Moxibustion at ST36 Alleviates Pain in Complete Freund's Adjuvant-Induced Arthritic Rats

2006 ◽  
Vol 34 (01) ◽  
pp. 57-67 ◽  
Author(s):  
Jae-Hyo Kim ◽  
Hee-Kee Kim ◽  
Yong-Il Park ◽  
In-Churl Sohn ◽  
Dong-Ok Choi ◽  
...  
Keyword(s):  
Protein Expression ◽  
Rat Model ◽  
Antinociceptive Effect ◽  
Complete Freund’S Adjuvant ◽  
No Production ◽  
Western Blots ◽  
Antinociceptive Effects ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

This study was to investigate the antinociceptive effects of moxibustion in a complete Freund's adjuvant (CFA)-induced arthritic rat model, and the effects of moxibustion on immunohistochemical changes at the spinal cord level. Moxibustion was applied to the ipsilateral (right) Zusanli (ST36) acupoint to the lesion side for 9 days to CFA-induced arthritic rats. The stepping force was measured as a behavioral test, c-Fos immunohistochemistry, NO production and nNOS Western blots were examined to evaluate antinociceptive effects. Moxibustion at ST36 significantly improved the stepping force in the affected hind limb in CFA-induced arthritis. Moreover, moxibustion at ST36 suppressed the production of NO and the protein expression of c-Fos and nNOS induced by arthritis. These results suggest that moxibustion at ST36 has a potent antinociceptive effect in an arthritic rat model, and modulates neuronal excitability and endogenous NO production by suppressing c-Fos and nNOS protein expression.

A rat model of bone inflammation-induced pain by intra-tibial complete Freund's adjuvant injection

2011 ◽  
Vol 490 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Chang-Jiang Yang ◽  
Xiao-Wei Wang ◽  
Xiu Li ◽  
Gen-Cheng Wu ◽  
Yan-Qing Wang ◽  
...  
Keyword(s):  
Rat Model ◽  
Complete Freund’S Adjuvant ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Bone Inflammation

scholarly journals Antinociceptive Effect ofTephrosia sinapouExtract in the Acetic Acid, Phenyl-p-benzoquinone, Formalin, and Complete Freund’s Adjuvant Models of Overt Pain-Like Behavior in Mice

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Renata M. Martinez ◽  
Ana C. Zarpelon ◽  
Talita P. Domiciano ◽  
Sandra R. Georgetti ◽  
Marcela M. Baracat ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Antinociceptive Effect ◽  
Complete Freund’S Adjuvant ◽  
Dependent Manner ◽  
Routes Of Administration ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Tephrosia toxicaria, which is currently known asTephrosia sinapou(Buc’hoz) A. Chev. (Fabaceae), is a source of compounds such as flavonoids.T. sinapouhas been used in Amazonian countries traditional medicine to alleviate pain and inflammation. The purpose of this study was to evaluate the analgesic effects ofT. sinapouethyl acetate extract in overt pain-like behavior models in mice by using writhing response and flinching/licking tests. We demonstrated in this study thatT. sinapouextract inhibited, in a dose (1–100 mg/kg) dependent manner, acetic acid- and phenyl-p-benzoquinone- (PBQ-) induced writhing response. Furthermore, it was active via intraperitoneal, subcutaneous, and peroral routes of administration.T. sinapouextract also inhibited formalin- and complete Freund’s adjuvant- (CFA-) induced flinching/licking at 100 mg/kg dose. In conclusion, these findings demonstrate thatT. sinapouethyl acetate extract reduces inflammatory pain in the acetic acid, PBQ, formalin, and CFA models of overt pain-like behavior. Therefore, the potential of analgesic activity ofT. sinapouindicates that it deserves further investigation.

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