Cortical blood flow changes during spreading depression in cats

1991 ◽  
Vol 261 (1) ◽  
pp. H96-H102 ◽  
Author(s):  
R. D. Piper ◽  
G. A. Lambert ◽  
J. W. Duckworth
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Spreading Depression ◽  
Cerebrovascular Reactivity ◽  
Cortical Blood Flow ◽  
Cerebrovascular Activity ◽  
Vasomotor Activity ◽  
Flow Changes ◽  
Alpha Chloralose ◽  
Peak Increase

Changes in cortical blood flow and cerebrovascular activity occurring during and after cortical spreading depression (CSD) were studied in alpha-chloralose-urethan-anesthetized cats. CSD was induced by superficial cortical pinprick, and laser-Doppler velocimetry (LDV) was used to measure cerebral blood flow (CBFLD). CSD resulted in a wave of cortical hyperemia during which there was a 215 +/- 48% peak increase in cortical blood flow that lasted for 2.7 +/- 0.4 min. This hyperemic phase was followed by prolonged cortical oligemia, with a reduction in flow of 20 +/- 4% at 1 h and 28 +/- 4% at 2 h. After CSD, cerebrovascular reactivity to the inhalation of CO2 was abolished and did not fully recover for at least 10 h. Spontaneous vasomotor activity in the cerebral microcirculation was significantly decreased after CSD, and autoregulation of cortical blood flow in response to hypotension was preserved. The abnormal cerebrovascular reactivity seen after CSD in the gyrencephalic cortex of the cat has possible significance for human migraine with aura.

Regional Cortical Blood Flow at Craniotomy

Neurosurgery ◽  
1978 ◽  
Vol 2 (3) ◽  
pp. 223-229 ◽  
Author(s):  
Philip L. Carter ◽  
William L. White ◽  
James R. Atkinson
Keyword(s):  
Blood Flow ◽  
Halothane Anesthesia ◽  
Flow Probe ◽  
Cortical Blood Flow ◽  
Regional Flow ◽  
Intermittent Measurements ◽  
Flow Changes ◽  
Low Levels ◽  
Surgical Conditions ◽  
Middle Cerebral Artery Aneurysms

Abstract Regional cortical blood flow was monitored at craniotomy in 32 patients with a thermal diffusion flow probe in an attempt to assess the effects of surgical conditions on flow. Changes in flow due to vascular manipulation, retraction, hypotension, and hyperventilation were readily apparent. Eleven patients with supratentorial tumors had intermittent measurements of cerebral blood flow; the expected differences in blood flow with halothane anesthesia and hyperventilation were observed. Fourteen patients with aneurysms were monitored continuously and demonstrated a reduction in flow during hypotension; in two of these cases, the reduction was to disastrously low levels. Flow reduction occurred secondary to branch occlusion by the aneurysm clip in a patient with three middle cerebral artery aneurysms and was corrected by changing the clip position. Direct measurement of regional flow may be of value in estimating the safety of temporary clips and the degree of hypotension that can be tolerated.

Autoradiographic Identification of Kidney Angiotensin IV Binding Sites and Angiotensin IV-Induced Renal Cortical Blood Flow Changes in Rats

Peptides ◽  
1998 ◽  
Vol 19 (2) ◽  
pp. 269-277 ◽  
Author(s):  
J.K.M. Coleman ◽  
L.T. Krebs ◽  
T.A. Hamilton ◽  
B. Ong ◽  
K.A. Lawrence ◽  
...  
Keyword(s):  
Blood Flow ◽  
Binding Sites ◽  
Angiotensin Iv ◽  
Cortical Blood Flow ◽  
Renal Cortical Blood Flow ◽  
Flow Changes

Spreading depression induces prolonged reduction of cortical blood flow reactivity in the rat

1992 ◽  
Vol 117 (3) ◽  
pp. 278-286 ◽  
Author(s):  
P. Lacombe ◽  
R. Sercombe ◽  
J.L. Correze ◽  
V. Springhetti ◽  
J. Seylaz
Keyword(s):  
Blood Flow ◽  
Spreading Depression ◽  
Cortical Blood Flow

rCBF After Tia and during Migraine Attacks

Cephalalgia ◽  
1985 ◽  
Vol 5 (2_suppl) ◽  
pp. 43-46 ◽  
Author(s):  
Jes Olesen ◽  
Sissel Vorstrup ◽  
Martin Lauritzen
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
Carotid Stenosis ◽  
Regional Cerebral Blood Flow ◽  
Spreading Depression ◽  
Cerebral Damage ◽  
Regional Cerebral Blood ◽  
Flow Changes ◽  
Ct Studies

TIA is usually caused by embolism from a carotid stenosis. The stenosis has no hemodynamic significance, but recent studies of regional cerebral blood flow have indicated that this occurs in a few cases. Traditionally, TIA are not considered to cause cerebral damage, but CT-studies have revealed a number of silent infarcts and rCBF measurements have shown even more persistent abnormalities of blood flow. In classic migraine, alterations of rCBF are completely different, indicating a mechanism progressing in the cerebral cortex, probably the spreading depression of Leao. Similar blood flow changes are not seen in common migraine, where tomographic rCBF determinations have been normal.

Sign in / Sign up

Export Citation Format

Share Document