Interactions of U24 from Roseolovirus with WW domains: canonical vs noncanonical

2017 ◽  
Vol 95 (3) ◽  
pp. 350-358 ◽  
Author(s):  
Yurou Sang ◽  
Rui Zhang ◽  
A. Louise Creagh ◽  
Charles A. Haynes ◽  
Suzana K. Straus
Keyword(s):  
Terminal Segment ◽  
Titration Calorimetry ◽  
Regulatory Factor ◽  
Human Herpes ◽  
Ww Domain ◽  
Ww Domains ◽  
Human Herpes Virus ◽  
Domain Interactions ◽  
Py Motif ◽  
Human Herpes Virus Type

U24 is a C-terminal membrane-anchored protein found in both human herpes virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminal segment that is rich in prolines (PPxY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that U24 interacts strongly with Nedd4 WW domains, in particular, hNedd4L-WW3*. It was also shown that this interaction depends strongly on the nature of the amino acids that are upstream from the PY motif in U24. In this contribution, data was obtained from pull-downs, isothermal titration calorimetry, and NMR to further determine what modulates U24:WW domain interactions. Specifically, 3 non-canonical WW domains from human Smad ubiquitination regulatory factor (Smurf), namely hSmurf2-WW2, hSmurf2-WW3, and a tandem construct hSmurf2-WW2 + 3, were studied. Overall, the interactions between U24 and these Smurf WW domains were found to be weaker than those in U24:Nedd4 WW domain pairs, suggesting that U24 function is tightly linked to specific E3 ubiqitin ligases.

scholarly journals Viruses go modular

2020 ◽  
Vol 295 (14) ◽  
pp. 4604-4616 ◽  
Author(s):  
Ariel Shepley-McTaggart ◽  
Hao Fan ◽  
Marius Sudol ◽  
Ronald N. Harty
Keyword(s):  
Hippo Pathway ◽  
Host Proteins ◽  
Dna Viruses ◽  
Ww Domain ◽  
Ww Domains ◽  
Host Interactions ◽  
New Class ◽  
Domain Interactions ◽  
Molecular Aspects ◽  
The Hippo Pathway

The WW domain is a modular protein structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in specific target proteins. The compact modular nature of the WW domain makes it ideal for mediating interactions between proteins in complex networks and signaling pathways of the cell (e.g. the Hippo pathway). As a result, WW domains play key roles in a plethora of both normal and disease processes. Intriguingly, RNA and DNA viruses have evolved strategies to hijack cellular WW domain–containing proteins and thereby exploit the modular functions of these host proteins for various steps of the virus life cycle, including entry, replication, and egress. In this review, we summarize key findings in this rapidly expanding field, in which new virus-host interactions continue to be identified. Further unraveling of the molecular aspects of these crucial virus-host interactions will continue to enhance our fundamental understanding of the biology and pathogenesis of these viruses. We anticipate that additional insights into these interactions will help support strategies to develop a new class of small-molecule inhibitors of viral PPxY-host WW-domain interactions that could be used as antiviral therapeutics.

Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation

2016 ◽  
Vol 57 (11) ◽  
pp. 2555-2559 ◽  
Author(s):  
Frank Cirrone ◽  
Cindy Ippoliti ◽  
Hanhan Wang ◽  
Xi Kathy Zhou ◽  
Usama Gergis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Allogeneic Stem Cell Transplantation ◽  
Umbilical Cord Blood ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Early Human ◽  
Human Herpes Virus Type

scholarly journals Human Herpes Virus Type 6 Can Cause Skin Lesions at the BCG Inoculation Site Similar to Kawasaki Disease

2012 ◽  
Vol 228 (4) ◽  
pp. 351-353 ◽  
Author(s):  
Yosuke Kakisaka ◽  
Tomoichiro Ohara ◽  
Saori Katayama ◽  
Tasuku Suzuki ◽  
Shu Sasai ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Virus Type ◽  
Herpes Virus ◽  
Skin Lesions ◽  
Human Herpes ◽  
Inoculation Site ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

scholarly journals Primary infection with human herpes virus type 6, post-pediatric liver transplantation-A pathogen to remember

2018 ◽  
Vol 21 (1) ◽  
pp. e13014
Author(s):  
Adi Pappo-Toledano ◽  
Sara Dovrat ◽  
Zvia Soufiev ◽  
Yael Mozer-Glassberg ◽  
Irit Krause ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Virus Type ◽  
Primary Infection ◽  
Herpes Virus ◽  
Pediatric Liver Transplantation ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Pediatric Liver ◽  
Herpès Virus ◽  
Human Herpes Virus Type

scholarly journals Antiviral activity of Stachys Thracica Dav. extracts against Human Herpes virus type 1 and 2

Biodiscovery ◽  
2017 ◽  
Vol 20 ◽  
pp. e15022
Author(s):  
Petya Angelova ◽  
Venelin Tsvetkov ◽  
Anton Hinkov ◽  
Daniel Todorov ◽  
Kalina Shishkova ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Detection of human herpes virus type-6 in patients undergoing hemodialysis

2018 ◽  
Vol 13 (4) ◽  
pp. 237-243
Author(s):  
Naeme Javid ◽  
Alireza Mohebbi ◽  
Samira Eskandarian ◽  
Alireza Tahamtan ◽  
Fatemeh S Askari ◽  
...  
Keyword(s):  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Exposure to Human Herpes Virus Type 6 Protects Against Allergic Asthma in Mice

2010 ◽  
Vol 01 (01) ◽  
Author(s):  
Alexandra Svensson ◽  
Nina Almqvist ◽  
Annie George Chandy ◽  
Inger Nordström ◽  
Kristina Eriksson
Keyword(s):  
Allergic Asthma ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Human herpes virus type 8 seroprevalence in pregnant women in Geneva, Switzerland

2010 ◽  
Vol 24 (1) ◽  
pp. 183-185 ◽  
Author(s):  
B. Martinez de Tejada ◽  
Ingrid Steffen ◽  
Pablo Cantero ◽  
Klara M. Posfay-Barbe ◽  
Olivier Irion ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type

Control of Human Herpes Virus Type 8-Associated Diseases by NK Cells

2007 ◽  
Vol 1096 (1) ◽  
pp. 37-43 ◽  
Author(s):  
M. C. SIRIANNI ◽  
M. CAMPAGNA ◽  
D. SCARAMUZZI ◽  
M. CARBONARI ◽  
E. TOSCHI ◽  
...  
Keyword(s):  
Nk Cells ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Associated Diseases ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type
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