scholarly journals THE ROLE OF A SINGLE-COMPOUND PREPARATION IN COMPLIANCE AND DYNAMIC BLOOD PRESSURE CHANGES IN PATIENTS WITH MILD TO MODERATE HYPERTENSION

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E253.3-E254
Author(s):  
Zhaochuan Liu ◽  
Junling Wang
Keyword(s):  
Blood Pressure ◽  
Moderate Hypertension ◽  
Single Compound ◽  
Pressure Changes

Role of the Gonads in Control of Blood Pressure in Chickens

1957 ◽  
Vol 190 (1) ◽  
pp. 54-56 ◽  
Author(s):  
Robert K. Ringer ◽  
P. D. Sturkie ◽  
H. S. Weiss
Keyword(s):  
Blood Pressure ◽  
Sex Difference ◽  
Ovarian Activity ◽  
Adult Chicken ◽  
Sexual Stimulation ◽  
Gonadotrophin Secretion ◽  
Pressure Changes

Blood pressure changes in gonadectomized and gonadotrophin-treated chicks were utilized to determine the role of the gonads in establishing and maintaining the sex difference in pressure of the adult chicken. By the 23rd week, 4–5 weeks after the normal rise in male pressure, both capon and poulard pressures had climbed to near the male level and significantly above the female. This confirms that androgen is not essential to the rise in pressure, and indicates that other than ovarian activity, nothing inherent in the female prevents the rise. Furthermore, elevated poulard pressures could be depressed to near female levels with estrogen or 2-amino,5-nitrothiazole, presumably through suppression of pituitary gonadotrophin secretion. Exogenous gonadotrophin failed to change the pressure of the chick prematurely, despite marked sexual stimulation, suggesting that chronological maturation, possibly independent of the pituitary-gonad interrelationship, is a prerequisite.

The role of brain acetylcholine in GABAA receptor antagonist-induced blood-pressure changes in rat

1996 ◽  
Vol 317 (2-3) ◽  
pp. 301-307 ◽  
Author(s):  
Tahir Tellioǧlu ◽  
Serap Akin ◽  
Uǧur Özkutlu ◽  
Şule Oktay ◽  
Filiz Onat
Keyword(s):  
Blood Pressure ◽  
Receptor Antagonist ◽  
Gabaa Receptor ◽  
Gabaa Receptor Antagonist ◽  
Pressure Changes ◽  
Brain Acetylcholine

scholarly journals Renal sodium handling and blood pressure changes in gestational protein-restricted offspring: Role of renal nerves and ganglia neurokinin expression

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179499 ◽  
Author(s):  
Augusto H. Custódio ◽  
Marcelo C. de Lima ◽  
Bárbara Vaccari ◽  
Patrícia A. Boer ◽  
José A. R. Gontijo
Keyword(s):  
Blood Pressure ◽  
Renal Nerves ◽  
Renal Sodium Handling ◽  
Pressure Changes ◽  
Sodium Handling

scholarly journals Cardiac sympathetic burden reflects Parkinson disease burden, regardless of high or low orthostatic blood pressure changes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sang-Won Yoo ◽  
Joong-Seok Kim ◽  
Yoon-Sang Oh ◽  
Dong-Woo Ryu ◽  
Seunggyun Ha ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Disease Burden ◽  
Assessment Tools ◽  
Sympathetic Denervation ◽  
Tilt Test ◽  
Myocardial Uptake ◽  
Orthostatic Blood Pressure ◽  
Pressure Changes ◽  
Cardiac Sympathetic Denervation

AbstractReduced uptake of 123I-meta-iodobenzylguanidine (123I-MIBG) and orthostatic hypotension (OH) are independently associated with worse clinical outcomes of Parkinson’s disease (PD). However, their interactive influence on PD has not been studied. The role of 123I-MIBG myocardial uptake, as a biomarker of PD severity, was investigated, conditional on the mediating effects of OH. A total of 227 PD patients were enrolled. Their motor and nonmotor aspects were assessed with standardized tools. Global disease burden was estimated by averaging the scaled z-scores of the assessment tools. Every patient went through 123I-MIBG scan, and OH was evaluated with the head-up tilt-test. The mediating role of orthostatic blood pressure changes (ΔBP) on the association between cardiac sympathetic denervation and disease burden was investigated. Low heart-to-mediastinum (H/M) ratio with less than 1.78 was seen in 69.6% of the patient population, and 22.9% of patients had OH. Low H/M ratio was associated with OH, and these patients had worse disease burden than subjects with normal 123I-MIBG uptake (global composite z-score: normal 123I-MIBG vs. abnormal 123I-MIBG; −0.3 ± 0.5 vs. 0.1 ± 0.7; p < 0.001). The mediation models, controlled for age and disease duration, revealed that the delayed H/M ratio and global composite score were negatively associated, irrespective of orthostatic ΔBP. Adverse relationship between cardiac sympathetic denervation and disease burden was shown without any interference from orthostatic blood pressure fluctuations. This result suggested that extracranial cardiac markers might reflect disease burden, regardless of labile blood pressure influence.

Systolic Wall Stress and Ventricular Arrhythmia: The Role of Acute Change in Blood Pressure in the Isolated Working Rat Heart

1990 ◽  
Vol 79 (5) ◽  
pp. 499-504 ◽  
Author(s):  
M. A. James ◽  
J. V. Jones
Keyword(s):  
Blood Pressure ◽  
Wall Stress ◽  
Pressure Change ◽  
Acute Change ◽  
Wistar Kyoto ◽  
Acute Changes ◽  
Pressure Changes ◽  
Working Heart ◽  
Ventricular Ectopics

1. The effect of a sudden acute change in blood pressure upon arrhythmia provocation has been studied in an isolated working heart model from the Wistar—Kyoto strain of rat. Twenty-four hearts were studied. 2. They were perfused with two different, modified, Krebs—Henseleit solutions at a fixed left atrial pressure. 3. Acute changes in pressure, both increases and decreases, were arrhythmogenic. Whilst ectopic activity was more predictably produced by pressure reductions, this consisted of simple ventricular ectopics only. Pressure increases, in contrast, were capable of provoking more complex and sustained arrhythmias. 4. The effect of pressure changes were highly dependent upon electrolyte concentrations in the perfusate. Low potassium and magnesium concentrations increased the amount of arrhythmia provoked by pressure increases but tended to reduce that provoked by pressure reductions. 5. We conclude that the direct effect of an acute change in pressure upon the myocardium is arrhythmogenic. However, the myocardial response to a pressure change is interdependent upon prevailing electrolyte concentrations.

The role of sodium restriction in the management of hypertension

1986 ◽  
Vol 64 (6) ◽  
pp. 786-792 ◽  
Author(s):  
Trefor Morgan ◽  
Carol Nowson
Keyword(s):  
Blood Pressure ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Population Studies ◽  
Severe Hypertension ◽  
Sodium Intake ◽  
Regression Line ◽  
Elevated Blood ◽  
Sodium Restriction

More than 50 studies have investigated the effect of altered sodium intake on blood pressure. A regression line drawn through the change in blood pressure and change in sodium intake indicates that blood pressure alters about 10 mmHg (1 mmHg = 133.322 Pa) for every 100 mmol/day alteration in sodium intake, a change similar to that observed in between-population "studies." The studies that have failed to show a change in blood pressure have usually been in people with a blood pressure less than 130/90 mmHg. Normotensive people appear to tolerate a higher intake of sodium before blood pressure rises, but if increased sufficiently, blood pressure rises in most people. Sodium restriction reduces blood pressure in people with severe hypertension, moderate hypertension and mild hypertension. It may be the cause of blood pressure increase associated with age and the reason for the higher prevalence of hypertension and vascular disease in Western communities. Sodium restriction should be used to treat people with elevated blood pressure.

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