ON THE DIFFICULT INTERPLAY BETWEEN LIFE, "COMPLEXITY", AND MATHEMATICAL SCIENCES

2013 ◽  
Vol 23 (10) ◽  
pp. 1861-1913 ◽  
Author(s):  
N. BELLOMO ◽  
D. KNOPOFF ◽  
J. SOLER

This paper presents a revisiting, with developments, of the so-called kinetic theory for active particles, with the main focus on the modeling of nonlinearly additive interactions. The approach is based on a suitable generalization of methods of kinetic theory, where interactions are depicted by stochastic games. The basic idea consists in looking for a general mathematical structure suitable to capture the main features of living, hence complex, systems. Hopefully, this structure is a candidate towards the challenging objective of designing a mathematical theory of living systems. These topics are treated in the first part of the paper, while the second one applies it to specific case studies, namely to the modeling of crowd dynamics and of the immune competition.

2013 ◽  
Vol 24 (02) ◽  
pp. 405-426 ◽  
Author(s):  
D. KNOPOFF

This paper presents a development of the so-called kinetic theory for active particles to the modeling of living, hence complex, systems localized in networks. The overall system is viewed as a network of interacting nodes, mathematical equations are required to describe the dynamics in each node and in the whole network. These interactions, which are nonlinearly additive, are modeled by evolutive stochastic games. The first conceptual part derives a general mathematical structure, to be regarded as a candidate towards the derivation of models, suitable to capture the main features of the said systems. An application on opinion formation follows to show how the theory can generate specific models.


Author(s):  
Nicola Bellomo ◽  
Diletta Burini ◽  
Giovanni Dosi ◽  
Livio Gibelli ◽  
Damian Knopoff ◽  
...  

The modeling of living systems composed of many interacting entities is treated in this paper with the aim of describing their collective behaviors. The mathematical approach is developed within the general framework of the kinetic theory of active particles. The presentation is in three parts. First, we derive the mathematical tools, subsequently, we show how the method can be applied to a number of case studies related to well defined living systems, and finally, we look ahead to research perspectives.


2020 ◽  
Vol 30 (07) ◽  
pp. 1441-1460 ◽  
Author(s):  
Nicola Bellomo ◽  
Giovanni Dosi ◽  
Damián A. Knopoff ◽  
Maria Enrica Virgillito

This paper constitutes the first attempt to bridge the evolutionary theory in economics and the theory of active particles in mathematics. It seeks to present a kinetic model for an evolutionary formalization of economic dynamics. The new derived mathematical representation intends to formalize the processes of learning and selection as the two fundamental drivers of evolutionary environments [G. Dosi, M.-C. Pereira and M.-E. Virgillito, The footprint of evolutionary processes of learning and selection upon the statistical properties of industrial dynamics, Ind. Corp. Change, 26 (2017) 187–210]. To coherently represent the aforementioned properties, the kinetic theory of active particles [N. Bellomo, A. Bellouquid, L. Gibelli and N. Outada, A Quest Towards a Mathematical Theory of Living Systems (Birkhäuser-Springer, 2017)] is here further developed, including the complex interaction of two hierarchical functional subsystems. Modeling and simulations enlighten the predictive ability of the approach. Finally, we outline the potential avenues for future research.


2012 ◽  
Vol 22 (supp01) ◽  
pp. 1140006 ◽  
Author(s):  
N. BELLOMO ◽  
J. SOLER

This paper deals with the modeling and simulation of swarms viewed as a living, hence complex, system. The approach is based on methods of kinetic theory and statistical mechanics, where interactions at the microscopic scale are nonlinearly additive and modeled by stochastic games.


2006 ◽  
Vol 16 (07) ◽  
pp. 1001-1029 ◽  
Author(s):  
NICOLA BELLOMO ◽  
GUIDO FORNI

This paper deals with the development of new paradigms based on the methods of the mathematical kinetic theory for active particles to model the dynamics of large systems of interacting cells. Interactions are ruled, not only by laws of classical mechanics, but also by a few biological functions which are able to modify the above laws. The paper technically shows, also by reasoning on specific examples, how the theory can be applied to model large complex systems in biology. The last part of the paper deals with a critical analysis and with the indication of research perspectives concerning the challenging target of developing a biological-mathematical theory for the living matter.


2015 ◽  
Vol 26 (02) ◽  
pp. 207-214 ◽  
Author(s):  
N. Bellomo ◽  
F. Brezzi

This issue is devoted to complex systems in life sciences. Some perspective ideas on possible objectives of future research are extracted from the contents of this issue and brought to the reader’s attention. The final ambitious aim is the development of a mathematical theory for complex living systems.


2014 ◽  
Vol 24 (13) ◽  
pp. 2723-2742 ◽  
Author(s):  
E. De Angelis

This paper is devoted to the modeling, qualitative analysis and simulation of Darwinian selection phenomena and their evolution. The approach takes advantage of the mathematical tools of the kinetic theory of active particles which are applied to describe the selective dynamics of evolution processes. The first part of the paper focuses on a mathematical theory that has been developed to describe mutations and selection processes. The second part deals with different modeling strategies and looks ahead to research perspectives.


2013 ◽  
Vol 24 (02) ◽  
pp. 213-219 ◽  
Author(s):  
N. BELLOMO ◽  
F. BREZZI

This brief note is an introduction to the papers published in this special issue devoted to complex systems in life sciences. Out of this presentation some perspective ideas on conceivable future research objectives are extracted and brought to the reader's attention. The final (ambitious) aim is to develop a mathematical theory for complex living systems.


2017 ◽  
Vol 28 (03) ◽  
pp. 1750030 ◽  
Author(s):  
D. Burini ◽  
S. De Lillo ◽  
G. Fioriti

A vehicular traffic model is presented, based on the so-called Kinetic Theory of Active Particles. Vehicles are characterized by a lattice of discrete speeds and by the driving ability of the drivers. The evolution of the system is modeled through nonlinear interactions, whose output is described by stochastic games. The results of numerical simulations are consistent with experimental measurements of traffic flow.


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