Eye: the door to undiagnosed chronic myeloid leukaemia

Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm that can present in varied ways from incidental finding on haemogram to symptomatic presentation such as splenomegaly. We report an interesting case of a 22-year-old man who presented with loss of vision in right eye for 1 month. There were no pre-existing ocular or systemic diseases. On detailed ocular examination, a diagnosis of right eye rubeosis iridis, hyphaema, cataract and vitreous haemorrhage with left eye suspected leukaemic retinopathy was made. Routine haemogram revealed high leucocytosis. Systemic evaluation with investigations confirmed the diagnosis of CML and the patient was started on appropriate therapy.

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Uncontrolled per rectal bleeding in chronic myeloid leukaemia: a mere coincidence or a dangerous sign report of an unusual case

International Surgery Journal ◽

10.18203/2349-2902.isj20204158 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3466

Author(s):

S. Manwar Ali ◽

Pradeep K. Singh ◽

Pranav B. Joshi ◽

Prabhash K. Naik

Keyword(s):

Chronic Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Rectal Bleeding ◽

Conservative Management ◽

Myeloproliferative Neoplasm ◽

Emergency Operation ◽

Bone Marrow Examination ◽

Interesting Case ◽

Outpatient Departments ◽

High Index Of Suspicion

Bleeding haemorrhoids present commonly to surgical outpatient departments (OPDs) and sometimes in emergency. Most often conservative management suffices but infrequently the patients can land up in emergency operation theatre for uncontrolled bleeding. Some haematological disorders can also present with rectal bleeding and amongst them Chronic myeloid leukaemia (CML), a haematological malignancy, presenting as bleeding per rectum has been not been reported so far, though instances of CML with gingival bleed, epistaxis have been reported. CML per se is known to be asymptomatic (40% cases) and bleeding is rarely seen. Here we present an interesting case of an emergency hemorrhoidal bleed that was subsequently diagnosed as CML. The patient after failed conservative management for bleeding haemorrhoids was taken up for emergency haemorrhoidectomy and again a relook under general anaesthesia in the post-operative period as he continued to ooze. The total leucocyte counts which were initially high continued to rise further and the bone marrow examination was reported as chronic myeloproliferative neoplasm and the excised mass was consistent with haemorrhoids. Rectal bleeding associated with CML is so far unreported even though bleeding is seen due to platelet dysfunction from gums and nose in chronic phases of the disease. A high index of suspicion is needed particularly with deranged haematological parameters for considering a diagnosis of these rare presentations. and anaesthesia.

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Atypical chronic myeloid leukaemia – a rare subtype of myelodysplastic/myeloproliferative neoplasm

Współczesna Onkologia ◽

10.5114/wo.2018.74388 ◽

2018 ◽

Vol 22 (1) ◽

pp. 14-19

Author(s):

Joanna E. Drozd-Sokołowska ◽

Anna Waszczuk-Gajda ◽

Krzysztof Mądry ◽

Jadwiga Dwilewicz-Trojaczek

Keyword(s):

Chronic Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Myeloproliferative Neoplasm

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Faculty Opinions recommendation of Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090381.543631 ◽

2007 ◽

Author(s):

Michael Deininger

Keyword(s):

Chronic Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Clinical Evaluation

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Haematological Disease Pattern at Specialized HOPD - A study in Bangabandhu Sheikh Mujib Medical University

Haematology Journal of Bangladesh ◽

10.37545/haematoljbd201817 ◽

2018 ◽

Vol 2 (02) ◽

pp. 39-41

Author(s):

Md. Rafiquzzaman Khan ◽

Arifur Rahman ◽

Khaza Amirul Islam ◽

AQM Ashraful Haque ◽

Masuda Begum

Keyword(s):

Iron Deficiency ◽

Chronic Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Iron Deficiency Anaemia ◽

Beta Thalassemia ◽

Female Ratio ◽

Deficiency Anaemia ◽

Beta Thalassaemia ◽

Hb E ◽

Medical University

The aim of this retrospective observational study was to observe the pattern and frequency of haematological disorders among the patients attending in the specialized Haematology outpatient Department (HOPD) in Bangabandhu Sheikh Mujib Medical University. Consecutive 201 patients over the period of one year were enrolled. Their age ranged from 01 to 72 years with a mean age of 36.76 years. Most of the patients (34.3%) were in between the ages of 31 to 45 years followed by 16 to 30 years (27.9%). Male to female ratio was 0.65. Iron deficiency anaemia is the most common (24.9%) followed by chronic myeloid leukaemia (11.9%), Hb E beta thalassaemia (9.5%), idiopathic thrombocytopenic purpura (9.5%), beta thalassaemia trait (7.0%), Hb E trait (5.5 %), aplastic anaemia (5.0%), multiple myeloma (3.5%), acute lymphoblastic leukaemia (3.0%). Acute myeloid leukaemia, autoimmune haemolytic anaemia, chronic lymphocytic leukaemia, anaemia of chronic disease, non-Hodgkin lymphoma, polycythaemia, beta thalassemia major and alpha thalassemia was 2.5%, 2.5%, 2.0%, 1.5%, 1.5%, 1.5%, 1.0% and 1.0%, respectively. In the present study, we observed that iron deficiency anaemia the most common non-malignant disease and chronic myeloid leukaemia is the common haematological malignancy.

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