Optic nerve coloboma (morning glory syndrome): CT findings.

Purpose:Thepurposeofthisstudyistoreportauniquecaseofmorning glorysyndrome.Methods: This study included ophthalmologic examination, opticalcoherencetomography and areviewoftherelevantliterature.Result: A 7-year-old girl with a history of morning glory syndromewas periodicallyexamined in ourclinic for5 years. Suddenly,shepresentedwiththecomplaintofdecreasedvision.Examinationsrevealed macular detachment. The visual field of the affected eye wassignificantly narrowed. OCT also revealed the presence of a fibrouscord in the centreof the optic nerve, which protruded into the vitreousbody.Discussion:Morningglorysyndromeis anuncommoncongenitaldisordercharacterizedbyawidelyenlargedpapillathatispink-orangeincolour,witha small glial tuft in thecentre. The retinalvessels are arranged radially in relation to the papilla. A pigmentedring surrounds the excavation. The incidence is not well known. Theeffectisgenerallyunilateral.Thissyndromemanifestsasopticatrophy. However, the atrophy does not progress. Visual impairmentsometimes occurs when maculardetachmentarises,as occurred inourpatient.After5yearsofobservation,ourpatient’svisiondramatically worsened as a result of macular detachment. There arevarious theories for the development of macular detachment in MGS:exudative, tractionand rhegmatogenous8.Nobreakwasfound inourpatient,sothecauseofthedetachmentwasmostlikelytheinflammatoryprocess

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Case Report: Hyperprolactinemia and growth hormone deficiency associated with Morning Glory Syndrome; with a review of the literature

F1000Research ◽

10.12688/f1000research.12655.1 ◽

2017 ◽

Vol 6 ◽

pp. 1702

Author(s):

Ravi Bhavsar ◽

Maia Pavlovic ◽

Afsoon Razavi ◽

Muhammad Umair ◽

Harsha Senapathi ◽

...

Keyword(s):

Growth Hormone ◽

Optic Nerve ◽

Gh Deficiency ◽

Optic Chiasm ◽

Morning Glory ◽

Hormone Deficiency ◽

Oral Contraceptive Pills ◽

Morning Glory Syndrome ◽

Contraceptive Pills ◽

Ocular Finding

Morning Glory Syndrome (MGS) is a rare congenital malformation of the optic nerve that is caused by a failure of the closure of the choroidal embryonic fissure in utero. The syndrome is usually seen in association with midline cranial defects, such as transsphenoidal and basal encephaloceles. Although MGS usually presents as an isolated ocular finding, it can be associated with endocrinological abnormalities. We report a case of a 32 year old female with MGS with hyperprolactinemia and growth hormone (GH) deficiency. She was diagnosed with MGS at the age of three and her past medical history was significant for left eye blindness, hyperprolactinemia and GH deficiency. She has received GH replacement and oral contraceptive pills in the past. Our investigations revealed elevated prolactin levels (63mg/l) and borderline low GH levels. Magnetic resonance imaging revealed an abnormality involving the optic chiasm, left optic nerve and compression of the pituitary gland by a basal encephalocele. Genetic studies were positive for a mutation in Paired box 6 gene (PAX6). She is being currently treated with cabergoline for her hyperprolactinemia. Our aims of this report are to highlight the hormonal manifestations of MGS and to review the etiopathogenesis of this rare disorder.

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Choroidal Neovascularization Associated with Morning Glory Syndrome: A Case Report

Archives of Clinical and Medical Case Reports ◽

10.26502/acmcr.96550293 ◽

2020 ◽

Vol 04 (06) ◽

Author(s):

Shigeru Sato ◽

Takeshi Morimoto ◽

Sayaka Tanaka ◽

Motokazu Tsujikawa ◽

Kohji Nishida

Keyword(s):

Case Report ◽

Choroidal Neovascularization ◽

Morning Glory ◽

Morning Glory Syndrome

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Congenital optic disc coloboma

Russian ophthalmology of children ◽

10.25276/2307-6658-2021-1-33-39 ◽

2021 ◽

pp. 33-39

Author(s):

A.O. Nazarenko ◽

◽

E.E. Sidorenko ◽

D.V. Miguel ◽

A.S. Smartsev ◽

...

Keyword(s):

Differential Diagnosis ◽

Optic Nerve ◽

Clinical Picture ◽

Clinical Case ◽

Charge Syndrome ◽

Diagnostic Methods ◽

Newly Diagnosed ◽

Optic Nerve Atrophy ◽

Optic Disc Coloboma ◽

Optic Nerve Coloboma

A clinical case of observation of a 3-year-old child with a newly diagnosed optic nerve coloboma and multiple malformations is considered. The clinical picture and diagnostic methods necessary for the diagnosis are reflected. On the example of this child, the differential diagnosis with Charge syndrome is considered. Key words: coloboma, optic nerve coloboma, partial optic nerve atrophy, astigmatism, Charge syndrome.

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