Second trimester screening for Down's syndrome: 7 years experience

2001 ◽  
Vol 8 (3) ◽  
pp. 128-131 ◽  
Author(s):  
J.M. Beaman ◽  
D.J. Goldie
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Second trimester screening for Down's syndrome using maternal serum dimeric inhibin A

1996 ◽  
Vol 44 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Euan M. Wallace ◽  
Ian A. Swanston ◽  
Alan S. McNeilly ◽  
J. Peter Ashby ◽  
Gillian Blundell ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Second Trimester ◽  
Inhibin A ◽  
Second Trimester Screening ◽  
Trimester Screening

scholarly journals First-Trimester or Second-Trimester Screening, or Both, for Down's Syndrome

2005 ◽  
Vol 353 (19) ◽  
pp. 2001-2011 ◽  
Author(s):  
Fergal D. Malone ◽  
Jacob A. Canick ◽  
Robert H. Ball ◽  
David A. Nyberg ◽  
Christine H. Comstock ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Women's opinions and the implications of first- versus second-trimester screening for fetal Down's syndrome

1997 ◽  
Vol 17 (11) ◽  
pp. 1011-1018 ◽  
Author(s):  
L. H. Kornman ◽  
M. J. M. Wortelboer ◽  
J. R. Beekhuis ◽  
L. P. Morssink ◽  
A. Mantingh
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
Trimester Screening

Importance of the integrated test in the Down’s syndrome screening algorithm

2018 ◽  
Vol 25 (3) ◽  
pp. 114-118
Author(s):  
Drahomira Springer ◽  
Jaroslav Loucky ◽  
Pavel Tesner ◽  
David Cutka ◽  
David Stejskal ◽  
...  
Keyword(s):  
Screening Program ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Sequential Test ◽  
Congenital Defects ◽  
Antenatal Screening ◽  
Second Trimester ◽  
Second Trimester Screening ◽  
The Impact

Objective In the Czech Republic, over 97% of all pregnant women undergo some type of antenatal screening for Down’s syndrome. In about 95% of cases with a confirmed fetal chromosomal abnormality, the pregnancy is terminated. The most commonly used test is the first trimester combined test. We investigated the impact of implementing an integrated sequential test to improve the detection of Down’s syndrome pregnancies. Methods Data on the incidence of congenital defects, number of births, and affected pregnancies terminated are recorded in the National Registry of Congenital Anomalies. Anonymous data on cases of Down’s syndrome diagnosed antenatally or postnatally between 2010 and 2015 in one of the large antenatal care centers were analyzed. Results There were 600 diagnoses of Down’s syndrome (5.7 per 1000 births), 90% of which were made antenatally. Of antenatally detected cases, 80% were indicated for diagnostic procedure by multimarker screening results. In the multimarker screen positive group, 75% cases were first trimester positive and 25% second trimester positive (most of these had positive integrated test results). Among Down’s syndrome cases indicated for antenatal diagnosis by multimarker screening results 6.25% (n = 26) were first trimester negative, and became positive after integration with the second trimester screening results. Conclusions Results from five major Czech antenatal centers confirm that an integrated sequential test would detect 80–85% of Down’s syndrome fetuses in the first trimester and at least an extra 5–10% of Down’s syndrome pregnancies in the second trimester of pregnancy. These are important data that should be considered in implementing the national antenatal screening program.

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