Probable mode of action of oral contraceptives.

In 2016, the number of pregnancies in women in England and Wales under 18 reached an all-time low since records began in 1969, although over the past decade legal abortions have increased in all ages except those over 40. Approximately 60% of women undergoing a termination of pregnancy report using a method of contraception at the time of conception – usually oral contraceptives or condoms. Long-active methods of contraception are the most reliable in preventing pregnancy. This chapter details the different methods of contraception, mode of action, benefits and disadvantages of different methods, efficacy, how to start and switch methods, including contraception post-partum and in women living with HIV infection.

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A possible mode of action of progestagen-only oral contraceptives

Contraception ◽

10.1016/0010-7824(74)90025-0 ◽

1974 ◽

Vol 9 (2) ◽

pp. 123-131 ◽

Cited By ~ 10

Author(s):

B. Boettcher

Keyword(s):

Oral Contraceptives ◽

Mode Of Action

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Oral Contraceptives: Their Mode of Action and Dermatologic Applications

SKINmed Dermatology for the Clinician ◽

10.1111/j.1540-9740.2005.03955.x ◽

2005 ◽

Vol 4 (2) ◽

pp. 101-106 ◽

Cited By ~ 1

Author(s):

Milena Pitashny ◽

Helena Martinez de Morentin ◽

Sarah Brenner

Keyword(s):

Oral Contraceptives ◽

Mode Of Action

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Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066917 ◽

1971 ◽

Vol 29 ◽

pp. 570-571

Author(s):

E. A. Elfont ◽

R. B. Tobin ◽

D. G. Colton ◽

M. A. Mehlman

Keyword(s):

Chemical Composition ◽

Rat Liver ◽

Future Study ◽

Mode Of Action ◽

Liver Mitochondria ◽

Rat Liver Mitochondria ◽

Effective Inhibitor ◽

Biochemical Effects ◽

Glycerophosphate Dehydrogenase ◽

Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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