Malignant peripheral nerve sheath tumour of thyroid: a diagnostic dilemma

2020 ◽  
Vol 13 (4) ◽  
pp. e234374
Author(s):  
Muhammad Hassan Danish ◽  
Muhammad Wasif ◽  
Nasir Ud Din ◽  
Muhammad Sohail Awan

Malignant peripheral nerve sheath tumours of thyroid are rare entities that can present a diagnostic dilemma. We present the case of a patient who presented with neck mass with a history of multiple neck surgeries and airway compression. The patient’s previous histopathology was mistaken for Riedel’s thyroiditis in an outside hospital, which delayed appropriate treatment leading to suffering on part of the patient and frustration on part of the physician. We emphasise that rare malignancies should be considered in rapidly growing neck masses that are causing airway compression, and histopathology of such tumours should be reported by expert pathologists.

2021 ◽  
Vol 14 (11) ◽  
pp. e246445
Author(s):  
Orlando De Jesus ◽  
José G Sánchez Jiménez ◽  
George Santiago Quiñones ◽  
Román Vélez

Stereotactic radiosurgery (SRS) poses a minimal but important risk for tumour transformation, typically occurring 8–10 years after the treatment. Malignant peripheral nerve sheath tumour (MPNST) is the most common tumour arising from a vestibular schwannoma treated with SRS, with only 14 cases previously reported. We present the fifteenth case and describe its evolution and clinical course. A 56-year-old man without a history of neurofibromatosis was diagnosed 9 years prior with a vestibular schwannoma. SRS to the residual tumour was given 3 months later. During the current hospitalisation, he was reoperated where histology confirmed a MPNST. All 15 MPNST cases were analysed, showing a 77% female predominance presenting a malignant transformation at a mean age of 51. The diagnosis was made at a mean time of 74 months after SRS. The mean survival time after diagnosis was 16 months. MPNST arising from benign vestibular schwannoma after SRS treatment is an uncommon but devastating complication.


2013 ◽  
Vol 2013 (may23 1) ◽  
pp. bcr2012008435-bcr2012008435 ◽  
Author(s):  
K. Alam ◽  
A. Jain ◽  
A. Misra ◽  
A. H. khan

1999 ◽  
Vol 113 (10) ◽  
pp. 942-944 ◽  
Author(s):  
T. P. Ho ◽  
P. R. Samuel ◽  
J-P. Jeannon ◽  
J. McElroy

AbstractA 50-year-old man presented with a left-sided neck mass. Clinical examination revealed a large fluctuant 7 cm × 7 cm mass in the left posterior triangle. Magnetic resonance imaging (MRI) revealed an encapsulated soft tissue lesion. He underwent exploration of the neck and a 14 cm by 8 cm mass enfolding the accessory nerve was identified and completely excised. Histological examination of the surgical specimen showed features in keeping with a malignant peripheral nerve sheath tumour (MPNST). We present the clinical and pathological features, of this condition.


2017 ◽  
Vol 3 (1) ◽  
pp. 205511691771039 ◽  
Author(s):  
Ariadna Ribas ◽  
Rachel Miller ◽  
Roberta Rasotto

Case summary A 5-year-old female spayed Chinchilla cat presented with a 4 week history of weight loss and inappetence. A thorough clinical investigation confirmed the presence of a distal jejunal mass. Histopathological and immunohistochemical analysis was consistent with a small intestinal peripheral nerve sheath tumour. Relevance and novel information To the best of our knowledge, this is the first reported case of a small intestinal peripheral nerve sheath tumour in a cat. This case report demonstrates the use of immunohistochemistry in differentiating this entity from other mesenchymal neoplasms. The veterinary literature available in this field is very limited and this report adds a new differential diagnosis to feline patients presenting with an intestinal mass.


2018 ◽  
pp. bcr-2018-224481
Author(s):  
Ryoma Endo ◽  
Tomoko Tomioka ◽  
Ken Okada ◽  
Kanichi Inoue

2006 ◽  
Vol 42 (5) ◽  
pp. 210-212 ◽  
Author(s):  
Anacélia Mendes Fernandes ◽  
Aline Cristina Batista Rodrigues Johann ◽  
João Batista da Silveira-Júnior ◽  
Maria Cássia Ferreira de Aguiar ◽  
Maria Auxiliadora Vieira do Carmo ◽  
...  

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