scholarly journals PTU-031 Drug induced liver injury among patients with multiple sclerosis treated with alemtuzumab- a single-centre experience

2019 ◽  
Author(s):  
Liane Rabinowich ◽  
Eli Silber ◽  
Peter Brex ◽  
Deborah Clark ◽  
Gosia Kuran ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Single Centre ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Single Centre Experience

Drug Induced Liver Injury: A Single Centre Experience

2014 ◽  
Vol 4 ◽  
pp. S76
Author(s):  
Jimmy Narayan ◽  
Shivaram Prasad Singh ◽  
Ayaskanta Singh ◽  
Debasis Misra ◽  
Pradeep Kumar Padhi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Single Centre ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Single Centre Experience

Liver injury associated with dimethyl fumarate in multiple sclerosis patients

2017 ◽  
Vol 23 (14) ◽  
pp. 1947-1949 ◽  
Author(s):  
Monica A Muñoz ◽  
Corrinne G Kulick ◽  
Cindy M Kortepeter ◽  
Robert L Levin ◽  
Mark I Avigan
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Health Professionals ◽  
Elevated Serum ◽  
Dimethyl Fumarate ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Post Marketing ◽  
Clinically Significant ◽  
Multiple Sclerosis Patients

Background: In pre-approval trials, there was an increased incidence of mild, transient elevations of liver aminotransferases in study subjects treated with dimethyl fumarate (DMF). Objective/methods: To evaluate post-marketing cases of drug-induced liver injury associated with DMF. Results: We identified 14 post-marketing cases of clinically significant liver injury. Findings included newly elevated serum liver aminotransferase and bilirubin levels that developed as early as a few days after the first dose of DMF. The pattern of liver injury was primarily hepatocellular. No cases resulted in liver failure. Conclusion: Health professionals should be alerted to possible serious liver injury in patients receiving DMF.

scholarly journals Drug induced liver injury secondary to interferon-beta (IFN-β) in multiple sclerosis

2006 ◽  
Vol 5 (1) ◽  
pp. 56-59 ◽  
Author(s):  
V. Byrnes ◽  
N. Afdhal ◽  
T. Challies ◽  
P.E. Greenstein
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Interferon Beta ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals A Case of Drug-Induced Liver Injury Secondary to Natalizumab

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Phillip P. Santoiemma ◽  
Haripriya Maddur ◽  
Christopher M. Moore
Keyword(s):  
Multiple Sclerosis ◽  
Abdominal Pain ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Nausea And Vomiting ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Caucasian Female

A 33-year-old Caucasian female with relapsing-remitting multiple sclerosis presented with abdominal pain, nausea, and vomiting and was found to have acute liver injury. After thorough investigation, she was diagnosed with drug-induced liver injury (DILI) thought secondary to redosing of Natalizumab therapy.

Characteristics associated with drug-induced liver injury from interferon beta in multiple sclerosis patients

2014 ◽  
Vol 13 (10) ◽  
pp. 1305-1317 ◽  
Author(s):  
Kaarina Kowalec ◽  
Elaine Kingwell ◽  
Eric M Yoshida ◽  
Ruth Ann Marrie ◽  
Marcelo Kremenchutzky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Interferon Beta ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Multiple Sclerosis Patients

scholarly journals Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis

2013 ◽  
Vol 1 (4) ◽  
pp. 232470961351749 ◽  
Author(s):  
Attila Onmez ◽  
Ahmet Tarik Eminler ◽  
Hasan Ergenç ◽  
Meltem Baykara ◽  
Ihsan Uslan ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Liver Injury ◽  
Glatiramer Acetate ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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