Renin Tachyphylaxis and Renal Ischemia in the Cat

1956 ◽  
Vol 187 (3) ◽  
pp. 520-524 ◽  
Author(s):  
Douglas R. Drury ◽  
Shawn Schapiro
Keyword(s):  
Blood Pressure ◽  
Pressor Response ◽  
Renal Hypertension ◽  
Renal Ischemia ◽  
Elevated Blood Pressure ◽  
Experimental Hypertension ◽  
Elevated Blood ◽  
Relationship Of ◽  
The Relationship

The production of renin by the completely ischemic cat's kidney was investigated, as well as the relationship of renin to experimental hypertension in the cat. Tachyphylaxis to hog renin abolishes the pressor response following endogenous renin production by the completely ischemic kidney. However, the elevated blood pressure which occurs following partial renal ischemia (renal hypertension) is not reduced after renin tachyphylaxis. It is therefore concluded that the mechanism responsible for the elevation in blood pressure in the two cases is on a qualitatively different basis.

scholarly journals STUDIES ON EXPERIMENTAL HYPERTENSION

1940 ◽  
Vol 71 (2) ◽  
pp. 175-185 ◽  
Author(s):  
Harry Goldblatt ◽  
Joseph R. Kahn ◽  
Francis Bayless ◽  
Morris A. Simon
Keyword(s):  
Blood Pressure ◽  
Carotid Sinus ◽  
Renal Ischemia ◽  
The Other ◽  
Mean Blood Pressure ◽  
Elevated Blood Pressure ◽  
Experimental Hypertension ◽  
Elevated Blood ◽  
Significant Difference ◽  
Regulation Of Blood Pressure

Excision of both carotid sinuses, with or without section of cardio-aortic inhibitor fibers, was not followed by a significant change of femoral mean blood pressure from the normal. This procedure did not interfere with the development of hypertension produced by renal ischemia. There was no significant difference between the levels of hypertension due to renal ischemia in animals with both carotid sinuses previously excised and in those with both carotid sinuses intact. In one of three animals with hypertension due to renal ischemia, in which the elevated blood pressure had gradually subsided, there was a slight and only temporary reelevation of pressure after excision of both carotid sinuses. In the other two animals, excision of the carotid sinuses had no effect on the blood pressure. In all three, however, increased constriction of the renal arteries caused significant and persistent reelevation of the blood pressure. The carotid sinus has no demonstrable influence upon hypertension caused by renal ischemia, although in such animals it probably plays the same part in the regulation of blood pressure as it does in normal animals (7).

ROLE OF THE THYROID GLAND IN DEVELOPMENT AND MAINTENANCE OF RENAL HYPERTENSION IN RATS

1960 ◽  
Vol XXXIV (III) ◽  
pp. 411-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Kenneth M. Cook
Keyword(s):  
Blood Pressure ◽  
Rate Increase ◽  
Renal Hypertension ◽  
The Other ◽  
Elevated Blood Pressure ◽  
Unit Weight ◽  
Elevated Blood ◽  
Inhibition Of Growth ◽  
Testicular Size

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.

Renin content and excretory function of the kidney in rats with experimental hypertension

1962 ◽  
Vol 202 (4) ◽  
pp. 795-799 ◽  
Author(s):  
H. Brunner ◽  
P. A. Desaulles ◽  
D. Regoli ◽  
F. Gross
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Renal Hypertension ◽  
Experimental Hypertension ◽  
Elevated Blood ◽  
Hypertensive Rats ◽  
Excretory Function ◽  
Contralateral Kidney ◽  
Ligation Of The Ureter ◽  
Renin Content

To determine relationship between kidney renin content and excretory function, rats with renal hypertension induced by unilateral clamping of the renal artery were given an oral load of 3 ml of 0.9% saline/100 g body wt. Excretion of the saline load was accelerated in rats with renal hypertension as well as in animals with hypertension due to overdosage with cortexone and salt, provided that the loading experiment was made 3–4 weeks after hypertension was established, but not when animals had been hypertensive for 11–14 weeks. Renin concentration was markedly reduced in the unclamped kidney and also in the kidney of the rats overdosed with cortexone and salt. Excreting capacity of the clamped kidney was compared with that of the unclamped kidney, after removal or after functional elimination of the contralateral kidney, by ligation of the ureter, 3, 24, and 48 hr after the operation. In all experiments excretion of saline load by the unclamped kidney was more rapid than by the clamped kidney, but the highest values were reached in the presence of a functional clamped kidney. Only in rats with elevated blood pressure was the load more rapidly excreted than in normal rats, but hypertension alone cannot be the only factor responsible, the excretion not being accelerated in unilaterally nephrectomized hypertensive rats. Although these hint at a connection between the renin concentration and renal function the nature of this relationship remains uncertain.

Distress tolerance moderates the relationship between anger experience and elevated blood pressure

2019 ◽  
Vol 50 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Maria Chidi C Onyedibe ◽  
Peace N Ibeagha ◽  
Ike E Onyishi
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Distress Tolerance ◽  
Diastolic Pressure ◽  
Short Form ◽  
University Teaching ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Anger Experience ◽  
The Relationship

Previous studies have linked anger to elevated blood pressure. However, the nature of the association between anger and elevated blood pressure is unclear. This study is aimed at investigating the moderating effect of distress tolerance on the relationship between anger experience and elevated blood pressure. A total of 310 patients drawn from a university teaching hospital in southeast Nigeria participated in this study. They comprised 156 men and 154 women who were aged between 20 and 80 years (mean age = 50.45). Participants responded to the measures of distress tolerance and Novaco Anger Inventory—Short Form. The blood pressures of the participants were obtained with sphygmomanometer and stethoscope. The results of the hierarchical multiple regression analysis indicated that anger experience significantly predicted both systolic and diastolic blood pressure. The results also showed that distress tolerance was a significant predictor of systolic and diastolic blood pressure. Distress tolerance moderated the relationship between anger experience and systolic and diastolic blood pressure. The relationships between anger and systolic and diastolic pressure were stronger for patients with low distress tolerance compared to patients with high distress tolerance. It is recommended that psychological interventions aimed at increasing people’s level of distress tolerance are emphasized in the management of elevated blood pressure.

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