scholarly journals The Role of Iron in the Pathophysiology and Treatment of Chronic Hepatitis C

2009 ◽  
Vol 23 (12) ◽  
pp. 822-828 ◽  
Author(s):  
Leslie Price ◽  
Kris V Kowdley
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Disease Progression ◽  
Chronic Hepatitis C ◽  
Gene Mutations ◽  
Hepatic Iron ◽  
Hepatitis C Infection ◽  
Iron Depletion ◽  
Hepatic Iron Overload ◽  
Hemochromatosis Gene

Increased hepatic iron content may be observed in patients with chronic hepatitis C infection, and may contribute to disease severity. The presence of hemochromatosis gene mutations is associated with increased hepatic iron accumulation and may lead to accelerated disease progression. Hepatic iron depletion has been postulated to decrease the risk of hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C. It is possible that iron depletion stabilizes or improves liver histology and slows disease progression in these individuals. The present article reviews the prevalence and risk factors for hepatic iron overload in chronic hepatitis C, with emphasis on the available data regarding the efficacy of iron depletion in the treatment of this common liver disease.

Hemochromatosis gene mutations in chronic hepatitis C patients with and without liver siderosis

2000 ◽  
Vol 60 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Francesco Negro ◽  
Kaveh Samii ◽  
Laura Rubbia-Brandt ◽  
Rafael Quadri ◽  
Pierre-Jean Male ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Mutations ◽  
Hemochromatosis Gene ◽  
Chronic Hepatitis C Patients

Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C

2004 ◽  
Vol 24 (4) ◽  
pp. 285-294 ◽  
Author(s):  
Andreas Geier ◽  
Michael Reugels ◽  
Ralf Weiskirchen ◽  
Hermann E. Wasmuth ◽  
Christoph G. Dietrich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Mutations ◽  
Hemochromatosis Gene

scholarly journals Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Hironori Mitsuyoshi ◽  
Kohichiroh Yasui ◽  
Kanji Yamaguchi ◽  
Masahito Minami ◽  
Takeshi Okanoue ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Iron Overload ◽  
Chronic Hepatitis C ◽  
Iron Deposition ◽  
Hepatic Iron ◽  
Deposition Pattern ◽  
Hepatic Iron Overload ◽  
Hepcidin Mrna

Aim. Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC.Methods. Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients. The levels of serum soluble TNF-αreceptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns.Results. Serum transaminase levels and hepatic scores of stage, grade, and steatosis were higher in patients with REC iron staining than in those without. REC iron scores were independently associated with advanced stage. Serum sTNFR2 levels were significantly higher in patients with REC iron than in those without. REC iron scores were independently correlated with sTNFR2 levels. Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin. The efficacy of phlebotomy was greater in patients with REC iron than in those without REC iron.Conclusions. The present results show the importance of REC iron for the development of CHepC and the therapeutic effect of phlebotomy in CHepC.

The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C

1999 ◽  
Vol 116 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Lili Kazemi-Shirazi ◽  
Christian Datz ◽  
Theresia Maier-Dobersberger ◽  
Klaus Kaserer ◽  
Franz Hackl ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Iron Status ◽  
Gene Mutations ◽  
Hemochromatosis Gene
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