scholarly journals A NOVEL ROLE OF PLASMA MEMBRANE CALCIUM ATPASE 4 AS A NEGATIVE-REGULATOR OF VEGF-INDUCED ANGIOGENESIS

Heart ◽  
2014 ◽  
Vol 100 (Suppl 4) ◽  
pp. A17.1-A17
Author(s):  
RR Baggott ◽  
A Alfranca ◽  
MD López-Maderuelo ◽  
TMA Mohamed ◽  
A Escolano ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Calcium Atpase ◽  
Negative Regulator ◽  
Plasma Membrane Calcium Atpase

scholarly journals Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4+ T-Cell Compartments

2021 ◽  
Vol 12 ◽  
Author(s):  
Maylin Merino-Wong ◽  
Barbara A. Niemeyer ◽  
Dalia Alansary
Keyword(s):  
Plasma Membrane ◽  
T Cell ◽  
Immune Responses ◽  
Chromatin Immunoprecipitation ◽  
Expression Patterns ◽  
Calcium Atpase ◽  
Cd4 T Cell ◽  
Plasma Membrane Calcium Atpase ◽  
Cell Compartments

Immune responses involve mobilization of T cells within naïve and memory compartments. Tightly regulated Ca2+ levels are essential for balanced immune outcomes. How Ca2+ contributes to regulating compartment stoichiometry is unknown. Here, we show that plasma membrane Ca2+ ATPase 4 (PMCA4) is differentially expressed in human CD4+ T compartments yielding distinct store operated Ca2+ entry (SOCE) profiles. Modulation of PMCA4 yielded a more prominent increase of SOCE in memory than in naïve CD4+ T cell. Interestingly, downregulation of PMCA4 reduced the effector compartment fraction and led to accumulation of cells in the naïve compartment. In silico analysis and chromatin immunoprecipitation point towards Ying Yang 1 (YY1) as a transcription factor regulating PMCA4 expression. Analyses of PMCA and YY1 expression patterns following activation and of PMCA promoter activity following downregulation of YY1 highlight repressive role of YY1 on PMCA expression. Our findings show that PMCA4 adapts Ca2+ levels to cellular requirements during effector and quiescent phases and thereby represent a potential target to intervene with the outcome of the immune response.

scholarly journals BS53 The role of plasma membrane calcium atpase 4 (PMCA4) in vascular remodelling during abdominal aortic aneurysm formation

2019 ◽  
Author(s):  
Kinza Khan ◽  
Miguel R Campanero ◽  
James Cotton ◽  
Juan Miguel Redondo ◽  
Angel L Armesilla
Keyword(s):  
Plasma Membrane ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Calcium Atpase ◽  
Vascular Remodelling ◽  
Plasma Membrane Calcium Atpase ◽  
Aneurysm Formation ◽  
Abdominal Aortic

scholarly journals P6 The role of plasma membrane calcium atpase 1 in angiogenesis

2018 ◽  
Author(s):  
AM Njegic ◽  
EJ Cartwright
Keyword(s):  
Plasma Membrane ◽  
Calcium Atpase ◽  
Plasma Membrane Calcium Atpase

Role of Plasma Membrane Calcium ATPase Isoform 2 in Neuronal Function in the Cerebellum and Spinal Cord

2007 ◽  
Vol 1099 (1) ◽  
pp. 287-291 ◽  
Author(s):  
M. P. KURNELLAS ◽  
A. K. LEE ◽  
K. SZCZEPANOWSKI ◽  
S. ELKABES
Keyword(s):  
Spinal Cord ◽  
Plasma Membrane ◽  
Calcium Atpase ◽  
Neuronal Function ◽  
Plasma Membrane Calcium Atpase

Role of the phospholipid environment in modulating the activity of the rat brain synaptic plasma membrane calcium ATPase

Biochemistry ◽  
1990 ◽  
Vol 29 (20) ◽  
pp. 4940-4950 ◽  
Author(s):  
Mira Hermoni-Levine ◽  
Hannah Rahamimoff
Keyword(s):  
Plasma Membrane ◽  
Rat Brain ◽  
Calcium Atpase ◽  
Synaptic Plasma Membrane ◽  
Plasma Membrane Calcium Atpase

scholarly journals Role of plasma membrane calcium ATPase 2 in spinal cord pathology

2010 ◽  
Vol 1 (5) ◽  
pp. 103 ◽  
Author(s):  
Amanda Kathleen Fakira
Keyword(s):  
Spinal Cord ◽  
Plasma Membrane ◽  
Calcium Atpase ◽  
Plasma Membrane Calcium Atpase

scholarly journals P558The role of plasma membrane calcium ATPase 1 in angiogenesis

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S137-S137
Author(s):  
A Njegic ◽  
D Page ◽  
H Shiels ◽  
E J Cartwright
Keyword(s):  
Plasma Membrane ◽  
Calcium Atpase ◽  
Plasma Membrane Calcium Atpase

355 Plasma membrane calcium ATPase isoform 4 as a potential drug target for treatment during hypertrophy

2007 ◽  
Vol 6 (1) ◽  
pp. 81-81
Author(s):  
E CARTWRIGHT ◽  
F BAUDOIN ◽  
D OCEANDY ◽  
S PREHAR ◽  
M ZI ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Drug Target ◽  
Calcium Atpase ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Plasma Membrane Calcium Atpase

Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-atpase

Life Sciences ◽  
1999 ◽  
Vol 64 (14) ◽  
pp. 179-183 ◽  
Author(s):  
J-L. Horn ◽  
P.K. Janicki ◽  
J.J. Franks
Keyword(s):  
Plasma Membrane ◽  
Rat Brain ◽  
Calcium Atpase ◽  
Synaptic Plasma Membrane ◽  
Plasma Membrane Calcium Atpase ◽  
Fluorinated Ether
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