anaemia in 12 of 14 patients and subjective gastrointestinal symptoms in 13 of 14 patients was revealed. Previous endoscopy in five cases had revealed no case of coeliac or inflammatory bowel disease but three cases of mucosal hyperplasia/dysplasia. Current signs of anaemia or iron substitution were present in 9 of 12 tested cases. Elevated levels of gastrin in seven of nine cases, pepsinogen in six of seven cases, and faecal calprotectin in nine of nine cases were present. A significant correlation between elevated gastrin levels and concurrent iron-deficiency and/or anaemia was revealed (p-value 0.039).ConclusionsA high frequency of extra-cardiac clinical symptoms and previous medical investigations was found. We propose that the Jervell and Lange-Nielsen Syndrome phenotypically includes gastrointestinal symptoms/signs and secondary iron-deficiency anaemia owing to hypochlorhydria on the basis ofKCNQ1mutations. The resultant elevated gastrin level is a potential risk factor for later gastrointestinal cancer. Clinical monitoring with regard to developing anaemia and hypergastrinaemia should be considered in the Jervell and Lange-Nielsen Syndrome.

scholarly journals A case of pigmented fungiform papillae of tongue in a young female with iron deficiency anaemia

2020 ◽  
Vol 8 (3) ◽  
pp. 1145
Author(s):  
Shoiab M. Patto ◽  
Nazish M. Keena ◽  
Beenish M. Keena
Keyword(s):  
Iron Deficiency ◽  
Clinical Diagnosis ◽  
Iron Deficiency Anaemia ◽  
Young Female ◽  
Fungiform Papillae ◽  
Benign Condition ◽  
Deficiency Anaemia ◽  
History Of ◽  
Benign Nature

Fungiform papillae are red/pink, mushroom shaped projections located on the tip and dorsolateral part of tongue. It harbours several taste buds. Pigmented fungiform papillae is a not so common benign condition which involves pigment deposition in fungiform papillae. Authors report a case of 35 years female who presented with history of blackish spots over tongue for past 10 years with no other associated symptom. Patient had conjunctival pallor (moderate) and rest of the examination was normal. Investigations showed iron deficiency anaemia with Hb. of 9.5 mg/dl. A clinical diagnosis of Pigmented Fungiform Papillae (PFP) with associated Iron Deficiency Anaemia (IDA) was made. Patient was explained in detail about the benign nature of disease and was put on oral iron therapy. Follow up after 2 months was advised.

Late-onset ‘sloughing esophagitis’ (esophagitis dissecans superficialis) associated with bullous pemphigoid

2020 ◽  
Vol 13 (7) ◽  
pp. e235135
Author(s):  
Eliana Carolina Morel-Cerda ◽  
Bryan Adrian Priego-Parra ◽  
Peter Grube-Pagola ◽  
Jose Maria Remes-Troche
Keyword(s):  
Weight Loss ◽  
Autoimmune Disease ◽  
Iron Deficiency ◽  
Bullous Pemphigoid ◽  
Iron Deficiency Anaemia ◽  
Late Onset ◽  
Skin Involvement ◽  
Deficiency Anaemia ◽  
History Of ◽  
Progressive Dysphagia

Pemphigus is a rare autoimmune disease that causes blistering of the skin and oral mucosa. In bullous pemphigoid (BP), skin involvement is predominant, whereas oesophageal involvement is rare, compared with other blistering diseases. We present, herein, the case of a 67-year-old man with a history of successfully treated BP that 2 years later developed progressive dysphagia, unintentional weight loss and iron deficiency anaemia. An endoscopy with biopsies was performed, and its findings were consistent with ‘sloughing esophagitis’ (esophagitis dissecans superficialis) associated with BP. Oesophageal involvement was present during the first weeks, making our case unusual due to the isolated oesophageal symptoms that developed 24 months later.

Gastric Mucosa in Iron Deficiency Anaemia

1970 ◽  
Vol 43 (4) ◽  
pp. 228-231 ◽  
Author(s):  
E. Ikkala ◽  
H.J. Salmi ◽  
M. Siurala
Keyword(s):  
Iron Deficiency ◽  
Gastric Mucosa ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia
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