Microcode development tools for a capability-based processor

For the growing prosperity of the hotel industry,to improve the efficiency of hotel housing management, the paper adopts J2EE platform combine with JBPM workflow technology as a workflow development tools,using the SQL Server 2008 as database to develop hotel housing management system with friendly interface,completely functions and good security.The application of the system reduces the use cost of room management of hotel, improving the room management efficiency of the hotel.

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Qualification of translational safety biomarkers

Experimental Biology and Medicine ◽

10.1177/15353702211002153 ◽

2021 ◽

pp. 153537022110021

Author(s):

John-Michael Sauer ◽

Amy C Porter

Keyword(s):

Skeletal Muscle ◽

Drug Development ◽

Vascular Injury ◽

Validation Studies ◽

Safety Assessment ◽

Regulatory Agencies ◽

Development Studies ◽

Clinical Validation ◽

Development Tools ◽

Important Drug

Safety biomarkers are important drug development tools, both preclinically and clinically. It is a straightforward process to correlate the performance of nonclinical safety biomarkers with histopathology, and ideally, the biomarker is useful in all species commonly used in safety assessment. In clinical validation studies, where histopathology is not feasible, safety biomarkers are compared to the response of standard biomarkers and/or to clinical adjudication. Worldwide, regulatory agencies have put in place processes to qualify biomarkers to provide confidence in the manner of use and interpretation of biomarker data in drug development studies. This paper describes currently qualified safety biomarkers which can be utilized to monitor for nephrotoxicity and cardiotoxicity and ongoing projects to qualify safety biomarkers for liver, skeletal muscle, and vascular injury. In many cases, the development and use of these critical drug development tools is dependent upon partnerships and the precompetitive sharing of data to support qualification efforts.

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