Enzymatic degradation of somatostatin by rat plasma and hypothalamus
1978 ◽
Vol 56
(5)
◽
pp. 840-843
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Keyword(s):
A highly sensitive and specific radioimmunoassay for somatostatin has been used to study inactivation of the neurohormone by plasma and hypothalamic peptidase(s). Specificity of the inactivation process was indicated by the absence of interference by addition of luteinizing hormone releasing hormone, thyrotropin-releasing hormone, oxytocin, or substance P. The inactivating ability of hypothalamic tissue and plasma was destroyed by heating and the protease inhibitor benzamidine prevented plasma activity, thus suggesting the enzymatic nature of the processes involved. The present data suggest that the inactivation of somatostatin by hypothalamus and plasma could be an important factor in the regulation of circulating somatostatin levels.
2005 ◽
Vol 15
(6)
◽
pp. 435-438
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1996 ◽
Vol 729
(1-2)
◽
pp. 137-142
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1974 ◽
Vol 61
(1)
◽
pp. 95-103
◽
1982 ◽
Vol 37
(8)
◽
pp. 1075-1081
◽
1992 ◽
Vol 104
(5-6)
◽
pp. 581-590