Electroacupuncture improves cardiac function and remodeling by inhibition of sympathoexcitation in chronic heart failure rats

2014 ◽  
Vol 306 (10) ◽  
pp. H1464-H1471 ◽  
Author(s):  
Luyao Ma ◽  
Baiping Cui ◽  
Yongfeng Shao ◽  
Buqing Ni ◽  
Weiran Zhang ◽  
...  
Keyword(s):  
Infarct Size ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Heart Function ◽  
Left Ventricular ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Cardiac Sympathetic Afferent Reflex ◽  
Renal Sympathetic

Chronic heart failure (CHF) is responsible for significant morbidity and mortality worldwide, mainly as a result of neurohumoral activation. Acupuncture has been used to treat a wide range of diseases and conditions. In this study, we investigated the effects of electroacupuncture (EA) on the sympathetic nerve activity, heart function, and remodeling in CHF rats after ligation of the left anterior descending coronary artery. CHF rats were randomly selected to EA and control groups for acute and chronic experiments. In the acute experiment, both the renal sympathetic nerve activity and cardiac sympathetic afferent reflex elicited by epicardial application of capsaicin were recorded. In the chronic experiment, we performed EA for 30 min once a day for 1 wk to test the long-term EA effects on heart function, remodeling, as well as infarct size in CHF rats. The results show EA significantly decreased the renal sympathetic nerve activity effectively, inhibited cardiac sympathetic afferent reflex, and lowered the blood pressure of CHF rats. Treating CHF rats with EA for 1 wk dramatically increased left ventricular ejection fraction and left ventricular fraction shortening, reversed the enlargement of left ventricular end-systolic dimension and left ventricular end-diastolic dimension, and shrunk the infarct size. In this experiment, we demonstrated EA attenuates sympathetic overactivity. Additionally, long-term EA improves cardiac function and remodeling and reduces infarct size in CHF rats. EA is a novel and potentially useful therapy for treating CHF.

scholarly journals IGF-1 deletion affects renal sympathetic nerve activity, left ventricular dysfunction, and renal function in DOCA-salt hypertensive mice

2019 ◽  
pp. 209-217
Author(s):  
Bing Xiao ◽  
Fan Liu ◽  
Jing-Chao Lu ◽  
Fei Chen ◽  
Wei-Na Pei ◽  
...  
Keyword(s):  
Renal Function ◽  
Left Ventricular Dysfunction ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Nerve Activity ◽  
Urea Nitrogen ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic

The objective of the paper is to determine the influence of IGF-1 deletion on renal sympathetic nerve activity (RSNA), left ventricular dysfunction, and renal function in deoxycorticosterone acetate (DOCA)-salt hypertensive mice. The DOCA-salt hypertensive mice models were constructed and the experiment was classified into WT (Wild-type mice) +sham, LID (Liverspecific IGF-1 deficient mice) + sham, WT + DOCA, and LID + DOCA groups. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum IGF-1 levels in mice. The plasma norepinephrine (NE), urine protein, urea nitrogen and creatinine, as well as RSNA were measured. Echocardiography was performed to assess left ventricular dysfunction, and HE staining to observe the pathological changes in renal tissue of mice. DOCA-salt induction time-dependently increased the systolic blood pressure (SBP) of mice, especially in DOCA-salt LID mice. Besides, the serum IGF-1 levels in WT mice were decreased after DOCA-salt induction. In addition, the plasma NE concentration and NE spillover, urinary protein, urea nitrogen, creatinine and RSNA were remarkably elevated with severe left ventricular dysfunction, but the creatinine clearance was reduced in DOCA-salt mice, and these similar changes were obvious in DOCA-salt mice with IGF-1 deletion. Moreover, the DOCA-salt mice had tubular ectasia, glomerular fibrosis, interstitial cell infiltration, and increased arterial wall thickness, and the DOCA-salt LID mice were more serious in those aspects. Deletion of IGF-1 may lead to enhanced RSNA in DOCA-salt hypertensive mice, thereby further aggravating left ventricular dysfunction and renal damage.

scholarly journals Long‐term recording of renal sympathetic nerve activity in conscious rats via telemetry

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Bruce N. Van Vliet ◽  
Sarah‐Jane Guild ◽  
Carolyn Barrett ◽  
Fiona McBryde ◽  
Simon Malpas
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Conscious Rats ◽  
Renal Sympathetic Nerve ◽  
Renal Sympathetic

Central gain of the cardiac sympathetic afferent reflex in dogs with heart failure

1997 ◽  
Vol 273 (6) ◽  
pp. H2664-H2671 ◽  
Author(s):  
Rong Ma ◽  
Irving H. Zucker ◽  
Wei Wang
Keyword(s):  
Heart Failure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Sympathetic Nerves ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Failure Group ◽  
Renal Sympathetic Nerve ◽  
Cardiac Sympathetic Afferent Reflex ◽  
Renal Sympathetic

Previous studies from our laboratory have shown that the cardiac sympathetic afferent reflex is enhanced in dogs with experimental heart failure. The aim of the present study was to determine if the central gain of the cardiac sympathetic afferent reflex was also enhanced in dogs with heart failure. Fifteen dogs with pacing-induced heart failure were used in this study. Seventeen sham-operated dogs served as control. At the time of the acute experiment the dogs were anesthetized with α-chloralose. Arterial blood pressure, heart rate, and renal sympathetic nerve activity were recorded. After sinoaortic denervation and cervical vagotomy, a thoracotomy was performed in the second intercostal space. The left stellate ganglion was identified, and the left cardiac sympathetic nerves were cut. The central end of the left cardiac sympathetic nerves was placed on bipolar stimulating electrodes. The renal sympathetic nerve activity responses to electrical stimulation (30 Hz, 1 ms with varying voltages from 1 to 10 V; or 10 V, 1 ms with varying frequencies from 1 to 30 Hz) of the afferent cardiac sympathetic nerves were compared between sham and heart failure groups. Reflex renal sympathetic nerve activity responses to stimulation of the cardiac sympathetic nerves were significantly greater in the heart failure group compared with that in the sham group (21.4 ± 3.2 vs. 9.8 ± 2.9% at 10 V, 30 Hz and 27.7 ± 4.5 vs. 9.9 ± 3.4% at 30 Hz, 10 V, heart failure vs. sham group, respectively; for both relationships, P < 0.05). This enhanced central gain of the cardiac sympathetic afferent reflex in the heart failure group was significantly attenuated after intravenous and cerebroventricular injection of the angiotensin II receptor antagonist losartan (5 mg/kg iv and 0.125 mg/kg in 0.1 ml icv). These data suggest that the central gain of the cardiac sympathetic afferent reflex is enhanced in dogs with heart failure and central angiotensin II plays an important role in this enhanced response.

scholarly journals What Sets the Long-Term Level of Renal Sympathetic Nerve Activity

2003 ◽  
Vol 92 (12) ◽  
pp. 1330-1336 ◽  
Author(s):  
Carolyn J. Barrett ◽  
Rohit Ramchandra ◽  
Sarah-Jane Guild ◽  
Aneela Lala ◽  
David M. Budgett ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Renal Sympathetic
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