STUDIES ON THE MODE OF ACTION OF ORAL CONTRACEPTIVES: EFFECT OF CHLORMADINONE ON PITUITARY FSH AND LH CONTENTS OF THE FEMALE RAT

1. Testosterone (1 mg/kg body-weight per d) given subcutaneously to female rats increased their growth rate and food conversion efficiency but not their food intake compared with that of the placebo-oil controls. A higher dose of testosterone (10 mg/kg body-weight per d) failed to increase the daily weight gain.2. The increased growth rate of the testosterone-treated rats appeared to occur in the whole body and not specifically in muscle. There were no significant changes in body composition.3. The fractional synthetic rate of gastrocnemius muscle protein was higher in the hormone-treated rats than in controls. This contrasts with previous results for the anabolic agent trenbolone acetate and reflects differences in the mode of action of these two different steroids, both with androgenic properties.

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Probable mode of action of oral contraceptives.

BMJ ◽

10.1136/bmj.2.5475.1394 ◽

1965 ◽

Vol 2 (5475) ◽

pp. 1394-1399 ◽

Cited By ~ 26

Author(s):

E. Diczfalusy

Keyword(s):

Oral Contraceptives ◽

Mode Of Action

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A METHOD FOR STUDYING THE MODE OF ACTION OF ORAL CONTRACEPTIVES

Obstetrical & Gynecological Survey ◽

10.1097/00006254-196504000-00035 ◽

1965 ◽

Vol 20 (2) ◽

pp. 305-306

Author(s):

P. S. BROWN ◽

M. WELLS ◽

F. J. CUNNINGHAM

Keyword(s):

Oral Contraceptives ◽

Mode Of Action

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A METHOD FOR STUDYING THE MODE OF ACTION OF ORAL CONTRACEPTIVES

The Lancet ◽

10.1016/s0140-6736(64)90335-6 ◽

1964 ◽

Vol 284 (7357) ◽

pp. 446-447 ◽

Cited By ~ 11

Author(s):

P.S. Brown ◽

M. Wells ◽

F.J. Cunningham

Keyword(s):

Oral Contraceptives ◽

Mode Of Action

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Contraception, including contraception for women living with HIV

Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health ◽

10.1093/med/9780198783497.003.0034 ◽

2019 ◽

pp. 381-428

Keyword(s):

Hiv Infection ◽

Oral Contraceptives ◽

Mode Of Action ◽

Post Partum ◽

Termination Of Pregnancy ◽

England And Wales ◽

The Past ◽

Women Living With Hiv ◽

Living With Hiv

In 2016, the number of pregnancies in women in England and Wales under 18 reached an all-time low since records began in 1969, although over the past decade legal abortions have increased in all ages except those over 40. Approximately 60% of women undergoing a termination of pregnancy report using a method of contraception at the time of conception – usually oral contraceptives or condoms. Long-active methods of contraception are the most reliable in preventing pregnancy. This chapter details the different methods of contraception, mode of action, benefits and disadvantages of different methods, efficacy, how to start and switch methods, including contraception post-partum and in women living with HIV infection.

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