Vibrational spectroscopic studies of molecular associations by local anesthetics
1980 ◽
Vol 58
(19)
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pp. 2080-2088
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Keyword(s):
Infrared spectroscopic studies have been performed on H-bonding for a number of local anesthetics: benzocaine, procaine, tetracaine, lidocaine, dibucaine, and three barbiturates: phenobarbital, pentobarbital, and thiopental. All these compounds have a marked tendency for self-association. When they are put into contact with systems containing H-bonds of the [Formula: see text], [Formula: see text], or [Formula: see text] types, however, the degree of self-association decreases and new H-bonds are formed at the expense of the former. The possible consequences of this for the chemical mechanism of anesthesia are briefly discussed.
2000 ◽
Vol 23
(2)
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pp. 187-197
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2005 ◽
Vol 39
(2)
◽
pp. 144-150
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1997 ◽
Vol 408-409
◽
pp. 467-472
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