Calcified Coronary Artery Plaque Measurement with Cardiac CT in Population-based Studies: Standardized Protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) Study

Radiology ◽  
2005 ◽  
Vol 234 (1) ◽  
pp. 35-43 ◽  
Author(s):  
J. Jeffrey Carr ◽  
Jennifer Clark Nelson ◽  
Nathan D. Wong ◽  
Michael McNitt-Gray ◽  
Yadon Arad ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Cardiac Ct ◽  
Population Based ◽  
Coronary Artery Plaque ◽  
Ethnic Study ◽  
Standardized Protocol

Abstract P104: Higher Leptin Levels Are Associated With Increased Odds Of Coronary Artery Calcium Progression: The Multi-ethnic Study Of Atherosclerosis

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Bhavya Varma ◽  
Oluseye Ogunmoroti ◽  
Chiadi Ndumele ◽  
Di Zhao ◽  
Moyses Szklo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Cardiac Ct ◽  
Subclinical Atherosclerosis ◽  
Community Dwelling ◽  
Ct Scans ◽  
Agatston Score ◽  
Cvd Risk ◽  
Ethnic Study ◽  
History Of

Background: Adipokines are secreted by adipose tissue, play a role in cardiometabolic pathways, and have differing associations with cardiovascular disease (CVD). Coronary artery calcium (CAC) and its progression indicate subclinical atherosclerosis and prognosticate CVD risk. However the association of adipokines with CAC progression is not well established. We examined the association of adipokines with the odds of a history of CAC progression in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: We performed an analysis of 1,904 community dwelling adults free of clinical CVD in MESA. Participants underwent measurement of serum adipokines [leptin, resistin and adiponectin] at visits 2 or 3 (randomly assigned) and a contemporaneous cardiac CT scan at same visit. Participants also had a prior cardiac CT at visit 1, at a median of 2.4 years earlier. On both CTs, CAC was quantified by Agatston score. We defined a history of CAC progression between the CT scans at visit 1 and at visit 2 or 3 as those with >0 Agatston units of change per year (and compared to those with ≤0 units of change per year). We used logistic regression to examine the odds of having a history of CAC progression by adipokine tertiles using progressively adjusted models. Results: The mean participant age was 65 (10) years; 50% were women, 40% White, 13% Chinese, 21% Black and 26% Hispanic. The prevalences of CAC at visits 1 and 2/3 were 49% and 58%, respectively. There were 1,001 (53%) who had CAC progression between the 2 CT scans. In demographic-adjusted models (model 1, Table), higher leptin and lower adiponectin were associated with increased odds of prior CAC progression. In models fully adjusted for BMI and other CVD risk factors (model 3), only the highest tertile of leptin remained associated with a greater odds of prior CAC progression [OR 1.55 (95% CI 1.04, 2.30)]. Conclusions: Higher leptin levels were independently associated with a history of CAC progression. Atherosclerosis progression may be one mechanism through which leptin confers increased CVD risk

scholarly journals The Association Between Serum LDL level and the Presence of Non-Calcified Coronary Artery Plaque in Young Adults

2020 ◽  
Vol 3 ◽  
pp. 100043
Author(s):  
Negin Nezarat ◽  
Khadije Ahmad ◽  
Vahid Rezvanizadeh ◽  
Ahmed Ghanem ◽  
Sajad Hamal ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Coronary Artery Plaque

scholarly journals The Association of Pericardial Fat with Coronary Artery Plaque Index at MR Imaging: The Multi-Ethnic Study of Atherosclerosis (MESA)

Radiology ◽  
2011 ◽  
Vol 261 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Cuilian Miao ◽  
Shaoguang Chen ◽  
Jingzhong Ding ◽  
Kiang Liu ◽  
Debiao Li ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Mr Imaging ◽  
Plaque Index ◽  
Coronary Artery Plaque ◽  
Pericardial Fat ◽  
Ethnic Study

scholarly journals CORONARY ARTERY CALCIUM AND INCIDENT HYPERTENSION IN A POPULATION-BASED COHORT: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS

2017 ◽  
Vol 69 (11) ◽  
pp. 1763
Author(s):  
Amer I. Aladin ◽  
Mahmoud Al Rifai ◽  
Shereen H. Rasool ◽  
Zeina Dardari ◽  
Joseph Yeboah ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Population Based ◽  
Incident Hypertension ◽  
Ethnic Study

Repeatability Limits for Measurement of Coronary Artery Calcified Plaque with Cardiac CT in the Multi-Ethnic Study of Atherosclerosis

2008 ◽  
Vol 190 (2) ◽  
pp. W87-W92 ◽  
Author(s):  
Hyoju Chung ◽  
Robyn L. McClelland ◽  
Ronit Katz ◽  
J. Jeffrey Carr ◽  
Matthew J. Budoff
Keyword(s):  
Coronary Artery ◽  
Cardiac Ct ◽  
Ethnic Study ◽  
Coronary Artery Calcified Plaque ◽  
Calcified Plaque

Abstract 12: Volume of Calcium in the Descending Thoracic Aorta Predicts All Cause Mortality Beyond Coronary Artery Calcium: The Multi-Ethnic Study of Atherosclerosis

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Isac C Thomas ◽  
Matthew A Allison ◽  
Nketi I Forbang ◽  
Erin D Michos ◽  
WT Longstreth ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Thoracic Aorta ◽  
Coronary Artery Calcium ◽  
Regression Models ◽  
Cardiac Ct ◽  
Descending Thoracic Aorta ◽  
Predictive Values ◽  
Ethnic Study ◽  
All Cause Mortality

Introduction: Coronary artery calcium (CAC) volume and density differentially predict incident cardiovascular disease (CVD), with CAC density inversely associated with these outcomes. Whether similar associations exist between descending thoracic aortic calcium (DTAC) volume and density and all cause mortality (ACM) are unknown. We hypothesized that DTAC volume and density predict ACM independently of CAC. Methods: The Multi-Ethnic Study of Atherosclerosis enrolled 6,814 participants free of clinical CVD at baseline and followed them for incident adverse events. Cardiac CT at baseline visualized the segment of the descending thoracic aorta posterior to the heart. Only participants with prevalent DTAC were included (necessary to evaluate DTAC density). DTAC and CAC volumes were natural log transformed to adjust for skewness. Cox regression models estimated the associations of DTAC volume and density with ACM after adjustment for age, gender, ethnicity, CVD risk factors, statin use, and CAC volume and density. The incremental predictive values of DTAC volume and density were evaluated by area under receiver operating characteristic (AUC) curves. Results: Of the total cohort, 1,850 participants (27%) had prevalent DTAC and 491 deaths occurred over 10.3 years. In separate regression models, DTAC volume was independently associated with ACM after adjustment for CAC volume (HR 1.21 [95% CI 1.09-1.35]) and additional adjustment for CAC density (1.18 ([1.06-1.32]). After the same adjustments, DTAC density was not significantly associated with ACM (0.94 [0.84-1.06]). The AUC for the base Model 1 (risk factors + CAC volume) was 0.706 (0.680-0.732), which increased to 0.716 (0.690-0.742) with the addition of DTAC volume in Model 2 (p=0.03 compared to Model 1). Further addition of DTAC density in Model 3 did not improve the AUC significantly (0.717 [0.692-0.743], p=0.23 compared to Model 2). Conclusions: In a cohort free of baseline clinical CVD, DTAC visualized on cardiac CT was common. When DTAC was present, DTAC volume (but not density) was independently associated with ACM. DTAC volume also significantly improved ACM risk prediction beyond risk factors and CAC volume.

scholarly journals Association of education with dietary intake among young adults in the bi-ethnic Coronary Artery Risk Development in Young Adults (CARDIA) cohort

2003 ◽  
Vol 6 (7) ◽  
pp. 689-695 ◽  
Author(s):  
SL Archer ◽  
JE Hilner ◽  
AR Dyer ◽  
KJ Greenlund ◽  
LA Colangelo ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Black Women ◽  
Dietary Intake ◽  
White Women ◽  
Community Sample ◽  
Saturated Fat ◽  
White Men ◽  
Population Based ◽  
Health Campaigns

AbstractObjective:To examine associations of changes in dietary intake with education in young black and white men and women.Design:The Coronary Artery Risk Development in Young Adults (CARDIA) study, a multi-centre population-based prospective study. Dietary intake data at baseline and year 7 were obtained from an extensive nutritionist-administered diet history questionnaire with 700 items developed for CARDIA.Setting:Participants were recruited in 1985–1986 from four sites: Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California.Subjects:Participants were from a general community sample of 703 black men (BM), 1006 black women (BW), 963 white men (WM) and 1054 white women (WW) who were aged 18–30 years at baseline. Analyses here include data for baseline (1985–1986) and year 7 (1992–1993).Results:Most changes in dietary intake were observed among those with high education (≥ 12 years) at both examinations. There was a significant decrease in intake of energy from saturated fat and cholesterol and a significant increase in energy from starch for each race-gender group (P < 0.001). Regardless of education, taste was considered an important influence on food choice.Conclusion:The inverse relationship of education with changes in saturated fat and cholesterol intakes suggests that national public health campaigns may have a greater impact among those with more education.

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