Screening for colorectal cancer by faecal occult blood test: comparison of immunochemical tests

2000 ◽  
Vol 7 (1) ◽  
pp. 35-37 ◽  
Author(s):  
G. Castiglione ◽  
M. Zappa ◽  
G. Grazzini ◽  
T. Rubeca ◽  
P. Turco ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Population Based ◽  
Latex Agglutination ◽  
Faecal Occult Blood ◽  
Faecal Occult ◽  
Diagnostic Work ◽  
Work Up

Objective To compare two immunochemical faecal occult blood tests based on reversed passive haemagglutination (RPHA) or latex agglutination (Hdia) in a population based screening setting. Method Hdia was interpreted according to three positivity thresholds: 100, 150, or 200 ng of haemoglobin/mg of specimen solution. A total of 5844 subjects were recruited into the study, from 17 432 invited subjects aged 50–70. Results Positivity rates were 3.3% for RPHA, Hdia100 3.5%, Hdia150 2.5%, Hdia200 2.0%. Among subjects complying with the diagnostic work up, colorectal cancer (CRC) was detected in 19 subjects (17 RPHA positive, 16 Hdia100 positive, 15 Hdia150 positive, 14 Hdia200 positive) and high risk adenoma/s in 41 subjects (28 RPHA positive, 32 Hdia100 positive, 29 Hdia150 positive, 25 Hdia200 positive). The prevalence of screen positive CRC in the population was for RPHA 2.9‰, Hdia100 2.7‰, Hdia150 2.6‰, Hdia200 2.4‰. The prevalence of screen positive high risk adenomas in the population was for RPHA 4.8‰, Hdia100 5.5‰, Hdia150 5.0‰, Hdia200 4.3‰. Conclusion Hdia100 was as sensitive as RPHA for cancer and high risk adenomas. As Hdia is less technically complex than RPHA, it is a valid alternative to the latter, provided that full automation of the development procedure is available. Increasing the positivity threshold of Hdia up to 150 or 200 ng of haemoglobin/mg of specimen solution is not advisable as the increase in specificity is too small to justify the corresponding decrease in the detection of screen positive cancers in the population.

scholarly journals Screening for colorectal cancer in defunctioned colons

2018 ◽  
Vol 25 (4) ◽  
pp. 178-182
Author(s):  
Fayyaz Akbar ◽  
Aaron Quyn ◽  
Robert Steele
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Cancer Screening ◽  
Online Survey ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Population Based ◽  
Time Interval ◽  
Faecal Occult Blood ◽  
Faecal Occult

Objectives Population-based colorectal (bowel) cancer screening using faecal occult blood tests leads to a reduction in cause-specific mortality. However, in people where the colon is defunctioned, the use of standard faecal occult blood test is not appropriate. The aim of this study was to examine the current trends of clinical practice for colorectal cancer screening in people with defunctioned colons. Methods An online survey was performed using SurveyMonkey. All members of the Association of Coloproctology of Great Britain and Ireland were invited by email to participate. Reminders were sent to non-responders and partial responders till six weeks. All responses were included in our analysis. Results Of the 206 (34.59%) questionnaires completed, all questions were answered in 110 (55.8%). Among responders, 94 (85.4%) were colorectal consultant surgeons, 72% had worked in their current capacity for more than five years, and 105 (50.9%) had encountered colorectal cancer in defunctioned colons during their career. Some 72.2% of responders stated that a screening test for colorectal cancer in patients with defunctioned colons was currently not offered, or that they did not know whether or not it was offered in their area. Conclusions Bowel screening in the United Kingdom is currently not offered to 72.2% of the age appropriate population with defunctioned colons. Among responding colorectal surgeons, 50% had encountered colorectal cancer in such patients. There is considerable variability in clinical practice regarding the optimal age for onset of screening, time interval, and the optimal modality to offer for screening in such cases.

The effects of population-based faecal occult blood test screening upon emergency colorectal cancer admissions in Coventry and north Warwickshire

Gut ◽  
2007 ◽  
Vol 57 (2) ◽  
pp. 218-222 ◽  
Author(s):  
S J Goodyear ◽  
E Leung ◽  
A Menon ◽  
S Pedamallu ◽  
N Williams ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Blood Test ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Population Based ◽  
Occult Blood Test ◽  
Faecal Occult Blood ◽  
Faecal Occult

scholarly journals Exploring the Barriers Toward Colorectal Cancer Screening: A Literature Review

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Rolla Hamdan ◽  
Jessie Johnson ◽  
Maryam Fatemi ◽  
Kathleen Benjamin ◽  
Afrah Moosa
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Blood Test ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Occult Blood Test ◽  
Faecal Occult Blood ◽  
Primary Health ◽  
Faecal Occult ◽  
Bowel Cancer Screening

Background: Colorectal cancer is the third most common cancer and the second leading cause of death worldwide. Bowel cancer screening helps prevent colon cancer by early detection of polyps, leading to efficient treatment and reduced mortality. Within Qatar, primary health facilities promote bowel screening by using the faecal occult blood test. However, the popularity and use of this test is still low. Aim: The aim of this literature review is to explore barriers related to colorectal cancer bowel screening using the faecal occult blood test in primary health care settings to facilitate colorectal cancer screening in Qatar. Method: Cronin’s five step framework for literature reviews was utilized for this paper. This review included nine articles that were peer-reviewed and published between 2009 and 2019. The nine articles were appraised by using the Mixed Methods Appraisal Tool. This tool has separate criteria to assess the quality of the qualitative, quantitative, and mixed-method studies. Result: Three main barriers to bowel cancer screening included knowledge deficit, personal beliefs and organizational barriers. Conclusion: The main barriers are related to the patients’ lack of knowledge and personal beliefs. Overcoming these barriers is essential to raising awareness about this issue among all nurses, physicians, and patients. It is necessary to involve stakeholders in order to mitigate barriers. Developing educational activities for healthcare professionals will provide information that they can share with patients to encourage screening and decrease the fear of the test. Developing a pamphlet to increase patient awareness will also encourage screening and work toward decreasing fear. Key words: faecal occult blood test, faecal immunochemical test, barriers

scholarly journals Adding familial risk assessment to faecal occult blood test can increase the effectiveness of population-based colorectal cancer screening

2011 ◽  
Vol 47 (10) ◽  
pp. 1571-1577 ◽  
Author(s):  
N. Dekker ◽  
L.G.M. van Rossum ◽  
M. Van Vugt-van Pinxteren ◽  
S.H.C. van Stiphout ◽  
R.P.M.G. Hermens ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Assessment ◽  
Cancer Screening ◽  
Blood Test ◽  
Familial Risk ◽  
Occult Blood ◽  
Faecal Occult Blood Test ◽  
Population Based ◽  
Occult Blood Test ◽  
Faecal Occult
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