scholarly journals Assessment of burden of drug-resistant tuberculosis at a tertiary care centre in northern India: a prospective single centre cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e044096
Author(s):  
Richa Misra ◽  
Vasudha Kesarwani ◽  
Alok Nath
Keyword(s):  
Tertiary Care ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Second Line ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Northern India ◽  
National Strategic Plan ◽  
Resistant Tuberculosis ◽  
Probe Assay

ObjectivesWe aim to define the burden of rifampicin monoresistant tuberculosis (TB) at a tertiary care centre in northern India as well as determine the second-line drug susceptibilities (SL-DST) in a subset of patients.MethodsA total of 3045 pulmonary (n=1883) and extrapulmonary (n=1162) samples from likely patients with TB were subjected to microscopy, culture and the Xpert MTB/RIF assay from March 2017 to June 2019. SL-DST testing by line probe assay version 2 for fluoroquinolones (FQs) and second-line injectable drugs were performed on 62 samples.ResultsOut of 3045 samples processed in our laboratory during the study period, 36.1% (1101/3045) were positive for Mycobacterium tuberculosis complex (MTBC) and 21.6% were rifampicin monoresistant (223/1032). The rate of rifampicin resistance in pulmonary samples was 23.5% (166/706) and in extrapulmonary cases, it was 17.4% (57/326). Out of 62 cases included for second-line testing, 48 were resistant to FQs (77.4%) while 11 were extensively drug resistant.ConclusionsIndia urgently needs to arrest an emerging multidrug-resistant TB epidemic with associated resistance to FQs. A robust surveillance system is needed to execute the National Strategic Plan for 2017–2025.

Epidemiological and behavioural correlates of drug-resistant tuberculosis in a Tertiary Care Centre, Delhi, India

2019 ◽  
Vol 66 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Kevisetuo A. Dzeyie ◽  
Saurav Basu ◽  
Tanzin Dikid ◽  
Anuj K. Bhatnagar ◽  
L.S. Chauhan ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Drug Resistant ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis

STUDY OF DRUG SUSPECTIBILITY AND RESISTANCE PATTERN OF MULTI-DRUG RESISTANT TUBERCULOSIS PATIENTS AT A TERTIARY CARE CENTRE-A RETROSPECTIVE STUDY

2021 ◽  
pp. 30-31
Author(s):  
Robin John ◽  
Hafiz Deshmukh ◽  
Sunil Jadhav ◽  
Ashish Deshmukh ◽  
Shivprasad Kasat ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Resistance Pattern ◽  
Drug Resistant ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Drug Resistant Tuberculosis ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis ◽  
Mdr Tb

OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have registered under RNTCP from Jan 2018 to Jan 2020.Drug resistant patterns will be studied over a span of 3 years. RESULTS: In this study most of the patients of MDR-TB patients were of female gender with maximum involvement of pulmonary origin. Rifampicin resistance was most common. CONCLUSION: The present study emphasizes on the need for strengthening of laboratory services in diagnosis of MDR-TB, adequate and strict drug regimes to be followed in order to curtain the MDR-TB cases.

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