THE RELATIONSHIP OF RENAL BLOOD PRESSURE AND BLOOD FLOW TO THE PRODUCTION OF EXPERIMENTAL HYPERTENSION

1941 ◽  
Vol 134 (3) ◽  
pp. 493-502 ◽  
Author(s):  
Meyer Friedman ◽  
Harold Sugarman ◽  
Arthur Selzer
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Experimental Hypertension ◽  
Relationship Of ◽  
The Relationship

Autoregulation of renal blood flow in the rat: effects of growth and uninephrectomy

1983 ◽  
Vol 244 (5) ◽  
pp. F483-F487 ◽  
Author(s):  
R. L. Chevalier ◽  
D. L. Kaiser
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Young Animal ◽  
Normal Growth ◽  
Sham Operation ◽  
Adult Rats ◽  
Arterial Blood ◽  
Relationship Of ◽  
The Relationship

As a result of normal maturation or after reduction in renal mass, renal blood flow (RBF) progressively increases. However, the effects of renal growth on the relationship of RBF to renal perfusion pressure (RPP) have not been systematically investigated. We examined RBF as a function of RPP in anesthetized young and adult rats that had been subjected to uninephrectomy or sham operation 3-4 wk previously. As a result of normal growth, mean arterial blood pressure increased from 94.1 +/- 2.7 (SE) to 118.9 +/- 4.2 mmHg. The calculated autoregulation factor, in which a value less than 1 indicates the presence of autoregulation, was 0.44 +/- 0.10 over RPP 70-100 mmHg and 1.74 +/- 0.25 over RPP 40-70 mmHg in sham-operated young animals. In adult sham-operated rats, the factor was 0.38 +/- 0.07 over RPP 100-130 mmHg and 1.03 +/- 0.07 over RPP 70-100 mmHg. Uninephrectomy in adults resulted in a 30% rise in RBF over RPP 100-130 mmHg, and there was no change in the autoregulation factor. Uninephrectomy in young rats, however, resulted in a 35% rise in RBF at RPP = 100 mmHg with only a 17% rise at RPP = 70 mmHg, and the autoregulation factor increased to 0.91 +/- 0.10 over this range of RPP. We conclude that the autoregulatory range shifts with increasing blood pressure during normal growth and that autoregulation is "reset" to higher RBF in the uninephrectomized adult rat. Although autoregulation takes place in the young animal, uninephrectomy alters the relationship of RBF to RPP such that autoregulation is impaired.

The relationship of the CO2 reactivity of cerebral vessels to blood pressure and mean resting blood flow

Neurology ◽  
1973 ◽  
Vol 23 (1) ◽  
pp. 21-21 ◽  
Author(s):  
R. H. Ackerman ◽  
E. Zilkha ◽  
J. W.D. Bull ◽  
G. H. Du Boulay ◽  
J. Marshall ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Vessels ◽  
Co2 Reactivity ◽  
Relationship Of ◽  
The Relationship

Renin Tachyphylaxis and Renal Ischemia in the Cat

1956 ◽  
Vol 187 (3) ◽  
pp. 520-524 ◽  
Author(s):  
Douglas R. Drury ◽  
Shawn Schapiro
Keyword(s):  
Blood Pressure ◽  
Pressor Response ◽  
Renal Hypertension ◽  
Renal Ischemia ◽  
Elevated Blood Pressure ◽  
Experimental Hypertension ◽  
Elevated Blood ◽  
Relationship Of ◽  
The Relationship

The production of renin by the completely ischemic cat's kidney was investigated, as well as the relationship of renin to experimental hypertension in the cat. Tachyphylaxis to hog renin abolishes the pressor response following endogenous renin production by the completely ischemic kidney. However, the elevated blood pressure which occurs following partial renal ischemia (renal hypertension) is not reduced after renin tachyphylaxis. It is therefore concluded that the mechanism responsible for the elevation in blood pressure in the two cases is on a qualitatively different basis.

scholarly journals 600 THE RELATIONSHIP OF CHILDHOOD AND ADULT BLOOD PRESSURE–30 YEARS LATER

1985 ◽  
Vol 19 (4) ◽  
pp. 210A-210A
Author(s):  
Ruth Whittemore ◽  
G J Beck ◽  
Lisa McKay
Keyword(s):  
Blood Pressure ◽  
Relationship Of ◽  
The Relationship

Relation of blood flow to VO2, PO2, and PCO2 in dog gastrocnemius muscle

1988 ◽  
Vol 255 (5) ◽  
pp. H1004-H1010 ◽  
Author(s):  
D. E. Mohrman ◽  
R. R. Regal
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Gastrocnemius Muscle ◽  
Muscle Blood Flow ◽  
Carbon Dioxide Tension ◽  
Experimental Conditions ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Relationship Of ◽  
The Relationship

We pump-perfused gastrocnemius-plantaris muscle preparations at constant pressure to study the relationship of muscle blood flow (Q) to muscle oxygen consumption (VO2), venous oxygen tension (PVO2), and venous carbon dioxide tension (PVCO2) during steady-state exercise at different rates. Tests were performed under four experimental conditions produced by altering the perfusate blood-gas status with a membrane lung. The consistency of the relationship of Q to other variables was evaluated by statistical analysis of fitted curves. Not one of the above listed variables had the same relationship with Q in all four of the experimental conditions we tested. However, we did find that a consistent relationship existed among Q, PVO2, and PVCO2 in our data. That relationship is well described by the equation (Q-23).[PVO2 - (0.5.PVCO2) - 3] = 105 (when Q is expressed in ml.100 g-1.min-1 and PVO2 and PVCO2 in mmHg). One interpretation of this result is that both PO2 and PCO2 are important variables in the control of blood flow in skeletal muscle the combined influence of which could account for nearly all of the hyperemia response to steady-state muscle exercise.

Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy

1961 ◽  
Vol 200 (6) ◽  
pp. 1169-1176 ◽  
Author(s):  
William E. Huckabee
Keyword(s):  
Blood Flow ◽  
Coronary Flow ◽  
Cardiac Tissue ◽  
Anaerobic Metabolism ◽  
Constant Ratio ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Relationship Of ◽  
The Relationship

Veno-arterial differences of pyruvate and lactate across the myocardium in chloralose-anesthetized dogs were very variable; in any one animal they changed continually with time despite constant blood flow and arterial blood concentrations. There was a systematic tendency of v-a lactate to vary with v-a pyruvate, as expressed in the calculated "Δ excess lactate," which remained nearly constant (or, if blood flow changed, bore a constant ratio to (a-v)O2). No change in Δ excess lactate from control values occurred in nonhypoxic experiments despite marked changes in v-a differences, arterial blood composition, and coronary flow. Cardiac Δ excess lactate became positive in most animals breathing 10% O2 in N2; output of excess lactate was also observed in all those in which moderate muscular exercise was induced. This anaerobic metabolism, or change in the relationship between pyruvate and lactate exchanges, was interpreted as an indication that O2 delivery response was not adequate to meet cardiac tissue requirements during such mild stresses when judged by the standards of adequacy of the basal state.

Relation of local skin temperature and local sweating to cutaneous blood flow

1963 ◽  
Vol 18 (4) ◽  
pp. 781-785 ◽  
Author(s):  
Leo C. Senay ◽  
Leon D. Prokop ◽  
Leslie Cronau ◽  
Alrick B. Hertzman
Keyword(s):  
Blood Flow ◽  
Skin Temperature ◽  
Sweat Gland ◽  
Cutaneous Blood Flow ◽  
Local Skin ◽  
Cutaneous Vasodilatation ◽  
Local Skin Temperature ◽  
Relationship Of ◽  
The Relationship ◽  
Cutaneous Blood

The relationship of local skin temperature and the onset of sweating to the local cutaneous blood flow was studied in the forearm and calf. The purpose of the investigation was to appraise the possible relation of sweat gland activity to the cutaneous vasodilatation which has been attributed to bradykinin or to intracranial temperatures. The onset of sweating was not marked by any apparently related increases in the rate of cutaneous blood flow. On the contrary, the onset of sweating was followed often by a stabilization or even a decrease in the level of cutaneous blood flow. The relations of the latter to the local skin temperature were complex, particularly in the forearm. There appeared to be additional unidentified influences, possibly vasomotor, operating on the skin vessels during transitional phases in the relation of skin temperature to blood flow. Submitted on October 15, 1962

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