scholarly journals A Comparison of the Proteomic Expression in Pooled Saliva Specimens from Individuals Diagnosed with Ductal Carcinoma of the Breast with and without Lymph Node Involvement

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Charles F. Streckfus ◽  
Karen A. Storthz ◽  
Lenora Bigler ◽  
William P. Dubinsky
Keyword(s):  
Lymph Node ◽  
Ductal Carcinoma ◽  
Lymph Node Involvement ◽  
Salivary Protein ◽  
Differentially Expressed Proteins ◽  
Carcinoma Of The Breast ◽  
Reverse Phase ◽  
Itraq Reagent ◽  
Node Involvement ◽  
Pooled Samples

Purpose. The objective was to compare the salivary protein profiles of saliva specimens from individuals diagnosed with invasive ductal carcinoma of the breast (IDC) with and without lymph node involvement.Methods. Three pooled saliva specimens from women were analyzed. One pooled specimen was from healthy women; another was from women diagnosed with Stage IIa IDC and a specimen from women diagnosed with Stage IIb. The pooled samples were trypsinized and the peptide digests labeled with the appropriate iTRAQ reagent. Labeled peptides from each of the digests were combined and analyzed by reverse phase capillary chromatography on an LC-MS/MS mass spectrometer.Results. The results yielded approximately 174 differentially expressed proteins in the saliva specimens. There were 55 proteins that were common to both cancer stages in comparison to each other and healthy controls while there were 20 proteins unique to Stage IIa and 28 proteins that were unique to Stage IIb.

HER2 Protein Overexpression in Infiltrating Ductal Carcinoma of the Breast Associated with Lymph Node Involvement

2009 ◽  
Vol 6 (3) ◽  
pp. 445-448
Author(s):  
Adrienne Pratti Lucarelli ◽  
Maria Marta Martins ◽  
Vilmar Marques Oliveira ◽  
Maria Antonieta Longo Galv ◽  
Joao Marcelo Guedes ◽  
...  
Keyword(s):  
Lymph Node ◽  
Ductal Carcinoma ◽  
Lymph Node Involvement ◽  
Protein Overexpression ◽  
Carcinoma Of The Breast ◽  
Her2 Protein ◽  
Infiltrating Ductal Carcinoma ◽  
Node Involvement

scholarly journals Salivary Protein Profiles among HER2/neu-Receptor-Positive and -Negative Breast Cancer Patients: Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Charles F. Streckfus ◽  
Daniel Arreola ◽  
Cynthia Edwards ◽  
Lenora Bigler
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Salivary Protein ◽  
Differentially Expressed Proteins ◽  
Protein Profiles ◽  
Breast Cancer Patients ◽  
Itraq Reagent ◽  
Pooled Samples ◽  
Positive Breast Cancer

Purpose. The objective of this study was to compare the salivary protein profiles from individuals diagnosed with breast cancer that were either HER2/neu receptor positive or negative.Methods. Two pooled saliva specimens underwent proteomic analysis. One pooled specimen was from women diagnosed with stage IIa HER2/neu-receptor-positive breast cancer patients (n=10) and the other was from women diagnosed with stage IIa HER2/neu-receptor-negative cancer patients (n=10). The pooled samples were trypsinized and the peptides labeled with iTRAQ reagent. Specimens were analyzed using an LC-MS/MS mass spectrometer.Results. The results yielded approximately 71 differentially expressed proteins in the saliva specimens. There were 34 upregulated proteins and 37 downregulated proteins.

scholarly journals Mucinous Carcinoma of The Breast: Report of Two Cases

2019 ◽  
Vol 17 (1) ◽  
pp. 45-49
Author(s):  
Atiar Rahman ◽  
M Rahman ◽  
M Momotaz ◽  
R Alam ◽  
M Hossain ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Bone Metastasis ◽  
Mucinous Carcinoma ◽  
Lymph Node Involvement ◽  
Carcinoma Of The Breast ◽  
Early Presentation ◽  
Epithelial Origin ◽  
Node Involvement ◽  
Malignant Lesions

Mucinous carcinoma of the breast is one of 16 rare varieties of malignant lesions of epithelial origin Inbreast. They account for 1-6% of all breast cancer. Variations Inpresentation, cllnlcal course and prognosis has been observed in these patients. In this communication we report two cases of pure mucinous carcinoma of the breast .Both the cases were unusual, first one of them having early presentation with pulmonary and bone metastasis less commonly seen In this type of breast carcinoma and the second case had lymph node involvement that is seen in less than one fifth of the cases of mucinous carcinoma of breast. A brief review about mucinous carcinoma is supplemented with the report. Journal of Surgical Sciences (2013) Vol. 17 (1) : 45-49

scholarly journals Synchronic presentation of breast ductal carcinoma and follicular lymphoma: a diagnostic challenge

Mastology ◽  
2020 ◽  
Vol 30 ◽  
Author(s):  
Priscila Nunes Silva Morosini ◽  
Murilo do Valle Sabóia ◽  
Tereza Cavalcanti ◽  
Ágata Rothert ◽  
Marcela Cavalcant
Keyword(s):  
Lymph Node ◽  
Axillary Lymph Node ◽  
World Literature ◽  
Ductal Carcinoma ◽  
Breast Disease ◽  
Lymph Node Involvement ◽  
Axillary Lymph ◽  
Diagnostic Challenge ◽  
Node Involvement ◽  
Axillary Lymph Node Involvement

Synchronic tumors are rare events, even more clinically presenting as a rational metastatic sequence: breast cancer followed by axillary lymph node involvement. In the present case, after mastectomy associated with axillary emptying in a postmenopausal patient, we identified in the pathological report the presence of breast disease: invasive ductal carcinoma. However, differently from what was expected by the clinical examination, axillary lymph node involvement was not due to a disease of mammary origin, but to non-Hodgkin’s lymphoma — a new primary. In the world literature, there are few similar reports, and it is still necessary to accumulate similar cases to be able to hypothesize a single causality between these two tumor subtypes or cause-consequence relationship between the two entities.

Sentinel Lymph Node Involvement in Ductal Carcinoma In-Situ of the Breast: Two Different Causes

2012 ◽  
Vol 12 (5) ◽  
pp. 378-381
Author(s):  
Olivier Brouckaert ◽  
Anneleen Reynders ◽  
Kathleen Vanderstappen ◽  
Ann Smeets ◽  
Ann Hoeben ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Lymph Node Involvement ◽  
Node Involvement
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