Concomitant malignancies in the neck: follicular dendritic cell sarcoma; a rare tumour presenting as a right-sided neck nodal mass and papillary carcinoma thyroid

2021 ◽  
Vol 14 (11) ◽  
pp. e244175
Author(s):  
Suhas Umakanth ◽  
Badareesh Lakshminarayana ◽  
Ranjini Kudva

Follicular dendritic cell sarcoma is a rare low-grade sarcoma of mesenchymal origin. It involves the lymph nodes more commonly and rarely extranodal sites. The most common lymph node is cervical and usually presents as a painless asymptomatic mass. More often, it is a misdiagnosis, and there is a delay in treatment. It is rarely associated with Castleman disease, myasthenia gravis. Diagnosis of this condition is by histopathology and immunochemistry. Surgery is the primary modality of treatment, and adjuvant therapy has been tried with no definite trials due to the rarity of the disease. Here, we report a case of concomitant follicular dendritic sarcoma of the right cervical lymph node and papillary carcinoma of the thyroid managed in our institute. There was a line of investigations approaching towards a diagnosis, and she underwent total thyroidectomy and right modified radical neck dissection.

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092043
Author(s):  
Ting Zhang ◽  
Liang He ◽  
Zhihong Wang ◽  
Wenwu Dong ◽  
Wei Sun ◽  
...  

Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the germinal centers and is characterized by the neoplastic proliferation of spindled to ovoid cells. As there have been only five cases reported in the literature until now, the diagnostic and therapeutic information available to clinicians regarding thyroid FDCS is fairly limited. To our knowledge, this is the first case report of thyroid FDCS without a history of Hashimoto’s thyroiditis. A 48-year-old woman was found to have a slow-growing mass in the left thyroid. After total thyroidectomy and left modified radical neck dissection, the specimen demonstrated morphologic and immunohistochemical features of FDCS. The patient had a favorable prognosis with no evidence of disease 11 months after tumor excision.


2021 ◽  
pp. 1698-1705
Author(s):  
Seyed-ahmad Seyed-alagheband ◽  
Mohammad-kazem Shahmoradi ◽  
Omid-Ali Adeli ◽  
Tahereh Shamsi ◽  
Maryam Sohooli ◽  
...  

Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case of FDCS of the thyroid gland. A 63-year-old woman presented with a painless midline neck mass, enlarging for the last 4 months. Physical examination revealed a 6-cm nonmobile, firm, multinodular thyroid mass with palpable cervical lymphadenopathy. Due to high suspicion for thyroid malignancy, the patient underwent total thyroidectomy with bilateral modified radical neck dissection. Histologic evaluations revealed sheets of storiform eosinophilic tumoral cells with prominent nucleoli containing multinucleated giant cells, and subsequent immunohistochemistry showed immunoreactivity for CD4, CD21, CD35, CD45 (LCA), and CD68. The patient was started on 6 cycles of doxorubicin, ifosfamide, and radiotherapy. She has had monthly thyroid ultrasonography and contrast-enhanced thoracoabdominal CT scan every 3 months for detecting potential recurrence and/or metastasis screening. Fortunately, 8 months after the operation, the patient is alive without any signs of local or distant metastasis.


2014 ◽  
Vol 75 (11) ◽  
pp. 3147-3151
Author(s):  
Minori ISHII ◽  
Minoru TAKADA ◽  
Hiroko NOGUCHI ◽  
Tomoko MITSUHASHI ◽  
Fumitaka NAKAMURA ◽  
...  

2009 ◽  
Vol 59 (11) ◽  
pp. 809-812 ◽  
Author(s):  
Yosuke Yamada ◽  
Hironori Haga ◽  
Mako Hernandez ◽  
Kanako C. Kubota ◽  
Fumika Orii ◽  
...  

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