Calibration and Fitness Analysis of the [GLP & MEMM] Model

2011 ◽  
pp. 99-110
Keyword(s):  
Fitness Analysis

scholarly journals Development of Anisotropic Hyper-Elastic Shells Using Polyconvex Strain Energy Function with Application to Clothing Fitness Analysis

2010 ◽  
Vol 76 (763) ◽  
pp. 274-282 ◽  
Author(s):  
Masato TANAKA ◽  
Hirohisa NOGUCHI ◽  
Masaki FUJIKAWA ◽  
Masami SATO ◽  
Shuya OI ◽  
...  
Keyword(s):  
Energy Function ◽  
Strain Energy ◽  
Strain Energy Function ◽  
Elastic Shells ◽  
Hyper Elastic ◽  
Fitness Analysis

scholarly journals Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Dimitrios Evangelopoulos ◽  
Gareth A. Prosser ◽  
Angela Rodgers ◽  
Belinda M. Dagg ◽  
Bhagwati Khatri ◽  
...  
Keyword(s):  
Biological Factor ◽  
Resistance Mutations ◽  
Compensatory Mechanisms ◽  
Medical Problems ◽  
Antibiotic Resistant ◽  
Clinical Resistance ◽  
Resistant Strains ◽  
Rate Of Emergence ◽  
Fitness Analysis

Abstract Drug resistant infections represent one of the most challenging medical problems of our time. D-cycloserine is an antibiotic used for six decades without significant appearance and dissemination of antibiotic resistant strains, making it an ideal model compound to understand what drives resistance evasion. We therefore investigated why Mycobacterium tuberculosis fails to become resistant to D-cycloserine. To address this question, we employed a combination of bacterial genetics, genomics, biochemistry and fitness analysis in vitro, in macrophages and in mice. Altogether, our results suggest that the ultra-low rate of emergence of D-cycloserine resistance mutations is the dominant biological factor delaying the appearance of clinical resistance to this antibiotic. Furthermore, we also identified potential compensatory mechanisms able to minimize the severe fitness costs of primary D-cycloserine resistance conferring mutations.

scholarly journals A Quantitative Fitness Analysis Workflow

10.3791/4018 ◽  
2012 ◽  
Author(s):  
A.P. Banks ◽  
C. Lawless ◽  
D.A. Lydall
Keyword(s):  
Analysis Workflow ◽  
Fitness Analysis

On the Fitness between Law and Economics—Or Sunstein between Posner and Calabresi

Global Jurist ◽  
2019 ◽  
Vol 19 (3) ◽  
Author(s):  
Fabrizio Esposito
Keyword(s):  
Economic Analysis ◽  
Law And Economics ◽  
Remarkable Difference ◽  
Economic Analysis Of Law ◽  
Bilateral Relationship ◽  
Minimalist Approach ◽  
Fitness Analysis

Abstract This article strengthens Calabresi’s call for a bilateral relationship between law and economics with two claims. The first claim is that the fitness analysis of Law and Economics (“concept-based fitness”) requires studying legal reasons and reasoning. This is a remarkable difference with the fitness analysis performed by the Economic Analysis of Law (“effect-based fitness”). Accordingly, Law and Economics and Economic Analysis of Law differ at the fitness stage already. The second claim is that Sunstein’s research on minimalism resonates well with Calabresi’s project although Sunstein has failed to acknowledge this in his book review. The article concludes with a discussion of how a minimalist approach contributes to a bilateral relationship between economics and law.

Sign in / Sign up

Export Citation Format

Share Document