Microstructural and Photoacoustic Infrared Spectroscopic Studies of Human Cortical Bone with Osteogenesis Imperfecta

JOM ◽  
2016 ◽  
Vol 68 (4) ◽  
pp. 1116-1127 ◽  
Author(s):  
Chunju Gu ◽  
Dinesh R. Katti ◽  
Kalpana S. Katti
Keyword(s):  
Osteogenesis Imperfecta ◽  
Cortical Bone ◽  
Spectroscopic Studies ◽  
Human Cortical Bone ◽  
Infrared Spectroscopic

Microstructure, Spectroscopic Studies and Nanomechanical Properties of Human Cortical Bone with Osteogenesis Imperfecta

2014 ◽  
Vol 1621 ◽  
pp. 163-168
Author(s):  
Chunju Gu ◽  
Dinesh R. Katti ◽  
Kalpana S. Katti
Keyword(s):  
Fourier Transform ◽  
Osteogenesis Imperfecta ◽  
Cortical Bone ◽  
Type I Collagen ◽  
Experimental Studies ◽  
Spectroscopic Studies ◽  
Type I ◽  
Healthy Human ◽  
Electron Microscopies ◽  
Human Cortical Bone

ABSTRACTBone is a natural protein (collagen)-mineral (hydroxyapatite) nanocomposite with hierarchically organized structure. Our previous work has demonstrated orientational differences in stoichiometry of hydroxyapatite resulting from orientationally dependent collagen-mineral interactions in bone. The nature of these interactions has been investigated both through molecular dynamics simulations as well as nanomechanical and infrared spectroscopic experiments. In this study, we report experimental studies on human cortical bone with osteogenesis imperfecta (OI), a disease characterized by fragility of bones and other tissues rich in type I collagen. About 90% of OI cases result from causative variant in one of the two structural genes (COL1A1 or COL1A2) for type I procollagens. OI provides an interesting platform for investigating how alterations of collagen at the molecular level cause changes in structure and mechanics of bone. Fourier transform spectroscopy, electron microscopy (SEM), and nanomechanical experiments describe the structural and molecular differences in bone ultrastructure due to presence of diseases. Photoacoustic-Fourier transform infrared spectroscopy (PA-FTIR) experiments have been conducted to investigate the orientational differences in molecular structure of OI bone, which is also compared with that of healthy human cortical bone. Further, in situ SEM static nanomechanical testing is conducted in the transverse and longitudinal directions in the OI bone. Microstructural defects and abnormities of OI bone were ascertained using scanning electron microscopies. These results provide an insight into molecular basis of deformation and mechanical behavior of healthy human bone and OI bone.

Anisotropic properties of human cortical bone with osteogenesis imperfecta

2015 ◽  
Vol 15 (1) ◽  
pp. 155-167 ◽  
Author(s):  
Kalpana S. Katti ◽  
Chunju Gu ◽  
Dinesh R. Katti
Keyword(s):  
Osteogenesis Imperfecta ◽  
Cortical Bone ◽  
Anisotropic Properties ◽  
Human Cortical Bone

Infrared spectroscopic studies of wind-tunnel contamination

1998 ◽  
Author(s):  
A. Walker ◽  
D. Plusquellic ◽  
G. Fraser ◽  
A. Weber ◽  
W. Lafferty
Keyword(s):  
Wind Tunnel ◽  
Spectroscopic Studies ◽  
Infrared Spectroscopic

In-situ infrared spectroscopic studies of hydroxyl in amphiboles at high pressure

2016 ◽  
Vol 101 (3) ◽  
pp. 706-712 ◽  
Author(s):  
Elizabeth C. Thompson ◽  
Andrew J. Campbell ◽  
Zhenxian Liu
Keyword(s):  
High Pressure ◽  
Spectroscopic Studies ◽  
Infrared Spectroscopic

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates

Biomaterials ◽  
2014 ◽  
Vol 35 (21) ◽  
pp. 5472-5481 ◽  
Author(s):  
Elizabeth A. Zimmermann ◽  
Bernd Gludovatz ◽  
Eric Schaible ◽  
Björn Busse ◽  
Robert O. Ritchie
Keyword(s):  
Cortical Bone ◽  
Fracture Resistance ◽  
Strain Rates ◽  
Physiological Strain ◽  
Length Scales ◽  
Human Cortical Bone ◽  
Multiple Length Scales
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