Anti-inflammatory and Radical Scavenge Effects of Arctium lappa

1996 ◽  
Vol 24 (02) ◽  
pp. 127-137 ◽  
Author(s):  
Chun-Ching Lin ◽  
Jer-Min Lin ◽  
Jeng-Jer Yang ◽  
Shu-Chuan Chuang ◽  
Takashi Ujiie
Keyword(s):  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Radical Scavenger ◽  
Scavenging Activity ◽  
Paw Edema ◽  
Arctium Lappa ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/m 11.8 mg/m1, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl4-induced hepatotoxicity could be due to the scavenging effect of A. lappa.

scholarly journals Bergenin Content and Free Radical Scavenging Activity of Bergenia Extracts

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Helena Hendrychová ◽  
Jan Martin ◽  
Lenka Tůmová ◽  
Nina Kočevar-Glavač
Keyword(s):  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Hplc Method ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Free Radical Scavengers ◽  
Radical Scavenger ◽  
Scavenging Activity ◽  
Different Seasons

Our research was focused on the evaluation of bergenin content and free radical scavenging activity of extracts prepared from three different species of Bergenia - B. crassifolia (L.) Fritsch., B. ciliata (Haw.) Sternb. and B. x ornata Stein. collected during different seasons. Using an HPLC method, the highest total amount of bergenin was revealed in the leaves of B. x ornata and B. crassifolia (4.9 - 5.1 mg.g−1). Free radical scavenging power was determined by two methods - FRAP and NADH. The best free radical scavengers were B. crassifolia (FRAP: 6.7 - 15.9 mg GAE.100g−1; NADH: 20.3 - 50.9%) and B. ornata (FRAP: 13.7 - 15.2 mg GAE.100g−1; NADH: 29.3 - 31.1%). The lowest content of bergenin and the weakest radical scavenger was B. ciliata (bergenin: 3.1 mg.g−1; FRAP: 5.5 - 11.0 mg GAE.100g−1; NADH: 23.2 - 25.6%). The presence of a large percentage of bergenin is responsible for the radical scavenging activity, as shown by the results from the FRAP and NADH assays. Significant, positive correlation was found between bergenin content and radical scavenging activity in both methods.

DPPH Free Radical Scavenger Components from the Fruits of Alpinia rafflesiana Wall. ex. Bak. (Zingiberaceae)

2004 ◽  
Vol 59 (11-12) ◽  
pp. 811-815 ◽  
Author(s):  
Habsah Mohamad ◽  
Faridah Abas ◽  
Dharma Permana ◽  
Nordin H. Lajis ◽  
Abdul Manaf Ali ◽  
...  
Keyword(s):  
Free Radical ◽  
Methanol Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Scavenging Activity ◽  
Colorimetric Analysis ◽  
Natural Sources

The methanol extract of the dried ripe fruits of Alpinia rafflesiana was investigated for its DPPH free radical scavenger constituents. 2′,3′,4′,6′-Tetrahydroxychalcone (7), which has never been isolated from natural sources was found to be most active as a DPPH free radical scavenger with the IC50 value of 55 μᴍ. Other known compounds isolated from this species include 5,6-dehydrokawain (1), flavokawin B (2), 1,7-diphenyl-5-hydroxy-6-hepten-3-one (3), (-)-pinocembrin (4), cardamonin (5) and (-)-pinostrobin (6). The DPPH free radical scavenger compounds were detected using TLC autographic analysis. The percentage inhibition of DPPH free radical scavenging activity was measured on isolates (5-7) using colorimetric analysis.

scholarly journals Evaluation of free radical scavenging activity of leaf of Hypericum mysorense Heyne

2017 ◽  
Vol 9 (4) ◽  
pp. 589
Author(s):  
Sornalakshmi V ◽  
Tresina PS ◽  
Paulpriya K ◽  
Veerabahu Ramasamy Mohan
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Ethanol Extract ◽  
Free Radical Scavenging ◽  
Model Systems ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Reducing Ability ◽  
Scavenger Activity

<em>Hypericum </em>is a well-known plant genus in herbal medicine. <em>Hypericum mysorense</em> is well known in folklore medicine for its varied therapeutic potential. The <em>in vitro </em>antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extract of leaf of <em>Hypericum mysorense </em>have been tested using various antioxidant model systems viz; DPPH, hydroxyl, superoxide, ABTS and reducing power. The scavenging effect increases with the concentration of standard and samples. Among the solvent tested, ethanol extract exhibited highest DPPH (116.33% inhibition), hydroxyl (101.84%), superoxide (116.09%) and ABTS (119.22%) radical scavenger activity. Methanol extract of <em>H.mysorense </em>shows the highest reducing ability. The aim and purpose of this study is to show the significant free radical scavenging potential of <em>H.mysorense </em>leaf which can be experimented for the treatment of various free radical mediated ailments

Synthesis, antibacterial and free radical scavenging activity of some newer N-((10-nitro-1H-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
A. Dixit ◽  
D. Pathak ◽  
G.K. Sharma
Keyword(s):  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Diffusion Method ◽  
Radical Scavenger ◽  
Scavenging Activity ◽  
Dpph Method ◽  
Antibacterial Potential

AbstractPresent research is oriented on the synthesis of some novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazoline analogs (4b1-4b11) and their characterization by 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Their free radical scavenging activity and antibacterial potential were also evaluated. Many derivatives have shown a marked free radical scavenging capacity in all the concentrations but specifically compounds 4b7, 4b8 and 4b11 have shown good antioxidant potential with an IC50 value of 25.18 μmol/L, 28.09 μmol/L ---amp--- 44.22 μmol/L, respectively (DPPH method) and 39.46 μmol/L, 44.47 μmol/L ---amp--- 35.61 μmol/L, respectively (H2O2 method). The antibacterial evaluation was carried out against B. subtilis and E. coli by agar well diffusion method and it revealed that all the compounds in the series were having marked antibacterial activity but compounds 4b9 and 4b11 have shown best antibacterial potential. Then, it was concluded that the derivatives which were containing substituted anilines (4-Nitro, 4-Fluoro, 4-Bromo ---amp--- 4-Chloro-2-nitro) on the carbon attached on the 12th position of indoloquinazoline moiety were having marked potential as an antibacterial and free radical scavenger.

scholarly journals EVALUATION OF ANTIRADICAL SCAVENGER ACTIVITY OF EXTRACT AND COMPOUNDS FROM ETLINGERA CALOPHRYS STEMS

2018 ◽  
Vol 11 (2) ◽  
pp. 238
Author(s):  
Sahidin I ◽  
Wahyuni Wahyuni ◽  
Muh Hajrul Malaka ◽  
Jabbar A ◽  
Imran Imran ◽  
...  
Keyword(s):  
Free Radical ◽  
Methanol Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Hydroxybenzoic Acid ◽  
Scavenging Activity ◽  
Scavenger Activity ◽  
Yakuchinone A

 Objective: This study was aimed to isolate and identify the chemical compounds from the methanol extract of the stems of Etlingera calophrys as well as to evaluate their potential as free radical scavengers. Methods: The isolated compounds were obtained using vacuum liquid chromatography (VLC) and radial chromatography techniques. The structures of these compounds were determined on the basis of their measured spectroscopic evidence (infrared, one dimentional (1D), and 2D nuclear magnetic resonance) and by comparison with literature data. The free radical scavenging activity of the methanol extract of the stems and the isolated compounds were measured using qualitative and quantitative 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Results: Yakuchinone A (1), p-hydroxybenzoic acid (2), and stigmasterol (3) were successfully isolated and identified from the stems of E. calophyrs. The methanol extract and compounds 1–3 showed free radical scavenging activity with half maximal inhibitory concentration (IC50) values of 38.36, 39.07, 46.60, and 153.4 μg/mL, respectively, as compared to ascorbic acid with an IC50 value of 10.53 μg/mL. Conclusions: Yakuchinone A (1) and p-hydroxybenzoic acid (2) are first reported from the genus Etlingera. The presence of these compounds may contribute to the free radical scavenging activity of the methanol extract of the stems of E. calophrys. This finding suggested that E. calophrys may serve as a source of natural antioxidant compounds and could be used in the development of antioxidant herbal preparation.

scholarly journals Antioxidant-Free Radical Scavenging of Some Euphorbiaceae Herbs

2011 ◽  
Vol 2 (1) ◽  
pp. 146
Author(s):  
Titik Sunarni ◽  
Fransiska Leviana
Keyword(s):  
Acetic Acid ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Ic50 Value ◽  
Scavenger Activity ◽  
Acetic Acid Water

In order to screen natural antioxidant, the research about antioxidant of some Euphobiaceae herbs, have been conducted. The air-dried herbs  of Euphorbia heterophylla L, Phyllanthus acidus (L.) Skeels, and Phyllanthus buxifolius Muell Arg were extracted with metanol. The obtained extract was concentrated and then suspended to produce n-hexane, ethyl acetat and aqueous fractions. Free radical scavenger activity against DPPH (1,1-diphenyl-2-pycrylhydrazyl) measured by spectrophotometric method  and the IC50 value was determined. The compounds of  active fraction had been identified by TLC method. All of the herbs showed activity as DPPH scavenger. Among these herbs, Euphorbia heterophylla L. and Phyllanthus buxifolius Muell, Arg. exhibited a strong free radical scavenging of ethyl acetat fraction with IC50 value 5,88 µg/ml and 4,64 µg/ml. The result of TLC by mobile phase n-buthanol-acetic acid-water (4:1:5) and acetic acid 15% showed flavonoid compound.Keywords: Euphorbiaceae herbs, antioxidant, DPPH, flavonoid

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