scholarly journals Tuning Redox Potentials of Corrole Metal Complexes and their Catalytic Activity Regarding Decomposition of Reactive Oxygen Species

2008 ◽  
Keyword(s):  
Reactive Oxygen Species ◽  
Catalytic Activity ◽  
Metal Complexes ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Redox Potentials

scholarly journals Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function

2021 ◽  
Author(s):  
Jee Hyung Sohn ◽  
Yul Ji ◽  
Chang-Yun Cho ◽  
Hahn Nahmgoong ◽  
Sangsoo Lim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Redox Potentials ◽  
Brown Adipocytes ◽  
Erk Activation ◽  
Brown Adipose ◽  
Erk Inhibition ◽  
Glucose 6 Phosphate Dehydrogenase

Reactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydrogenase (G6PD) controls cellular redox potentials by producing NADPH. Although G6PD upregulates cellular ROS levels in white adipocytes, the roles of G6PD in brown adipocytes remain elusive. Here, we found that G6PD defect in brown adipocytes impaired thermogenic function through excessive cytosolic ROS accumulation. Upon cold exposure, G6PD-deficient mutant (G6PD<sup>mut</sup>) mice exhibited cold intolerance and downregulated thermogenic gene expression in brown adipose tissue (BAT). In addition, G6PD-deficient brown adipocytes had increased cytosolic ROS levels, leading to ERK activation. In BAT of G6PD<sup>mut</sup> mice, administration of antioxidant restored the thermogenic activity by potentiating thermogenic gene expression and relieving ERK activation. Consistently, body temperature and thermogenic execution were rescued by ERK inhibition in cold-exposed G6PD<sup>mut</sup> mice. Taken together, these data suggest that G6PD in brown adipocytes would protect against cytosolic oxidative stress, leading to cold-induced thermogenesis.

scholarly journals Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase

2017 ◽  
Vol 32 (1) ◽  
pp. 1203-1208 ◽  
Author(s):  
Dres Damgaard ◽  
Mads Emil Bjørn ◽  
Peter Østrup Jensen ◽  
Claus Henrik Nielsen
Keyword(s):  
Reactive Oxygen Species ◽  
Catalytic Activity ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Peptidylarginine Deiminase

Low catalytic activity of the Cu(ii)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(i)-chelator BCS

2018 ◽  
Vol 54 (84) ◽  
pp. 11945-11948 ◽  
Author(s):  
Alice Santoro ◽  
Gulshan Walke ◽  
Bertrand Vileno ◽  
Prasad P. Kulkarni ◽  
Laurent Raibaut ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Catalytic Activity ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Redox Activity ◽  
Binding Motif ◽  
Oxygen Species ◽  
Artificial Metalloenzymes ◽  
Species Production

The application of Cu(ii)–Xxx-Zzz-His (ATCUN-peptides) as artificial metalloenzymes is limited by their low catalytic-redox activity and disruption by Cu(i)-chelators.

scholarly journals In situ observation of reactive oxygen species forming on oxygen-evolving iridium surfaces

2017 ◽  
Vol 8 (3) ◽  
pp. 2143-2149 ◽  
Author(s):  
Verena Pfeifer ◽  
Travis E. Jones ◽  
Juan J. Velasco Vélez ◽  
Rosa Arrigo ◽  
Simone Piccinin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Catalytic Activity ◽  
Reactive Oxygen ◽  
In Situ Observation ◽  
Oxygen Species ◽  
In Situ Xas ◽  
Oxygen Evolving

In situ XAS measurements reveal that electron-deficient oxygen species form during OER on IrOx and correlate with catalytic activity.

scholarly journals Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function

2021 ◽  
Author(s):  
Jee Hyung Sohn ◽  
Yul Ji ◽  
Chang-Yun Cho ◽  
Hahn Nahmgoong ◽  
Sangsoo Lim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Redox Potentials ◽  
Brown Adipocytes ◽  
Erk Activation ◽  
Brown Adipose ◽  
Erk Inhibition ◽  
Glucose 6 Phosphate Dehydrogenase

Reactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydrogenase (G6PD) controls cellular redox potentials by producing NADPH. Although G6PD upregulates cellular ROS levels in white adipocytes, the roles of G6PD in brown adipocytes remain elusive. Here, we found that G6PD defect in brown adipocytes impaired thermogenic function through excessive cytosolic ROS accumulation. Upon cold exposure, G6PD-deficient mutant (G6PD<sup>mut</sup>) mice exhibited cold intolerance and downregulated thermogenic gene expression in brown adipose tissue (BAT). In addition, G6PD-deficient brown adipocytes had increased cytosolic ROS levels, leading to ERK activation. In BAT of G6PD<sup>mut</sup> mice, administration of antioxidant restored the thermogenic activity by potentiating thermogenic gene expression and relieving ERK activation. Consistently, body temperature and thermogenic execution were rescued by ERK inhibition in cold-exposed G6PD<sup>mut</sup> mice. Taken together, these data suggest that G6PD in brown adipocytes would protect against cytosolic oxidative stress, leading to cold-induced thermogenesis.

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