STUDIES OF PHLORIDZIN IN MALUS

1959 ◽  
Vol 37 (7) ◽  
pp. 901-910 ◽  
Author(s):  
A. Hutchinson ◽  
C. D. Taper ◽  
G. H. N. Towers

The phloridzin content of dormant terminal twigs of Malus rootstock clones was not related to the vigor imparted to the scions. In young seedling trees it varied with the nutritional status of the plant; an acute deficiency of nitrogen, sulphur, or calcium resulted in a significant increase in phloridzin accumulation. Phloridzin is synthesized readily in the leaf from C14O2 in the light and appears to be stable once formed. Phenylalanine-C14 and tyrosine-C14, when fed to leaf disks, are incorporated into the C6–C3 moiety of phloridzin which includes ring B. Tyrosine is not as effective as phenylalanine. Acetate-C14 is incorporated into ring A. Phloroglucinol is not involved in the synthesis of phloridzin. A method for the quantitative determination of phloridzin is described, also a semimicro method for its alkaline hydrolysis. The large amounts of radioactive D-glucitol formed from a wide variety of precursor compounds indicate a central role for it in the carbohydrate metabolism of Malus.

1959 ◽  
Vol 37 (1) ◽  
pp. 901-910 ◽  
Author(s):  
A. Hutchinson ◽  
C. D. Taper ◽  
G. H. N. Towers

The phloridzin content of dormant terminal twigs of Malus rootstock clones was not related to the vigor imparted to the scions. In young seedling trees it varied with the nutritional status of the plant; an acute deficiency of nitrogen, sulphur, or calcium resulted in a significant increase in phloridzin accumulation. Phloridzin is synthesized readily in the leaf from C14O2 in the light and appears to be stable once formed. Phenylalanine-C14 and tyrosine-C14, when fed to leaf disks, are incorporated into the C6–C3 moiety of phloridzin which includes ring B. Tyrosine is not as effective as phenylalanine. Acetate-C14 is incorporated into ring A. Phloroglucinol is not involved in the synthesis of phloridzin. A method for the quantitative determination of phloridzin is described, also a semimicro method for its alkaline hydrolysis. The large amounts of radioactive D-glucitol formed from a wide variety of precursor compounds indicate a central role for it in the carbohydrate metabolism of Malus.


1918 ◽  
Vol 27 (1) ◽  
pp. 49-63 ◽  
Author(s):  
John Auer ◽  
Israel S. Kleiner

The subcutaneous injection of 1 or 2 mg. of morphine sulfate per kilo subcutaneously in dogs with a pancreatic deficiency, whose sugar tolerance is still good, produces a rise in the glycemia about four times greater than the same amount of morphine calls forth in normal dogs. As dogs with a pancreatic deficiency due to coagulation or partial resection of the gland may legitimately be considered in a prediabetic state, the inference is warranted that the morphine test may be of value in detecting a weakened carbohydrate metabolism in the human subject. The test could easily and without danger be carried out with the micro methods now available for the quantitative determination of blood sugar. The experimental facts described in this paper give additional corroboration to the view that the response of a normal and of a pathologically altered organism to the same drug in the same dosage may be quantitatively very different.


1999 ◽  
Vol 96 (9/10) ◽  
pp. 1608-1615
Author(s):  
T. E. Malliavin ◽  
H. Desvaux ◽  
M. A. Delsuc

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Koşar ◽  
F Göger ◽  
N Kırımer ◽  
KHC Başer

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
FHA Fernandes ◽  
RSA Batista ◽  
G Véras ◽  
FS Souza ◽  
ACD Medeiros

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