Withdrawn: 595 A rapid progressive fatal case of heat stroke

The effects of heat stroke on hepatic structure were studied in 32 Bantu patients who worked underground in the Transvaal and Orange Free State Gold Mines.Judging from biochemical and morphologic findings, liver damage is an invariable complication of heat stroke. In the milder cases (90 per cent) raised enzyme levels, bromsulphalein retention, and increased prothrombin times were the most common abnormalities.

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Dengue hémorragique chez un patient traité au long cours par un antiagrégant plaquettaire À propos d'un cas mortel en MartiniqueDengue hemorrhagic fever in a patient administered long-term anti-platelet medication: one fatal case in Martinique

Réanimation Urgences ◽

10.1016/s1164-6756(98)90047-0 ◽

1998 ◽

Vol 7 (6) ◽

pp. 665-667

Author(s):

P Chesneau

Keyword(s):

Fatal Case ◽

Hemorrhagic Fever

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Heat Stroke

Scientific American ◽

10.1038/scientificamerican02161895-15955csupp ◽

1895 ◽

Vol 39 (998supp) ◽

pp. 15955-15955

Keyword(s):

Heat Stroke

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Immune mediated destruction of platelets in dogs with heat stroke: A prospective study

Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere ◽

10.1055/s-0038-1622811 ◽

2009 ◽

Vol 37 (05) ◽

pp. 314-318 ◽

Cited By ~ 1

Author(s):

L. Keller ◽

K. Meichner ◽

S. Unterer ◽

K. Hartmann ◽

I. Zenker

Keyword(s):

Heat Stroke ◽

Treatment Protocol ◽

Severe Thrombocytopenia ◽

Prospective Evaluation ◽

Antiplatelet Antibodies ◽

Time Period ◽

Immune Mediated ◽

Standardized Treatment ◽

A Prospective Study ◽

Risk For Bleeding

Summary Objective: Severe thrombocytopenia is a common sequelae to heat stroke in dogs. So far it has been hypothezised that it is due to disseminated intravascular coagulation. We hypothezised that it is due to immune mediated destruction via antiplatelet antibodies. Material and methods: Prospective evaluation of dogs with heat stroke from May 2005 to August 2008. Dogs that developed severe thrombocytopenia within 5 days of admission were included in the study. All dogs were treated with a standardized treatment protocol. In addition, they received either immunoglobulins or prednisolone. Results: Six dogs were presented with heat stroke during that time period. Four developed a severe thrombocytopenia. All four dogs tested positive for antiplatelet antibodies and did not have elevated D-Dimers at that time. Platelet count in three dogs recovered fully, one dog was euthanized due to liver and renal failure. Conclusion: In those cases thrombocytopenia was due to immune mediated destruction not due to DIC. Clinical rele-vance: Due to the severity of the thrombocytopenia and the high risk for bleeding in those patients, immunosuppressive therapy in addition to DIC prophylaxis should be discussed.

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