Gene for integrin-associated protein (IAP, CD47): Physical mapping, genomic structure, and expression studies in skeletal muscle
Keyword(s):
Integrin-associated protein (IAP) is a widely expressed membrane protein with multiple functions in immunological and neuronal processes. Having physically mapped the IAP gene into a BAC/PAC contig covering approximately 1 Mb on human chromosome 3q13.1-q13.2, we determined the genomic organization of the gene, established its expression in skeletal muscle, and identified a novel splice variant. Our expression studies demonstrate expression of integrin-associated protein in the t-tubular system and the euchromatin of skeletal muscle cells where its function thus far is not known.Key words: integrin-associated protein, novel splice form, expression and subcellular localization in skeletal muscle, genomic organization.
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1972 ◽
Vol 59
(3)
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pp. 347-359
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1971 ◽
Vol 58
(6)
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pp. 700-701
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1992 ◽
Vol 182
(2)
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pp. 794-801
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2001 ◽
Vol 10
(2)
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pp. 90-94
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