Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure
2020 ◽
Vol 319
(1)
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pp. H3-H12
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Intracardiac ganglia form the final common pathway for the parasympathetic innervation of the heart. This study has used a novel chemogenetic approach within transgenic ChAT-Cre rats [expressing only Cre-recombinase in choline acetyl transferase (ChAT) neurons] to selectively increase intracardiac cholinergic parasympathetic activity to the heart in a pressure overload-induced heart failure model. The findings from this study confirm that selective activation of intracardiac cholinergic neurons lessens cardiac dysfunction and mortality seen in heart failure, identifying a novel downstream cardiac-selective target for increasing cardioprotective parasympathetic activity in heart failure.
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2017 ◽
Vol 38
(6)
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pp. 877-890
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2008 ◽
Vol 326
(3)
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pp. 957-965
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2003 ◽
Vol 2
(1)
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pp. 32
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2008 ◽
Vol 7
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pp. 102-102
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