Atrial Natriuretic Peptide as a Regulator of Transvascular Fluid Balance

Physiology ◽  
1996 ◽  
Vol 11 (3) ◽  
pp. 138-143 ◽  
Author(s):  
EM Renkin ◽  
VL Tucker
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Fluid Balance ◽  
Interstitial Fluid ◽  
Fluid Volume ◽  
Interstitial Fluid Volume ◽  
Atrial Natriuretic

Unlike other natriuretics, which act via the kidneys to reduce interstitial fluid volume with little change in plasma volume, atrial natriuretic peptide has important extrarenal actions that enable it to reduce plasma volume preferentially.

Inhibition of contraction of isolated lymphatic ducts by atrial natriuretic peptide

1991 ◽  
Vol 260 (3) ◽  
pp. R610-R614 ◽  
Author(s):  
W. D. Anderson ◽  
T. J. Kulik ◽  
J. E. Mayer
Keyword(s):  
Smooth Muscle ◽  
Atrial Natriuretic Peptide ◽  
Blood Vessels ◽  
Natriuretic Peptide ◽  
Dose Response ◽  
Fluid Balance ◽  
Interstitial Fluid ◽  
Force Of Contraction ◽  
Response Curves ◽  
Atrial Natriuretic

Atrial natriuretic peptide (ANP) potently relaxes blood vessels but its effect on lymphatic motility is unreported. We studied the effect of ANP, and the smooth muscle relaxing agent nitroprusside (NP), on isolated ovine mesenteric lymphatic ducts. Duct segments were mounted on a myograph, and noncumulative dose-response curves were obtained for the effect of ANP and NP on the rate and force of spontaneous (and norepinephrine-induced) duct contraction. Both ANP (threshold approximately 1 nM) and NP (threshold approximately 10 nM) in a dose-related fashion reduced the frequency and force of contraction of both spontaneously contracting and norepinephrine-stimulated duct segments. ANP may therefore affect interstitial fluid balance through its effect on lymphatic motility.

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1988 ◽  
Vol 13 ◽  
pp. S62-S68
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

scholarly journals Edemagenic gain and interstitial fluid volume regulation

2008 ◽  
Vol 294 (2) ◽  
pp. R651-R659 ◽  
Author(s):  
R. M. Dongaonkar ◽  
C. M. Quick ◽  
R. H. Stewart ◽  
R. E. Drake ◽  
C. S. Cox ◽  
...  
Keyword(s):  
Fluid Balance ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Venous Hypertension ◽  
Fluid Volume ◽  
Balance Equations ◽  
Factors Affecting ◽  
Venous Circulation ◽  
Interstitial Fluid Volume ◽  
Simplifying Assumptions

Under physiological conditions, interstitial fluid volume is tightly regulated by balancing microvascular filtration and lymphatic return to the central venous circulation. Even though microvascular filtration and lymphatic return are governed by conservation of mass, their interaction can result in exceedingly complex behavior. Without making simplifying assumptions, investigators must solve the fluid balance equations numerically, which limits the generality of the results. We thus made critical simplifying assumptions to develop a simple solution to the standard fluid balance equations that is expressed as an algebraic formula. Using a classical approach to describe systems with negative feedback, we formulated our solution as a “gain” relating the change in interstitial fluid volume to a change in effective microvascular driving pressure. The resulting “edemagenic gain” is a function of microvascular filtration coefficient ( K f), effective lymphatic resistance ( R L), and interstitial compliance ( C). This formulation suggests two types of gain: “multivariate” dependent on C, R L, and K f, and “compliance-dominated” approximately equal to C. The latter forms a basis of a novel method to estimate C without measuring interstitial fluid pressure. Data from ovine experiments illustrate how edemagenic gain is altered with pulmonary edema induced by venous hypertension, histamine, and endotoxin. Reformulation of the classical equations governing fluid balance in terms of edemagenic gain thus yields new insight into the factors affecting an organ's susceptibility to edema.

Distribution volumes of [131I]albumin, [14C]sucrose, and 36Cl in sheep lung

1975 ◽  
Vol 39 (5) ◽  
pp. 773-779 ◽  
Author(s):  
S. L. Selinger ◽  
R. D. Bland ◽  
R. H. Demling ◽  
N. C. Staub
Keyword(s):  
Plasma Volume ◽  
Interstitial Fluid ◽  
Fluid Volume ◽  
The Body ◽  
Constant Infusion ◽  
Red Cell ◽  
Lung Water ◽  
Lung Weight ◽  
Interstitial Fluid Volume ◽  
Volumes Of Distribution

We measured the steady-state volumes of distribution for radioactive chloride, sucrose, and albumin in the lung of six anesthetized, spen-thorax sheep. We allowed 2 days for [131I]albumin to equilibrate throughout the body, 2 h for the 36Cl, and a 40-min constant infusion for [14C]sucrose before killing the animal. Five minutes before death, we gave [125I]albumin to tag lung plasma volume. We killed the animals by clamping both lung hila; we then removed the lungs and homogenized them. We measured residual red cell and plasma volume, total extravascular lung water, and the extravascular content of the three tracers. The distribution volumes expressed as fractions of blood-free lung weight were: 36Cl equals 0.44, sucrose equals 0.28, and albumin equals 0.07. If the sucrose distribution volume is taken as the best estimate of the lung's extravascular extracellular space, then chloride clearly overestimates the interstitial fluid volume, being either bound or partially intracellular. On the other hand, albumin clearly underestimates the interstitial fluid volume.

Atrial Natriuretic Peptide and Response to Changing Plasma Volume in Diabetic Nephropathy

Diabetes ◽  
1991 ◽  
Vol 40 (7) ◽  
pp. 893-901 ◽  
Author(s):  
J. S. Lieberman ◽  
L. Parra ◽  
L. Newton ◽  
J. D. Scandling ◽  
N. Loon ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Atrial Natriuretic

scholarly journals Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats

1998 ◽  
Vol 512 (1) ◽  
pp. 227-234 ◽  
Author(s):  
Xiao-Wu Qu ◽  
Ranna A. Rozenfeld ◽  
Wei Huang ◽  
Susan E. Crawford ◽  
F. Gonzalez-Crussi ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Volume Regulation ◽  
Platelet Activating Factor ◽  
Atrial Natriuretic
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