Accumulation of factor F395 in nifNE mutants of Klebsiella pneumoniae

1993 ◽  
Vol 39 (3) ◽  
pp. 351-354
Author(s):  
Diana M. Downs ◽  
Paul W. Ludden ◽  
Vinod K. Shah
Keyword(s):  
Nitrogen Fixation ◽  
Klebsiella Pneumoniae ◽  
Small Molecule ◽  
Molybdenum Cofactor ◽  
Gene Products ◽  
In Vitro Synthesis ◽  
Iron Molybdenum Cofactor

The nifNE gene products of Klebsiella pneumoniae are required for the in vivo and in vitro synthesis of the iron-molybdenum cofactor (FeMo-co) of nitrogenase. Derepression of nifNE mutants for nitrogenase resulted in the accumulation of a small molecule, factor F395. Factor F395 is protein associated in vivo. We report here initial spectral characterization of this factor.Key words: FeMo-co, nitrogen fixation, Klebsiella pneumoniae, nifNE.

Dinitrogenase with altered substrate specificity results from the use of homocitrate analogs for in vitro synthesis of the iron-molybdenum cofactor

Biochemistry ◽  
1988 ◽  
Vol 27 (10) ◽  
pp. 3647-3652 ◽  
Author(s):  
Timothy R. Hoover ◽  
Juan Imperial ◽  
Jihong Liang ◽  
Paul W. Ludden ◽  
Vinod K. Shah
Keyword(s):  
Substrate Specificity ◽  
Molybdenum Cofactor ◽  
In Vitro Synthesis ◽  
Iron Molybdenum Cofactor

In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

Xenobiotica ◽  
2018 ◽  
Vol 49 (6) ◽  
pp. 718-733 ◽  
Author(s):  
Mark P. Grillo ◽  
John C. L. Erve ◽  
Ryan Dick ◽  
James P. Driscoll ◽  
Nicole Haste ◽  
...  
Keyword(s):  
Small Molecule ◽  
Allosteric Modulator ◽  
Cardiac Myosin

scholarly journals In vitro synthesis of the iron-molybdenum cofactor of nitrogenase.

1986 ◽  
Vol 83 (6) ◽  
pp. 1636-1640 ◽  
Author(s):  
V. K. Shah ◽  
J. Imperial ◽  
R. A. Ugalde ◽  
P. W. Ludden ◽  
W. J. Brill
Keyword(s):  
Molybdenum Cofactor ◽  
In Vitro Synthesis ◽  
Iron Molybdenum Cofactor

Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class

2016 ◽  
Author(s):  
Adam B. Keeton ◽  
Bing Zhu ◽  
Kevin J. Lee ◽  
Joshua C. Canzoneri ◽  
Sara C. Sigler ◽  
...  
Keyword(s):  
Small Molecule ◽  
In Vivo Characterization

scholarly journals Characterization of extended-spectrum-β-lactamase producing Klebsiella pneumoniae phage KP1801 and evaluation of therapeutic efficacy in vitro and in vivo

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Phitchayapak Wintachai ◽  
Ampapan Naknaen ◽  
Jirapath Thammaphet ◽  
Rattanaruji Pomwised ◽  
Narumon Phaonakrop ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Therapeutic Efficacy ◽  
Extended Spectrum
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