Potential Capsule Switching from Serogroup Y to B: The Characterization of Three suchNeisseria meningitidisIsolates Causing Invasive Meningococcal Disease in Canada

Three group BNeisseria meningitidisisolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.

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Meningococcal Group B Vaccine For The Prevention Of Invasive Meningococcal Disease Caused By Neisseria meningitidis Serogroup B

Infection and Drug Resistance ◽

10.2147/idr.s159952 ◽

2019 ◽

Vol Volume 12 ◽

pp. 3169-3188 ◽

Cited By ~ 2

Author(s):

Irene Rivero-Calle ◽

Peter Francis Raguindin ◽

Jose Gómez-Rial ◽

Carmen Rodriguez-Tenreiro ◽

Federico Martinón-Torres

Keyword(s):

Neisseria Meningitidis ◽

Meningococcal Disease ◽

Invasive Meningococcal Disease ◽

Meningococcal Group ◽

Group B

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Genome Sequence of a Neisseria meningitidis Capsule Null Locus Strain from the Clonal Complex of Sequence Type 198

Journal of Bacteriology ◽

10.1128/jb.01099-12 ◽

2012 ◽

Vol 194 (18) ◽

pp. 5144-5145 ◽

Cited By ~ 7

Author(s):

Sabine Schork ◽

Andreas Schlüter ◽

Jochen Blom ◽

Susanne Schneiker-Bekel ◽

Alfred Pühler ◽

...

Keyword(s):

Neisseria Meningitidis ◽

Genome Sequence ◽

Meningococcal Disease ◽

Clonal Complex ◽

Sequence Type ◽

Invasive Meningococcal Disease ◽

Content Type ◽

Polysaccharide Capsules

ABSTRACTNeisseria meningitidisis a commensal and accidental pathogen exclusively of humans. Although the production of polysaccharide capsules is considered to be essential for meningococcal virulence, there have been reports of constitutively unencapsulated strains causing invasive meningococcal disease (IMD). Here we report the genome sequence of a capsule null locus (cnl) strain of sequence type 198 (ST-198), which is found in half of the reported cases of IMD caused bycnlmeningococcal strains.

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Invasive meningococcal disease due to ciprofloxacin-resistant Neisseria meningitidis sequence type 4821: The first case in Japan

Journal of Infection and Chemotherapy ◽

10.1016/j.jiac.2017.11.001 ◽

2018 ◽

Vol 24 (4) ◽

pp. 305-308 ◽

Cited By ~ 6

Author(s):

Yu Kawasaki ◽

Kousaku Matsubara ◽

Hideyuki Takahashi ◽

Masatomo Morita ◽

Makoto Ohnishi ◽

...

Keyword(s):

Neisseria Meningitidis ◽

Meningococcal Disease ◽

Sequence Type ◽

Invasive Meningococcal Disease ◽

First Case

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Molecular characterization of Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease in Colombia from 2013 to 2016

PLoS ONE ◽

10.1371/journal.pone.0234475 ◽

2020 ◽

Vol 15 (7) ◽

pp. e0234475

Author(s):

Jaime Moreno ◽

Zonia Alarcon ◽

Eliana Parra ◽

Carolina Duarte ◽

Olga Sanabria ◽

...

Keyword(s):

Neisseria Meningitidis ◽

Molecular Characterization ◽

Meningococcal Disease ◽

Invasive Meningococcal Disease

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Effectiveness of meningococcal vaccines at reducing invasive meningococcal disease and pharyngeal Neisseria meningitidis carriage: A systematic review and meta-analysis

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1733 ◽

2020 ◽

Author(s):

Mark McMillan ◽

Abira Chandrakumar ◽

Hua Lin Rachael Wang ◽

Michelle Clarke ◽

Thomas R Sullivan ◽

...

Keyword(s):

Neisseria Meningitidis ◽

Meningococcal Disease ◽

Incidence Rate Ratio ◽

Meta Analysis ◽

Membrane Vesicle ◽

Invasive Meningococcal Disease ◽

Meningococcal Vaccines ◽

Unpublished Studies ◽

Group B ◽

4Cmenb Vaccine

Abstract Background Invasive meningococcal disease (IMD), caused by Neisseria meningitidis, leads to significant morbidity and mortality worldwide. This review aimed to establish the effectiveness of meningococcal vaccines at preventing IMD and N. meningitidis pharyngeal carriage. Methods A search within PubMed, Embase, Scopus, and unpublished studies up to 1st February 2020 was conducted. Results After removal of duplicates, 8565 were screened and 28 studies included. Protection was provided by meningococcal C vaccines for group C IMD (odds ratio (OR) 0·13 [95% CI, 0·07-0·23]), outer membrane vesicle (OMV) vaccines against group B IMD (OR 0·35 [0·25-0·48]), and meningococcal ACWY (MenACWY) vaccines against group ACWY IMD (OR 0·31 [0·20-0·49]). A single time series analysis found a reduction following an infant 4CMenB program (incidence rate ratio, 0·25 [0·19-0·36]). Multivalent MenACWY vaccines did not reduce carriage (relative risk [RR] 0·88 [0·66-1·18]), unlike monovalent A (RR 0·73 [0·61-0·85]), and C vaccines (RR 0·50 [0·26-0·97]). 4CMenB vaccine had no effect on group B carriage (RR 1·12 [0·90-1·40]). There was also no reduction in group B carriage following MenB-FHbp vaccination (RR 0.98 [0.53-1.79]). Conclusions Meningococcal conjugate C, ACWY, and OMV vaccines are effective at reducing IMD. A small number of studies demonstrate that monovalent C and A conjugate vaccines reduce pharyngeal N. meningitidis carriage. There is no evidence of carriage reduction for multivalent MenACWY, OMV, or recombinant meningococcal B vaccines, which has implications for immunisation strategies. Registration PROSPERO CRD42018082085

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