Experimental infection of slaughter pigs with classical swine fever virus: transmission of the virus, course of the disease and antibody response

1999 ◽  
Vol 145 (9) ◽  
pp. 243-248 ◽  
Author(s):  
H. Laevens ◽  
F. Koenen ◽  
H. Deluyker ◽  
A. de Kruif
Keyword(s):  
Antibody Response ◽  
Experimental Infection ◽  
Classical Swine Fever Virus ◽  
Virus Transmission ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Slaughter Pigs

scholarly journals An experimental infection with a classical swine fever virus in weaner pigs

1998 ◽  
Vol 20 (2) ◽  
pp. 46-49 ◽  
Author(s):  
H. Laevens ◽  
H. Deluyker ◽  
F. Koenen ◽  
G. Van Caenegem ◽  
J.P. Vermeersch ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Weaner Pigs

scholarly journals Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus

Viruses ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 775 ◽  
Author(s):  
Miaomiao Wang ◽  
Enrica Sozzi ◽  
José Alejandro Bohórquez ◽  
Mònica Alberch ◽  
Joan Pujols ◽  
...  
Keyword(s):  
Antibody Response ◽  
Classical Swine Fever Virus ◽  
Animal Health ◽  
High Capacity ◽  
Classical Swine Fever ◽  
Neutralizing Antibody ◽  
Cross Reactivity ◽  
Fever Virus ◽  
Genotype 2 ◽  
Multiple Species

This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high capacity for virus trans-placental transmission as well as the birth of lambs suffering OVPV-persistent infection. The OVPV infection induced early antibody response detected by the specific ELISA against classical swine fever virus (CSFV), another important virus affecting swine. The neutralizing antibody response were similar against CSFV strains from genotype 2 and the OVPV. These viruses showed high identity in the B/C domain of the E2-glycoprotein. Close molecular diagnostics cross-reactivity between CSFV and OVPV was found and a new OVPV molecular assay was developed. The phylodynamic analysis showed that CSFV seems to have emerged as the result of an inter-species jump of Tunisian sheep virus (TSV) from sheep to pigs. The OVPV and the CSFV share the TSV as a common ancestor, emerging around 300 years ago. This suggests that the differentiation of TSV into two dangerous new viruses for animal health (CSFV and OVPV) was likely favored by human intervention for the close housing of multiple species for intensive livestock production.

scholarly journals Within- and between-pen transmission of Classical Swine Fever Virus: a new method to estimate the basic reproduction ratio from transmission experiments

2002 ◽  
Vol 128 (2) ◽  
pp. 293-299 ◽  
Author(s):  
D. KLINKENBERG ◽  
J. DE BREE ◽  
H. LAEVENS ◽  
M. C. M. DE JONG
Keyword(s):  
Confidence Intervals ◽  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Simultaneous Estimation ◽  
Published Data ◽  
Martingale Method ◽  
Basic Reproduction Ratio ◽  
Reproduction Ratio ◽  
Slaughter Pigs

We present a method to estimate basic reproduction ratio R0 from transmission experiments. By using previously published data of experiments with Classical Swine Fever Virus more extensively, we obtained smaller confidence intervals than the martingale method used in the original papers. Moreover, our method allows simultaneous estimation of a reproduction ratio within pens R0w and a modified reproduction ratio between pens R′0b. Resulting estimates of R0w and R′0b for weaner pigs were 100 (95% CI 54·4–186) and 7·77 (4·68–12·9), respectively. For slaughter pigs they were 15·5 (6·20–38·7) and 3·39 (1·54–7·45), respectively. We believe, because of the smaller confidence intervals we were able to obtain, that the method presented here is better suited for use in future experiments.

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