Low catalytic activity of the Cu(ii)-binding motif (Xxx-Zzz-His; ATCUN) in reactive oxygen species production and inhibition by the Cu(i)-chelator BCS

2018 ◽  
Vol 54 (84) ◽  
pp. 11945-11948 ◽  
Author(s):  
Alice Santoro ◽  
Gulshan Walke ◽  
Bertrand Vileno ◽  
Prasad P. Kulkarni ◽  
Laurent Raibaut ◽  
...  

The application of Cu(ii)–Xxx-Zzz-His (ATCUN-peptides) as artificial metalloenzymes is limited by their low catalytic-redox activity and disruption by Cu(i)-chelators.

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