scholarly journals Prevalence of lymphoid follicles in Helicobacter pylori associated gastritis.

1996 ◽  
Vol 49 (6) ◽  
pp. 527-527 ◽  
Author(s):  
M Rugge ◽  
M Cassaro ◽  
F Di Mario
Keyword(s):  
Helicobacter Pylori ◽  
Lymphoid Follicles

Lymphoid follicles in gastric mucosa of Helicobacter pylori infected patients regress after eradication treatment

1995 ◽  
Vol 108 (4) ◽  
pp. A55 ◽  
Author(s):  
G Battaglia ◽  
PE Lecis ◽  
PM Donisi ◽  
ME Benvenuti ◽  
G Leandro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Follicles

scholarly journals Involvement of Myeloid Dendritic Cells in the Development of Gastric Secondary Lymphoid Follicles in Helicobacter pylori-Infected Neonatally Thymectomized BALB/c Mice

2003 ◽  
Vol 71 (4) ◽  
pp. 2153-2162 ◽  
Author(s):  
Toshiki Nishi ◽  
Kazuichi Okazaki ◽  
Kimio Kawasaki ◽  
Toshiro Fukui ◽  
Hiroyuki Tamaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Helicobacter Pylori ◽  
Dendritic Cells ◽  
Epithelial Cells ◽  
Lamina Propria ◽  
Myeloid Dendritic Cells ◽  
Lymphoid Follicles ◽  
Inflammatory Protein ◽  
H Pylori ◽  
Antigen Presenting

ABSTRACT We previously described an animal model of Helicobacter pylori-induced follicular gastritis in neonatally thymectomized (nTx) mice. However, it is still not clear whether antigen-presenting dendritic cells (DCs) in the stomach have a role in the development of secondary follicles in H. pylori-infected nTx mice. We investigated the distribution of DC subsets using this model and examined their roles. To identify lymphoid and myeloid DCs, sections were stained with anti-CD11c (pan-DC marker) in combination with anti-CD8α (lymphoid DC marker) or anti-CD11b (myeloid DC marker) and were examined with a confocal microscope. Expression of macrophage inflammatory protein 3α (MIP-3α), which chemoattracts immature DCs, was analyzed by real-time PCR and immunohistochemistry. Follicular dendritic cells (FDCs) were stained with anti-SKY28 antibodies. In noninfected nTx mice, a few myeloid and lymphoid DCs were observed in the bottom portion of the lamina propria, whereas in H. pylori-infected nTx mice, there was an increased influx of myeloid DCs throughout the lamina propria. FDC staining was also observed in the stomachs of members of the infected group. MIP-3α gene expression was upregulated in the infected nTx group, and the immunohistochemistry analysis revealed MIP-3α-positive epithelial cells. These data suggest that H. pylori infection upregulates MIP-3α gene expression in gastric epithelial cells and induces an influx of myeloid DCs in the lamina propria of the gastric mucosa in nTx mice. Myeloid DCs and FDCs might contribute to the development of gastric secondary lymphoid follicles in H. pylori-infected nTx mice.

scholarly journals DC-LAMP+Dendritic Cells Are Recruited to Gastric Lymphoid Follicles in Helicobacter pylori-Infected Individuals

2013 ◽  
Vol 81 (10) ◽  
pp. 3684-3692 ◽  
Author(s):  
Malin Hansson ◽  
Malin Sundquist ◽  
Susanne Hering ◽  
B. Samuel Lundin ◽  
Michael Hermansson ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Dendritic Cells ◽  
Gastric Mucosa ◽  
Human Gastric Mucosa ◽  
Lymphoid Follicles ◽  
Content Type ◽  
Ulcer Disease ◽  
Hla Dr ◽  
H Pylori ◽  
Antigen Presenting

ABSTRACTInfection withHelicobacter pyloriis associated with development of ulcer disease and gastrointestinal adenocarcinoma. The infection leads to a large infiltration of immune cells and the formation of organized lymphoid follicles in the human gastric mucosa. Still, the immune system fails to eradicate the bacteria, and the substantial regulatory T cell (Treg) response elicited is probably a major factor permitting bacterial persistence. Dendritic cells (DCs) are professional antigen-presenting cells that can activate naive T cells, and maturation of DCs is crucial for the initiation of primary immune responses. The aim of this study was to investigate the presence and localization of mature human DCs inH. pylori-infected gastric mucosa. Gastric antral biopsy specimens were collected from patients withH. pylori-associated gastritis and healthy volunteers, and antrum tissue was collected from patients undergoing gastric resection. Immunohistochemistry and flow cytometry showed that DCs expressing the maturation marker dendritic cell lysosome-associated membrane glycoprotein (DC-LAMP; CD208) are enriched in theH. pylori-infected gastric mucosa and that these DCs are specifically localized within or close to lymphoid follicles. Gastric DC-LAMP-positive (DC-LAMP+) DCs express CD11c and high levels of HLA-DR but little CD80, CD83, and CD86. Furthermore, immunofluorescence analyses demonstrated that DC-LAMP+DCs are in the same location as FoxP3-positive putative Tregs in the follicles. In conclusion, we show that DC-LAMP+DCs with low costimulatory capacity accumulate in the lymphoid follicles in humanH. pylori-infected gastric tissue, and our results suggest that Treg-DC interactions may promote chronic infection by rendering gastric DCs tolerogenic.

scholarly journals Lymphoid follicles in children with Helicobacter pylori-negative gastritis

2017 ◽  
Vol Volume 10 ◽  
pp. 195-201 ◽  
Author(s):  
Efrat Broide ◽  
Vered Richter ◽  
Sonia Mendlovic ◽  
Tzippora Shalem ◽  
Adi Eindor-Abarbanel ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Lymphoid Follicles

Natural Progression of Helicobacter pylori-Negative Gastritis with Lymphoid Follicles in Children: Prospective Evaluation and Outcome

2021 ◽  
Vol 32 (7) ◽  
pp. 575-580
Author(s):  
Vered Richter ◽  
◽  
Sonia Mendlovic ◽  
Tzipi Shalem ◽  
Adi Eindor-Abarbanel ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Prospective Evaluation ◽  
Lymphoid Follicles ◽  
Natural Progression

scholarly journals The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori-Positive Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Celal Ulasoglu ◽  
Hatice Esin Temiz ◽  
Zuhal Aydan Sağlam
Keyword(s):  
Helicobacter Pylori ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Inclusion Criteria ◽  
Lymphoid Follicles ◽  
Cytotoxin Associated Gene A ◽  
B12 Deficiency ◽  
Vitamin Level ◽  
H Pylori

Background and Aim. As a worldwide infectious bacterium, H. pylori leads to stomach pathologies such as gastritis, peptic ulcer, gastric cancer, MALToma, and various extragastric manifestations. In our study, we aimed to investigate the association between serum vitamin B12 level and cytotoxin-associated gene-A (CagA) seropositivity, which is one of the virulence factors of Helicobacter pylori (H. pylori). Method. This study has been conducted on 289 patients who have met the inclusion criteria. Within these patients, 213 of them were H. pylori positive and 76 were negative. Vitamin B12 and CagA-IgG levels were assessed in consecutive dyspeptic patients undergoing upper endoscopy. Results. Out of 289 patients, 51.9% were women (n = 150) and H. pylori was detected in 213 (73.7%) patients. Histopathological evaluation with modified Sydney classification revealed lymphocyte infiltration in 66.8% (n = 193), activation in 46% (n = 133), metaplasia in 11.4% (n = 33), atrophy in 11.4% (n = 33), and lymphoid follicles in 21.1% (n = 61) of the patients. Within H. pylori-positive patients, the ratio of CagA positivity was 57.3% (n = 122). Low B12 vitamin level was significantly correlated with existence of H. pylori (p=0.02), CagA (p=0.002), lymphocyte (p=0.006), metaplasia (p=0.001), atrophy (p=0.001), and lymphoid follicles (p=0.006). Positivity of CagA has been detected to be statistically corelated with lymphocyte (p=0.001) and activation (p=0.005); however, the same relation was not present with atrophy (p=0.236). Conclusion. In conclusion, B12 deficiency was positively correlated with CagA positivity and gastric inflammatory activity.

scholarly journals Can histopathology of gastric tissue resected in sleeve gastrectomy be informative about serum iron levels?

2021 ◽  
Vol 38 (3) ◽  
pp. 318-321
Author(s):  
Yasemen ADALI ◽  
Özge ERTENER ◽  
Hatice BEŞEREN ◽  
Kenan BİNNETOĞLU
Keyword(s):  
Helicobacter Pylori ◽  
Sleeve Gastrectomy ◽  
Iron Deficiency ◽  
Intestinal Metaplasia ◽  
Serum Iron ◽  
Gastric Tissue ◽  
Lymphoid Follicles ◽  
Histopathological Findings ◽  
The Relationship ◽  
Lymphoid Aggregates

One of the most common post-operative deficiencies after bariatric surgery is iron deficiency and one of the important determinants of post-operative iron deficiency is the preoperative condition. In this study, it was aimed to investigate the relationship between iron levels and histopathological findings observed in gastric tissue resected in sleeve gastrectomy. Preoperative and postoperative iron levels were compared with the presence of inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, lymphoid follicles, and lymphoid aggregates observed in patients operated due to morbid obesity. The postoperative serum iron levels and preoperative values were compared and a statistically significant increase was found due to the use of iron-containing preparations after the operation. Among the parameters evaluated, inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, and the presence of lymphoid follicles were not found to be associated with iron levels, but it was noted that the presence of lymphoid aggregate in all cases and male cases was correlated with preoperative low iron levels (p values 0.047 and 0.015 respectively). In this study, which investigated the role of histopathological findings in the prediction of iron deficiency in sleeve gastrectomies, the relationship between preoperative iron levels, which was reported to be predictive for post-operative iron deficiency, and the presence of lymphoid aggregates was revealed. It is thought that other histopathological findings such as the presence of lymphoid follicle and Helicobacter pylori are also important in terms of iron levels but could not be revealed due to the limitations of the study.

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