Atypical presentation of giant cell arteritis associated with SIADH: a rare association

2021 ◽  
Vol 14 (12) ◽  
pp. e246187
Author(s):  
Sadia Tariq ◽  
Sameh Jonny ◽  
Hanadi Asalieh

We present here an interesting case of a 67-year-old man with 3 weeks history of lethargy, loss of appetite, generalised weakness and weight loss. Following thorough investigations, occult malignancy was ruled out. Hyponatraemia was a consistent finding which needed further classification. Additional workup including cerebral imaging and neurophysiological studies excluded cerebral vascular events and myopathies. Vasculitis screening was undertaken, and the diagnostic dilemma was revealed by the temporal arteries Doppler ultrasound which showed classical ‘halo sign’. Diagnosis of temporal arteritis was made and linked with syndrome of inappropriate antidiuretic hormone secretion, which appears to be a rare association with few instances on record. Patient was treated with high dose of prednisolone with marked improvement of clinical features.

Cancer ◽  
1985 ◽  
Vol 55 (1) ◽  
pp. 44-46 ◽  
Author(s):  
Barbara Greenbaum-Lefkoe ◽  
Jeffrey G. Rosenstock ◽  
Jean B. Belasco ◽  
Thomas M. Rohrbaugh ◽  
Anna T. Meadows

1999 ◽  
Vol 24 (5) ◽  
pp. 571-572 ◽  
Author(s):  
S Sica ◽  
S Cicconi ◽  
F Sorà ◽  
P Chiusolo ◽  
N Piccirillo ◽  
...  

1980 ◽  
Vol 123 (5) ◽  
pp. 783-784 ◽  
Author(s):  
Asok Antony ◽  
William A. Robinson ◽  
Charles Roy ◽  
William Pelander ◽  
Robert Donohue

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3350 ◽  
Author(s):  
Manxia An ◽  
Yanying Ni ◽  
Xundou Li ◽  
Youhe Gao

Biomarkers are the measurable changes associated with a physiological or pathophysiological process. The content of urine frequently changes because it is not controlled by homeostatic mechanisms, and these alterations can be a source of biomarkers. However, urine is affected by many factors. In this study, vasoconstrictor and antidiuretic arginine vasopressin (AVP) were infused into rats using an osmotic pump. The rats’ urinary proteome after one week of infusion was analyzed by label-free LC-MS/MS. A total of 408 proteins were identified; among these proteins, eight and 10 proteins had significantly altered expression in the low and high dose groups, respectively, compared with the control group using the one-way ANOVA analysis followed by post hoc analysis with the least significant difference (LSD) test or Dunnett’s T3 test. Three differential proteins were described in prior studies as related to AVP physiological processes, and nine differential proteins are known disease biomarkers. Sixteen of the 17 differential proteins have human orthologs. These results suggest that we should consider the effects of AVP on urinary proteins in future urinary disease biomarker researches. The study data provide clues regarding underlying mechanisms associated with AVP for future physiological researches on AVP. This study provide a sensitive changes associated with AVP. However, the limitation of this result is that the candidate biomarkers should be further verified and filtered. Large clinical samples must be examined to verify the differential proteins identified in this study before these proteins are used as biomarkers for pathological AVP increased diseases, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH).


2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Rishi Raj ◽  
Aasems Jacob ◽  
Ajay Venkatanarayan ◽  
Mohankumar Doraiswamy ◽  
Manjula Ashok

Hyponatremia is a well-known medication related side effect of selective serotonin reuptake inhibitors; despite its association with escitalopram, the newest SSRI is very rare. We did a review of literature and came across only 14 reported case of this rare association of SIADH with escitalopram. We hereby report a case of a 93-year-old female who presented with generalized tonic-clonic seizure and was diagnosed with severe hyponatremia due to escitalopram-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). With this article, we want to emphasize clinicians about this rare side effect of escitalopram use and look for the risk factors leading to SIADH.


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