Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia
2020 ◽
Vol 319
(2)
◽
pp. G197-G211
Keyword(s):
We used a mouse model of gestational hypercholanemia to investigate the use of obeticholic acid (OCA), a potent FXR agonist, as a treatment for the hypercholanemia of intrahepatic cholestasis of pregnancy (ICP). The results demonstrate that OCA can improve the fetal bile acid profile. This is relevant not only to women with ICP but also for women who become pregnant while receiving OCA treatment for other conditions such as primary biliary cholangitis and nonalcoholic steatohepatitis.
2018 ◽
Vol 7
(11)
◽
pp. 4403
2016 ◽
Vol 214
(1)
◽
pp. S272
◽
1982 ◽
Vol 14
(3)
◽
pp. 153-162
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2021 ◽