Can histopathology of gastric tissue resected in sleeve gastrectomy be informative about serum iron levels?

One of the most common post-operative deficiencies after bariatric surgery is iron deficiency and one of the important determinants of post-operative iron deficiency is the preoperative condition. In this study, it was aimed to investigate the relationship between iron levels and histopathological findings observed in gastric tissue resected in sleeve gastrectomy. Preoperative and postoperative iron levels were compared with the presence of inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, lymphoid follicles, and lymphoid aggregates observed in patients operated due to morbid obesity. The postoperative serum iron levels and preoperative values were compared and a statistically significant increase was found due to the use of iron-containing preparations after the operation. Among the parameters evaluated, inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, and the presence of lymphoid follicles were not found to be associated with iron levels, but it was noted that the presence of lymphoid aggregate in all cases and male cases was correlated with preoperative low iron levels (p values 0.047 and 0.015 respectively). In this study, which investigated the role of histopathological findings in the prediction of iron deficiency in sleeve gastrectomies, the relationship between preoperative iron levels, which was reported to be predictive for post-operative iron deficiency, and the presence of lymphoid aggregates was revealed. It is thought that other histopathological findings such as the presence of lymphoid follicle and Helicobacter pylori are also important in terms of iron levels but could not be revealed due to the limitations of the study.

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Histopathological Findings in Laparoscopic Sleeve Gastrectomy Specimens from Patients with Obesity in Saudi Arabia

Gastroenterology Research and Practice ◽

10.1155/2018/1702705 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

Khaldoon Aljerian

Keyword(s):

Morbid Obesity ◽

Helicobacter Pylori ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Patient Population ◽

University Hospital ◽

Histopathological Changes ◽

Single Center ◽

Histopathological Findings ◽

Bariatric Surgical Procedure

Laparoscopic sleeve gastrectomy is a bariatric surgical procedure performed in patients with morbid obesity that provides the opportunity to review histopathological changes. The aim of this study was to characterize resected gastric specimens obtained from a Saudi patient population at a single center for a prospectively maintained database of laparoscopic sleeve gastrectomy cases. The histopathological findings from all patients undergoing laparoscopic sleeve gastrectomies at King Khalid University Hospital between 2010 and 2015 were retrospectively reviewed. Of the 602 cases reviewed, the majority (83.4% [n=502]) exhibited chronic gastritis, whereas 22.3% (n=134) involved Helicobacter pylori infections with active gastritis, 1% (n=6) had intestinal metaplasia, and one case (0.17%) revealed gastric adenocarcinoma. As the findings revealed conditions that are treatable, I highly recommend histological examinations of all sleeve gastrectomy specimens from a Saudi patient population.

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Lactoferrin Levels in the Gastric Tissue ofHelicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia

Mediators of Inflammation ◽

10.1155/2012/214581 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Yaşar Doğan ◽

Tülay Erkan ◽

Zerrin Önal ◽

Merve Usta ◽

Gülen Doğusoy ◽

...

Keyword(s):

Helicobacter Pylori ◽

Abdominal Pain ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Ferritin Level ◽

Deficiency Anemia ◽

Antral Mucosa ◽

Gastric Tissue ◽

Negative Controls

Aim. To determine gastric tissue lactoferrin (Lf) levels ofHelicobacter pylori-(Hp-) positive and -negative patients and its effect on anemia.Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups.Results. The study included 64 cases (average: years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were % and , respectively. Hp-negative cases showed significantly different values of % and , respectively. Hemoglobin and serum ferritin values of Hp-positive cases were /dL and /mL, but these were comparable with Hp-negative cases (/dL and /mL).Conclusions.Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.

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Prevalence of H. pylori Infection in Relatives of Peruvian Patients with Gastric Cancer

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2021.6.1.53-57 ◽

2021 ◽

Vol 6 (1) ◽

pp. 53-57

Author(s):

Miluska Castillo ◽

Luis A. Bernabe ◽

Carlos A. Castaneda ◽

Nancy Suarez ◽

Fernando Barreda ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Tissue Sample ◽

Gastric Tissue ◽

Infection Rates ◽

Urease Test ◽

H Pylori ◽

The Relationship

Objective: The aim of this study was to determine the relationship between Helicobacter pylori (H. pylori) infection in relatives and patients with gastric cancer (GC).Methods: H. pylori infection was evaluated by the breath urease test in 171 relatives and by qPCR technique in gastric tissue of 61 patients (n=45 for GC and n=16 for non-GC). Results: There were included 137 relatives of GC patients and 34 of non-GC. The median age of the relatives of patients with a gastric tissue sample was 39 years (10-86). Infection was found in 60.2% (n=103) relatives. There were no higher H. pylori infection rates in relatives of patients with gastric cancer (62% vs 62.9%, p=0.33), H. pylori infection (60% vs 60%, p=0.96), or metaplasia (58.8% vs 61.8%, p=0.71). Conclusion: The prevalence of infection in relatives of GC patients is high in our population but not associated with H. pylori presence in the paired case.

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A Review of Sleeve Gastrectomy Specimen Histopathology

The American Surgeon ◽

10.1177/000313481608201126 ◽

2016 ◽

Vol 82 (11) ◽

pp. 1101-1104 ◽

Cited By ~ 10

Author(s):

Luke A. Kinsinger ◽

James C. Garber ◽

Oliver Whipple

Keyword(s):

Sleeve Gastrectomy ◽

Intestinal Metaplasia ◽

Retrospective Review ◽

Gastrointestinal Stromal Tumors ◽

Mitotic Rate ◽

Single Institution ◽

Stromal Tumors ◽

Increased Risk ◽

Risk Of Malignancy ◽

Lymphoid Aggregates

With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution. Of the specimens, 122 had no significant histopathology, 91 had gastritis, 13 had lymphoid aggregates, 5 had hyperplasia, 3 had intestinal metaplasia, 3 had gastrointestinal stromal tumors (GISTs), and 3 had gastric polyps. Of the GISTs all had a low mitotic rate and the size of the tumor ranged from 1.5 to 4.5 cm. The findings of metaplasia may be a marker for increased risk of malignancy and may require additional surveillance. The findings of GIST may warrant interval imaging to survey for recurrence, though the likelihood of recurrence for the tumors in this study is less than 2 per cent based on previous studies.

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The Immunohistochemistry Profile of Lymphocytic Gastritis in Celiac Disease and Helicobacter Pylori Infection: Interplay between Infection and Inflammation

Mediators of Inflammation ◽

10.1155/2007/81838 ◽

2007 ◽

Vol 2007 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Efrat Broide ◽

Judith Sandbank ◽

Eitan Scapa ◽

Nimrod Alain Kimchi ◽

Michael Shapiro ◽

...

Keyword(s):

Helicobacter Pylori ◽

Celiac Disease ◽

Immunohistochemical Staining ◽

Intraepithelial Lymphocytes ◽

Upper Endoscopy ◽

Number Density ◽

Lymphocytic Gastritis ◽

Infection And Inflammation ◽

The Relationship ◽

Lymphoid Aggregates

Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac disease (CD). We aimed to clarify the relationship between Hp infection and CD by defining a unique histopathology profile of LG in these two diseases. Forty patients who underwent upper endoscopy were divided into four groups: eight controls, ten active CD patients without Hp, twelve CD negative with Hp, and ten active CD with Hp infection. Antral samples were assessed by immunohistochemical staining for CD20, CD3, CD4, CD8, CD57, CNA42, and Ki67 for lymphoid aggregates, intraepithelial lymphocytes (IELs) number, density of lamina propria (LP) lymphocytes, and inflammatory glandular involvement. Only IELs positive for CD3 and CD8 were increased significantly in CD patients with or without Hp infection. Hp did not contribute to the number of CD8 IELs. In complicated cases with Hp and suspicious for CD, the number of CD8+ IELs hints toward a CD rather than Hp infection.

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Tu1341 - Histopathological Findings and Helicobacter Pylori Infection in Sleeve Gastrectomy

Gastroenterology ◽

10.1016/s0016-5085(18)34400-7 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-1344

Author(s):

Maira Xavier ◽

Joao Batista Souza ◽

Reynaldo Quinino ◽

Andre Barbosa ◽

Igor Pinto ◽

...

Keyword(s):

Helicobacter Pylori ◽

Sleeve Gastrectomy ◽

Helicobacter Pylori Infection ◽

Histopathological Findings

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Burden of Helicobacter pylori Infections and Associated Risk Factors among Cases of Iron Deficiency Anaemia in Egypt

Microbiology Research Journal International ◽

10.9734/mrji/2020/v30i730241 ◽

2020 ◽

pp. 80-91

Author(s):

Hadir M. El- Kady ◽

Waiel Al- Kahiry ◽

Hadeel Said Tawfik Abdelsalam

Keyword(s):

Helicobacter Pylori ◽

Iron Deficiency ◽

Serum Iron ◽

Iron Deficiency Anaemia ◽

Binding Capacity ◽

Public Health Problem ◽

Occult Blood ◽

Cross Sectional ◽

Deficiency Anaemia ◽

H Pylori

Introduction: Iron deficiency anaemia (IDA) is a worldwide nutritional problem; it accounts for about half of the world’s anaemia burden. Globally, Helicobacter pylori (H. pylori) is becoming an increasingly troublesome economic and public health problem. The colonization of the organism in gastric mucosa may impair iron uptake and increase iron loss, potentially leading to iron deficiency anaemia. The mechanisms by which H. pylori is postulated to cause IDA are H. pylori -associated chronic gastritis resulting in hypo/or achlorhydria, reduced ascorbic acid secretion and reduced intestinal iron absorption, occult blood loss due to chronic erosive gastritis, and sequestration and utilization of iron by Helicobacter pylori. Aims: To detect H. pylori–related IDA prevalence among asymptomatic cases of anaemia and to address the possibility that such infection may play a detrimental role in their blood picture, serum iron and ferritin levels and total iron binding capacity (TIBC) Study Design & Methods: Facility based cross-sectional study was conducted in the period from December 2018 to May 2019. Screening was done for asymptomatic attendants of a number of private laboratories in Beheira, Alexandria and Gharbiya governorates. Three hundreds of whom were proved to be cases of IDA and were further tested for H. pylori antigen in stool. Results: Helicobacter pylori Ag test in stool was positive in 180 out of 300 cases of iron deficiency anaemia. The infection significantly affected the haemoglobin level, MCV, MCH and RDW in studied cases (p<0.05). Infection with H. pylori also significantly affected the serum iron, serum ferritin and TIBC in the studied cases of IDA (p<0.05). Conclusion: A significant association between H. pylori infection and IDA. Screening for H. pylori among unexplained cases of IDA is recommended.

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A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

10.36106/ijsr/6820602 ◽

2020 ◽

pp. 1-3

Author(s):

Lakshmi M ◽

Sumapriya M ◽

Channamsetty Anusha

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Febrile Seizure ◽

Serum Iron ◽

Febrile Convulsion ◽

Febrile Seizures ◽

Deficiency Anemia ◽

Age Group ◽

Febrile Convulsions ◽

The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

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Hubungan Kadar Komponen Besi Darah Pendonor terhadap Kualitas Packed Red Cells (PRC) di UDD PMI Provinsi Sumatera Selatan

Jurnal Surya Medika ◽

10.33084/jsm.v7i1.2303 ◽

2021 ◽

Vol 7 (1) ◽

pp. 66-71

Author(s):

Rahmi Widiyawati ◽

Zen Hafy ◽

Phey Liana

Keyword(s):

Iron Deficiency ◽

Serum Iron ◽

Transferrin Saturation ◽

Red Cells ◽

Component Level ◽

Cross Sectional ◽

Second Stage ◽

Cross Sectional Design ◽

The Relationship

Iron is the essential component of our body especially used to make Hemoglobin. If the intake of iron enters from our food less than issued, it makes our reserve iron will be used, and it can cause iron deficiency. There are three pathogenesis stages of iron deficiency, first marked by reduced iron reserve or the absence of iron reserved, ferritin levels decreased, while other parameters to determinate the presence of iron deficiency( Serum Iron, TIBC, Hb, Transferrin Saturation) are still normal. The purpose of this study was to analyze the relationship level of donor iron components and quality of Packed Red Cells (PRC) in UDD PMI Provinsi Sumatera Selatan. This research is an analytic observational study with a cross-sectional design. The result of the research was conducted in April 2021, using 86 blood samples from donors. It showed there were 15 samples with iron deficiency. Consisted of 9 samples with iron deficiency in the first stage and 6 samples in the second stage. It is known that there are 6 samples with poor PRC quality; all of them are iron deficiency in the second stage. In conclusion, there is a significant relationship iron component level of the donor and the quality of PRC p<0,05.

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