Isolation of an N-alkylprotoporphyrin IX from chick embryo livers following the administration of 3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine
1987 ◽
Vol 65
(7)
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pp. 1500-1502
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Keyword(s):
The ferrochelatase-lowering activity of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) analogues in chick embryo hepatocyte culture has been assumed to be due to the formation of an N-alkylprotoporphyrin IX. This assumption required confirmation. For this reason the 4-ethyl analogue of DDC was administered to phenobarbital-pretreated 19-day-old chick embryos. This resulted in hepatic accumulation of a green pigment with ferrochelatase-inhibitory activity. The green pigment was identified as an N-alkylprotoporphyrin IX by comparison of the electronic absorption spectra of its dimethyl ester and Zn complex with the corresponding spectra obtained from synthetic N-ethylprotoporphyrin IX.
2012 ◽
Vol 32
(1)
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pp. 121
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1984 ◽
Vol 49
(3)
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pp. 680-683
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1995 ◽
Vol 60
(10)
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pp. 1621-1633
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1998 ◽
Vol 63
(5)
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pp. 628-635
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2009 ◽
Vol 74
(2)
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pp. 520-529
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The Electronic Absorption Spectra of Fatty Acid Mono-, Bi-, and Multilayers with Bivalent Metal Ions
1981 ◽
Vol 54
(4)
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pp. 1208-1216
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1992 ◽
Vol 48
(7)
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pp. 983-991
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1988 ◽
Vol 110
(7)
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pp. 2157-2164
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