ASSA13-14-25 The Difference of Blood Pressure and Left Ventricular Hypertrophy Among Spontaneously Hypertensive Rats with Treatment of Metoprolol, Amlodipine and Benazepril in Cold Stress

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A66.1-A66
Author(s):  
Su Hai ◽  
Sun Chuanfu ◽  
Wang Yunkai ◽  
Wang Jiwei ◽  
Xiong Qiang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Cold Stress ◽  
Spontaneously Hypertensive Rats ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
The Difference

scholarly journals Effect of renal denervation procedure on left ventricular hypertrophy of hypertensive rats and its mechanisms

2012 ◽  
Vol 27 (11) ◽  
pp. 815-820 ◽  
Author(s):  
Weihong Jiang ◽  
Lihua Tan ◽  
Yunzhong Guo ◽  
Xiaogang Li ◽  
Xiaohong Tang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Protein Expression ◽  
Spontaneously Hypertensive Rats ◽  
Renal Denervation ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Tnf Α

PURPOSE: To investigate the effect of renal denervation (RDN) on the blood pressure, left ventricular hypertrophy and myocardial expression of TLR4/NF-κB in spontaneously hypertensive rats (SHR). METHODS: A total of 36 SHR were randomly assigned into control group (D0), RDN group (D) and sham group (S). 12 WKY rats of same age served as controls (WKY group). Rats in the D0 and WKY groups were sacrificed, but rats in the D and S group were sacrificed at one week and six weeks after surgery. The heart was collected and the left ventricle weighted followed by calculation of left ventricular mass index (LVMI). RESULTS: In the D0 group, the blood pressure, LVMI and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were markedly higher than that in the WKY group (p<0.05). In the D1 and D2 group, the LVMI, NE and protein expression of TLR4, NF-κB, TNF-α and IL-6 in the myocardium were significantly reduced (p<0.05). CONCLUSION: Renal denervation can significantly delay the progression of left ventricular hypertrophy in spontaneously hypertensive rats, which may be attributed to the not only the suppression of sympathetic activity and attenuation of pressure load but the improvement of myocardial immuno-inflammation.

scholarly journals Cardiac Thyrotropin-Releasing Hormone Mediates Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

Hypertension ◽  
2011 ◽  
Vol 57 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Mariano L. Schuman ◽  
Maria S. Landa ◽  
Jorge E. Toblli ◽  
Ludmila S. Peres Diaz ◽  
Azucena L. Alvarez ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Spontaneously Hypertensive Rats ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Thyrotropin Releasing Hormone ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Releasing Hormone
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