ON THE OXIDATION OF 1, 1, 1-TRICHLORO-2,2-BIS- (p-TOLYL) -ETHANE

1953 ◽  
Vol 31 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Yvon Perron
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Glacial Acetic Acid ◽  
Chloral Hydrate ◽  
Chromium Trioxide ◽  
Condensation Product ◽  
Potassium Dichromate ◽  
Oxidative Degradation ◽  
Amide Derivatives ◽  
Derivatives Of

The condensation of benzene with chloral hydrate in the presence of concentrated sulphuric acid gave rise to 1,1,1-trichloro-2,2-bis-(p-tolyl)-ethane. The oxidation of this condensation product with potassium dichromate in dilute sulphuric acid at the boiling temperature yielded 1,1-dichloro-2,2-bis-(p-carboxyphenyl)-ethylene, the structure of which was shown by its oxidative degradation to 4,4′-dicarboxybenzophenone. When the oxidation of the same condensation product was carried out in the cold, with the aid of chromium trioxide in glacial acetic acid and acetic anhydride, 1,1,1-trichloro-2,2-bis-(p-carboxyphenyl)-ethane was obtained in a good yield. This last compound was converted to the dichloroethylenic-dicarboxylic acid upon refluxing with a methanolic solution of sodium hydroxide. The corresponding amide derivatives of both the dichloro and trichlorodicarboxylic acids were also prepared.

scholarly journals Synthesis and Prognosis of Anti-inflammatory Activity of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3h)-one

2021 ◽  
Vol 7 (12) ◽  
pp. 25-33
Author(s):  
A. Chiriapkin ◽  
I. Kodonidi ◽  
A. Ivchenko ◽  
L. Smirnova
Keyword(s):  
Acetic Acid ◽  
Biological Activity ◽  
Dimethyl Sulfoxide ◽  
In Silico ◽  
Glacial Acetic Acid ◽  
Inflammatory Activity ◽  
Modified Method ◽  
Anti Inflammatory ◽  
Catalytic Addition ◽  
Derivatives Of

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclization of azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide in the medium of glacial acetic acid with the catalytic addition of dimethyl sulfoxide. Preliminary prognosis of anti-inflammatory activity in silico method allowed us to identify the most promising compounds. Of these, the 4b structure containing a 2-hydroxyphenyl fragment in the second position of pyrimidine-4(3H)-one may be of the greatest interest. It seems appropriate to further study the spectrum of biological activity of the studied compounds.

scholarly journals PYRIMIDINES AS POTENT CYTOTOXIC AND ANTI-INFLAMMATORY AGENTS

2017 ◽  
Vol 10 (6) ◽  
pp. 237 ◽  
Author(s):  
Ishwar Bhat K ◽  
Abhishek Kumar
Keyword(s):  
Acetic Acid ◽  
Cytotoxic Activity ◽  
Glacial Acetic Acid ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Cytotoxic Agents ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Derivatives Of

Objective: Many derivatives of pyrimidine are known for the broad-spectrum biological activities such as antimicrobial, antitumor, antibacterial, antitubercular, anti-inflammatory, and cytotoxic activity. Chalcones with an enone group show potent pharmacological activities such as antiinflammatory, antibacterial, antifungal, and antimalarial activity. A series of pyrimidines from chalcones have been synthesized and screened for anti-inflammatory and cytotoxic activity studies.Methods: Chalcones [1-(4-nitrophenyl)-3-substituted-phenylprop-2-en-1-one] were synthesized from various substituted aldehydes with 4-nitroacetophenone and cyclized with urea and glacial acetic acid to give pyrimidine derivatives [4-(4-nitrophenyl)-6-substituted-phenylpyrimidin-2-ol].Results: Anti-inflammatory and cytotoxic activity studies revealed that some of the synthesized compounds have shown significant activity.Conclusion: The observed results proved that pyrimidines are found to be interesting lead molecules for the synthesis of anti-inflammatory and cytotoxic agents

On the proteid reaction of Adamkiewicz, with contributions to the chemistry of glyoxylic acid

1901 ◽  
Vol 68 (442-450) ◽  
pp. 21-33 ◽  
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Glacial Acetic Acid ◽  
Glyoxylic Acid ◽  
Violet Colour

In 1874 Adamkiewicz* described the now familiar reaction which results in the production of a violet colour when strong sulphuric acid is added to the solution of a proteid in glacial acetic acid. Adam­kiewicz did not apparently look upon the employment of the acetic acid as introducing anything beyond a certain modification of the action of sulphuric acid.

THE ACTION OF SULPHURIC ACID ON CERTAIN DERIVATIVES OF CYCLOPROPANE

1933 ◽  
Vol 9 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Charles F. H. Allen ◽  
Raymond Boyer
Keyword(s):  
Acetic Acid ◽  
Sulphuric Acid ◽  
Hydrogen Bromide ◽  
Cyclopropane Ring ◽  
Secondary Reaction ◽  
Derivatives Of ◽  
Cyclopropane Derivatives

A considerable variety of ketocyclopropanes has been submitted to the action of sulphuric acid, alone or in acetic acid. In general, the mode of reaction was similar to, though less drastic than, that of hydrogen bromide; this indicated a similar mechanism. When the cyclopropane ring was attacked, the product isolated was apparently formed by the addition of a molecule of water or acetic acid, or was the result of a secondary reaction dependent on a primary product so formed. The nitriles were hydrolyzed to amides without opening of the ring. A mechanism is suggested to account for the ring scission of cyclopropyl alcohols, which takes place in a different manner from most cyclopropane derivatives.

Oxidation of carbohydrates with chromium trioxide in acetic acid. II. Acetals. A new synthesis of ketoses

1971 ◽  
Vol 24 (6) ◽  
pp. 1219 ◽  
Author(s):  
SJ Angyal ◽  
K James
Keyword(s):  
Acetic Acid ◽  
Chromium Trioxide ◽  
Keto Form ◽  
New Synthesis ◽  
Derivatives Of

Oxidation of fully acylated methylene and benzylidene acetals of alditols with chromium trioxide in acetic acid yields fully acylated ketoses in their keto form. Derivatives of hex-3-uloses have been prepared by this method. Syntheses of 3,4-O-methylene-D-mannitol and 3,4-O-methylene-D-glucitol are described.

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