Anticholinestisrase enedrops in chronic simple glaucoma

1966 ◽  
Vol 4 (4) ◽  
pp. 14-15
Keyword(s):  
Visual Field ◽  
Trabecular Meshwork ◽  
Open Angle Glaucoma ◽  
Direct Action ◽  
Ciliary Muscle ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Medical Control ◽  
Ocular Pressure ◽  
Aqueous Outflow

The medical control of chronic simple (open-angle) glaucoma is becoming more popular, and newer and more potent drugs have been produced to reduce the intra-ocular pressure. The anticholinesterases are one such group of drugs; they potentiate acetylcholine and increase aqueous outflow from the eye, perhaps by stimulating the ciliary muscle which pulls on the scleral spur, or by direct action on parasympathetic end-organs in the trabecular meshwork. The effect lasts many hours or even several days, thus achieving the uninterrupted control of intra-ocular pressure essential to prevent further loss of visual field.

Topical treatment of chronic simple glaucoma

1964 ◽  
Vol 2 (5) ◽  
pp. 18-19
Keyword(s):  
Visual Field ◽  
Topical Treatment ◽  
Aqueous Humour ◽  
Open Angle Glaucoma ◽  
Ciliary Muscle ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Muscle Contract ◽  
Ocular Pressure

In chronic simple (open-angle) glaucoma loss of visual field may be prevented by improving the outflow of aqueous humour from the eye and thus lowering the raised intra-ocular pressure. This is achieved mainly by miotic drugs which constrict the pupil and make the ciliary muscle contract. These either mimic acetylcholine, acting directly on the ciliary muscle, or inhibit cholinesterase and so allow acetylcholine to accumulate.

scholarly journals Effect of trabeculectomy and canaloplasty on intra-ocular pressure modifications after postural changes in open-angle glaucoma

2014 ◽  
Vol 92 (6) ◽  
pp. e498-e499 ◽  
Author(s):  
Luciano Quaranta ◽  
Elena Biagioli ◽  
Ivano Riva ◽  
Claudia Tosoni ◽  
Paolo Brusini ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Postural Changes ◽  
Ocular Pressure

Timolol eyedrops (timoptol) for glaucoma

1980 ◽  
Vol 18 (4) ◽  
pp. 13-14
Keyword(s):  
Ocular Hypertension ◽  
Adverse Reactions ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Timolol Maleate ◽  
Topical Preparation ◽  
Intra Ocular Pressure ◽  
Ocular Pressure ◽  
Β Blocker ◽  
Adrenergic Blocking

β-Adrenergic blocking agents given systemically reduce intra-ocular pressure,1 but until recently their topical use in glaucoma was limited by ocular and systemic adverse reactions. Timolol maleate eyedrops (Timoptol - MSD) is the first topical preparation of a β-blocker that is sufficiently well tolerated to be useful in chronic simple (open-angle) glaucoma and in ocular hypertension (raised intra-ocular pressure without damage to the eye).

Demographic and clinical characteristics of patients with glaucoma in a tertiary eye facility in Ghana

2020 ◽  
Vol 79 (1) ◽  
Author(s):  
Doreen Nelson-Ayifah ◽  
Khathutshelo P. Mashige
Keyword(s):  
Visual Acuity ◽  
Ethnic Groups ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Open Angle Glaucoma ◽  
Angle Closure ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Ocular Pressure ◽  
Cup To Disc Ratio

Background: Ghana has been reported to have the second highest prevalence of glaucoma worldwide.Aim: Because of glaucoma causing numerous cases of irreversible blindness, there is the need for baseline data for glaucoma characteristics among Ghanaians. This study was conducted to determine the demographic and clinical characteristics of glaucoma patients in a tertiary eye centre.Setting: The setting for this study is the eye clinic of the Agogo Presbyterian Hospital, which is situated in the Ashanti Region of Ghana.Methods: The medical records of patients who attended the eye centre from January 2013 to December 2017 were reviewed. The data collected included the demographic variables and clinical characteristics of patients diagnosed with glaucoma.Results: Of the 1100 medical records reviewed, 311 were diagnosed with glaucoma. Of the 311 patients, 159 (51.1%) were males and 152 (48.9%) were females, with their ages ranging from 11 to 104 years (mean = 60 ± 18.1 years). Primary open-angle, secondary, juvenile and primary angle-closure glaucomas accounted for 81.6%, 11%, 3.8% and 3.6%, respectively, of all cases of glaucoma. The average intra-ocular pressure was 28.2 ± 11 mmHg. The cup-to-disc ratio and visual acuity varied significantly among the various ethnic groups (p 0.05), while the average intra-ocular pressure did not (p 0.05). Timolol was the first line of treatment for 91.4% cases of glaucoma.Conclusion: Primary open-angle glaucoma is the predominant type in this population, with the clinical characteristics of visual acuity and cup-to-disc ratio varying among the different Ghanaian ethnic groups. There is a need for population-based epidemiologic studies to validate the data collected in this hospital-based study.

scholarly journals Physiological Bases of Electric Stimulation as a New Approach to Glaucoma IOP Control

2021 ◽  
Author(s):  
Luis Nino-de-Rivera ◽  
Diego Cervera ◽  
Paola Castillo-Juarez
Keyword(s):  
Electric Stimulation ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Ionic Channels ◽  
Open Angle ◽  
New Approach ◽  
Intra Ocular Pressure ◽  
Voltage Dependent ◽  
Ocular Pressure ◽  
One Year

This Chapter focuses in the electrophysiological bases to support Trans Palpebral Electrical Stimulation TPES as a new alternative to control Intraocular Pressure IOP. Primary open Angle Glaucoma POAG is described in our approach as a dysfunction of the membrane potential of TM cells due to the dysfunction of the Maxi potassium depended Calcium Channels BKCa2+ of the Trabecular Mesh TM. We review through the paper the main contributions about Trabecular mesh dysfunction related with Voltage dependent ionic channels. We also present in this paper new results in controlling intra ocular pressure IOP during one year of trans palpebral Electric stimulation in patients with Primary open-angle glaucoma (POAG).

scholarly journals The Effects of Prostaglandin Analogs on Intraocular Pressure in Human Eye for Open Angle Glaucoma

2020 ◽  
Vol 10 (2) ◽  
pp. 176-180
Author(s):  
Shabab Akbar ◽  
Sapna Ratan Shah
Keyword(s):  
Fluid Flow ◽  
Intraocular Pressure ◽  
Aqueous Humor ◽  
Trabecular Meshwork ◽  
Ciliary Body ◽  
Open Angle Glaucoma ◽  
Posterior Chamber ◽  
Open Angle ◽  
Permeable Channel ◽  
Aqueous Outflow

The effects of Prostaglandin Analogs on intraocular pressure and increased aqueous outflow via trabecular meshwork into the schlemm’s canal has been studied in this present research paper. Aqueous humor is an outflow, which flows at the back of the iris in the posterior chamber all the way through the pupil aperture, out into the anterior chamber, and drain from the eye via drainage slope. The eye keeps on making aqueous humor in the ciliary body and it passes through the trabecular meshwork into the scheme of the canal, the key drainage from the eye and it finally goes to the “collector channels” and due to the less amount of aqueous humor fluid flow from the drainage angle, the pressure in the eye starts to increase. For this study, the canal of Schlemm is assumed as a permeable channel. And it is connected by trabecular meshwork. The inner layer of the canal's wall has been assumed as permeable. And the aqueous humor drains into the canal through this porous tissue wall. The objective of this paper is to discuss the effect of prostaglandin analogs on intraocular pressure as the Prostaglandin Analogs work by increasing the outflow of aqueous from the eye.

scholarly journals Twenty-four-hour pattern of intra-ocular pressure in untreated patients with primary open-angle glaucoma

2016 ◽  
Vol 94 (6) ◽  
pp. e460-e467 ◽  
Author(s):  
Jingyi Cheng ◽  
Xiangmei Kong ◽  
Ming Xiao ◽  
Xinghuai Sun
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Intra Ocular Pressure ◽  
Ocular Pressure
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