Natural Progression of Helicobacter pylori-Negative Gastritis with Lymphoid Follicles in Children: Prospective Evaluation and Outcome

2021 ◽  
Vol 32 (7) ◽  
pp. 575-580
Author(s):  
Vered Richter ◽  
◽  
Sonia Mendlovic ◽  
Tzipi Shalem ◽  
Adi Eindor-Abarbanel ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Prospective Evaluation ◽  
Lymphoid Follicles ◽  
Natural Progression

Lymphoid follicles in gastric mucosa of Helicobacter pylori infected patients regress after eradication treatment

1995 ◽  
Vol 108 (4) ◽  
pp. A55 ◽  
Author(s):  
G Battaglia ◽  
PE Lecis ◽  
PM Donisi ◽  
ME Benvenuti ◽  
G Leandro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Lymphoid Follicles

scholarly journals Prevalence of lymphoid follicles in Helicobacter pylori associated gastritis.

1996 ◽  
Vol 49 (6) ◽  
pp. 527-527 ◽  
Author(s):  
M Rugge ◽  
M Cassaro ◽  
F Di Mario
Keyword(s):  
Helicobacter Pylori ◽  
Lymphoid Follicles

scholarly journals Involvement of Myeloid Dendritic Cells in the Development of Gastric Secondary Lymphoid Follicles in Helicobacter pylori-Infected Neonatally Thymectomized BALB/c Mice

2003 ◽  
Vol 71 (4) ◽  
pp. 2153-2162 ◽  
Author(s):  
Toshiki Nishi ◽  
Kazuichi Okazaki ◽  
Kimio Kawasaki ◽  
Toshiro Fukui ◽  
Hiroyuki Tamaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Helicobacter Pylori ◽  
Dendritic Cells ◽  
Epithelial Cells ◽  
Lamina Propria ◽  
Myeloid Dendritic Cells ◽  
Lymphoid Follicles ◽  
Inflammatory Protein ◽  
H Pylori ◽  
Antigen Presenting

ABSTRACT We previously described an animal model of Helicobacter pylori-induced follicular gastritis in neonatally thymectomized (nTx) mice. However, it is still not clear whether antigen-presenting dendritic cells (DCs) in the stomach have a role in the development of secondary follicles in H. pylori-infected nTx mice. We investigated the distribution of DC subsets using this model and examined their roles. To identify lymphoid and myeloid DCs, sections were stained with anti-CD11c (pan-DC marker) in combination with anti-CD8α (lymphoid DC marker) or anti-CD11b (myeloid DC marker) and were examined with a confocal microscope. Expression of macrophage inflammatory protein 3α (MIP-3α), which chemoattracts immature DCs, was analyzed by real-time PCR and immunohistochemistry. Follicular dendritic cells (FDCs) were stained with anti-SKY28 antibodies. In noninfected nTx mice, a few myeloid and lymphoid DCs were observed in the bottom portion of the lamina propria, whereas in H. pylori-infected nTx mice, there was an increased influx of myeloid DCs throughout the lamina propria. FDC staining was also observed in the stomachs of members of the infected group. MIP-3α gene expression was upregulated in the infected nTx group, and the immunohistochemistry analysis revealed MIP-3α-positive epithelial cells. These data suggest that H. pylori infection upregulates MIP-3α gene expression in gastric epithelial cells and induces an influx of myeloid DCs in the lamina propria of the gastric mucosa in nTx mice. Myeloid DCs and FDCs might contribute to the development of gastric secondary lymphoid follicles in H. pylori-infected nTx mice.

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