Membrane impedance changes during synaptic transmission in cat spinal motoneurons.

1967 ◽  
Vol 30 (5) ◽  
pp. 1072-1096 ◽  
Author(s):  
T G Smith ◽  
R B Wuerker ◽  
K Frank
Keyword(s):  
Synaptic Transmission ◽  
Spinal Motoneurons ◽  
Membrane Impedance

Effects of 4-aminopyridine on the action potential and the after-hyper polarization of cat spinal motoneurons

1986 ◽  
Vol 64 (11) ◽  
pp. 1402-1406 ◽  
Author(s):  
Liang Zhang ◽  
Kresimir Krnjevic
Keyword(s):  
Action Potential ◽  
Synaptic Transmission ◽  
Time Course ◽  
Ionic Channels ◽  
Excitatory Postsynaptic Potentials ◽  
Spinal Motoneurons ◽  
K Channels ◽  
Postsynaptic Potentials ◽  
Pentobarbital Anaesthesia

In cats under pentobarbital anaesthesia, intramotoneuronal administrations of 4-aminopyridine significantly prolong the falling phase of the antidromic action potential but have much less effect on the orthodromic action potential. 4-aminopyridine probably blocks the fast K channels involved in the repolarization of the membrane and indirectly activates ionic channels through enhancement of synaptic transmission, also suggested by the potentiation of excitatory postsynaptic potentials. In many cells, 4-aminopyridine depresses the amplitude and prolongs the time course of the after-hyperpolarization; therefore 4-aminopyridine may also partly block Ca2+-activated K+ channels.

Synaptic Transmission. 2nd ed.

1970 ◽  
Vol 15 (6) ◽  
pp. 431-431
Author(s):  
GARTH J. THOMAS
Keyword(s):  
Synaptic Transmission
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